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• Glioma Papers •
Prediction of WHO grade Ⅱ glioma gene typing using diffusion kurtosis imaging
WU Wen-jie  ZHANG Hui  WANG Xiao-chun  TAN Yan  QIN JIANG-bo  YANG Guo-qiang 

DOI:10.12015/issn.1674-8034.2018.10.005.


[Abstract] Objective: Using the magnetic resonance imaging (MRI) diffusion kurtosis imaging (DKI) to predict the isocitrate dehydrogenase (IDH) gene state of WHO grade Ⅱ brain gliomas.Materials and Methods: Clinical and imaging data of twenty-five cases patients with WHO grade Ⅱ gliomas were collected and proved by pathology. Patients underwent routine MRI and DKI scanning before surgery, measuring tumoral solid portion, peritumoral edema, and normal appearing white matter (NAWM) DKI parameter value, including fractional anisotropy (FA), mean diffusivity (MD), mean kurtosis (MK), axial kurtosis (Ka), radial kurtosis (Kr). The DKI parameters correction was made (tumor or edema parameters values divided by NAWM value) to obtain the rFA (ratio of FA), rMD (ratio of MD), rMK (ratio of MK), rKa (ratio of Ka), rKr (ratio of Kr) value. Postoperative specimens were made of wax blocks and analyzed by sanger gene sequencing. Twenty-five patients were divided into IDH-mutant (16 cases) and IDH-wild type (9 cases). DKI parameters values between the two groups were comparaed by independent sample t tests. The ROC curve was used to analyze the diagnostic value of each parameter value.Results: After the correction, the rFA and rMK value of the wild-type tumor in IDH were higher than IDH mutation, while the rMD value was lower than IDH mutated type, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the parameters of DKI in the two groups of patients after correction. The area under the ROC curve of the rMK was 75.7%, when the rMK value was 0.515, the sensitivity was 77.8%, and the specificity was 68.7%. The area under the ROC curve of rFA was 72.9%, when the rFA was 0.527, the sensitivity was 66.7%, the specificity was 93.7%. The area under the ROC curve of rMD was 75.7%, when the rMD was 1.261, the sensitivity was 87.5%, the specificity was 66.7%.Conclusions: The correction value of rMK, rFA, and rMD with WHO Ⅱ glioma is helpful to determine the state of IDH gene, and the sensitivity and specificity of the rMK and rMD value were higher.
[Keywords] Gliomas；IDH mutation；Diffusion kurtosis imaging；Genotyping；Magnetic resonance imaging

WU Wen-jie Department of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China

ZHANG Hui* Department of Radiology, the First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

WANG Xiao-chun Department of Radiology, the First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

TAN Yan Department of Radiology, the First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

QIN JIANG-bo Department of Radiology, the First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

YANG Guo-qiang Department of Radiology, the First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China

*Correspondence to: Zhang H, E-mail: zhanghui_mr@163.com

Conflicts of interest   None.

Received  2017-12-30
DOI: 10.12015/issn.1674-8034.2018.10.005
DOI:10.12015/issn.1674-8034.2018.10.005.

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