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• Glioma Papers •
Histogram analysis for quantitative dynamic contrast enhanced MRI in grading of glioma
NAN Hai-yan  YAN Lin-feng  ZHANG Xin  YANG Yang  HAN Yu  WANG Wen  CUI Guang-bin 

DOI:10.12015/issn.1674-8034.2018.10.003.


[Abstract] Objective: This study aimed to quantitatively evaluate the value of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in grading of glioma using histogram analysis.Materials and Methods: One hundred and twenty glioma patients were included with 28 low grade gliomas (LGG, grade Ⅰ and grade Ⅱ) and 92 high grade gliomas (HGG, grade Ⅲ and grade Ⅳ). Permeability parameters, including Ktrans, Kep, Ve, Vp, and perfusion parameters, including IAUGC, CBF and MTT, were derived from DCE-MRI by applying the modified two-compartment extended toft model. Unpaired t test and Mann-Whitney U test were used to compare the difference between DCE-MRI histogram parameters of different grade gliomas. The diagnostic efficiency, sensitivity, specificity and the corresponding diagnostic threshold value of different parameters were then compared by ROC.Results: There were significant differences of Ktrans, Kep, Ve, IAUGC and MTT between LGG and HGG (P<0.05). The results of ROC showed that IAUGC and Ve had the best diagnostic performance (P<0.05). The diagnostic efficiency of the 75th percentile of Ktrans had the most significant increase compare with the mean value. The 95th percentile of IAUGC had the best performance.Conclusions: Histogram analysis for DCE-MRI provides valuable information for glioma grading.
[Keywords] Histogram；Dynamic contrast-enhanced；Glioma；Magnetic resonance imaging；Neoplasm grading

NAN Hai-yan Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038, China

YAN Lin-feng Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038, China

ZHANG Xin Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038, China

YANG Yang Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038, China

HAN Yu Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038, China

WANG Wen Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038, China

CUI Guang-bin* Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038, China

*Correspondence to: Cui GB, E-mail: cgbtd@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Social Development and Scientific Research Projects of Shaanxi Province No. 2014JZ2-007 Science and Innovation Development Fund of Tangdu Hospital of Air Force Military Medical University (the Fourth Military Medical University) No. 2016LCYJ001
Received  2018-03-18
DOI: 10.12015/issn.1674-8034.2018.10.003
DOI:10.12015/issn.1674-8034.2018.10.003.

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