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• Clinical Article •
Multi-modality MRI study of relationship between carotid atherosclerotic stenosis and cerebral hemodynamics
MA Yu-rong  HAN Na  ZHANG Jing 

DOI:10.12015/issn.1674-8034.2018.10.006.


[Abstract] Objective: Multi-modality MRI technique was used to investigate changes in cerebral hemodynamics with the aggravation of carotid atherosclerosis.Materials and Methods: 39 patients with unilateral carotid artery stenosis were included in the experimental analysis. High-resolution magnetic resonance imaging (HR-MRI) was used to determine the degree of stenosis, while dynamic susceptibility contrast perfusion imaging (DSC-PWI) was performed to evaluate the hemodynamic changes in brain tissue. According to the degree of stenosis, patients were divided into four groups. The perfusion parameters were measured in all patients, including the temporal parietal and frontal lobe. It is analyzed whether there is statistical significance in each group of differences. Evaluated the correlation between stenosis and perfusion values. At the same time, the relative perfusion values of the temporal parietal lobe and the frontal lobe of each group were compared and analyzed.Results: In 39 cases, nine cases showed abnormal frontal perfusion, and 19 cases abnormal perfusion of the temporal parietal lobe, while they were mostly present in the severe and occlusion group. Cerebral hemodynamic abnormalities and changes in perfusion parameters were more likely to occur in the temporal parietal lobe than in the frontal lobe. (P<0.05). Taking the temporal parietal lobe as an example, the degree of carotid artery stenosis is positively correlated with relative mean through time (rMTT), relative time-to-peak (rTTP), relative cerebral blood volume (rCBV) (P<0.01).Conclusions: Severe carotid stenosis or occlusion may result in insufficient blood supply to the distal vessels, reduced perfusion of frontal and temporal parietal lobe.
[Keywords] Magnetic resonance imaging；Carotid stenosis；Degree of stenosis；Hemodynamics；Perfusion-weighted imaging

MA Yu-rong Department of Nuclear Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730000, China

HAN Na Department of Nuclear Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730000, China

ZHANG Jing* Department of Nuclear Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730000, China

*Correspondence to: Zhang J, E-mail: lztong2001@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of PhD Research Foundation of Second Hospital Affiliated to Lanzhou University No. ynbskyjj2015-1-30
Received  2018-04-10
DOI: 10.12015/issn.1674-8034.2018.10.006
DOI:10.12015/issn.1674-8034.2018.10.006.

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