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Application of abbreviated protocol of magnetic resonance imaging in breast cancer high-risk people
MENG You  QU Rui  ZHANG Fan  LIU Chen-lu  SHEN Yu-ying  CAI Qing  CHEN Shuang-qing 

DOI:10.12015/issn.1674-8034.2018.10.009.


[Abstract] Objective: To evaluate the validity of two abbreviated protocol (AP) of MRI in comparison with a full diagnostic protocol (FDP) of MRI in the breast cancer high-risk people.Materials and Methods: Seventy-eight female participants with high-risk of breast cancer were recruited for the study, who were underwent MRI and surgical treatment. Two AP [AP-1: consisting of the first post-contrast subtracted (FAST) and maximum-intensity projection [MIP] images; AP-2: AP-1 combined with diffusion weight imaging (DWI)] and FDP images were analyzed separately, and the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of breast cancer detection were calculated.Results: Histological examination revealed 32 malignant lesions and 46 benign lesions. The average interpretation time of the AP-1 and AP-2 were (78±25) s and (91±29) s, while the average interpretation time of the FDP was (205±54) s (F=12.355, P<0.05). The sensitivity of the AP-1, AP-2, and FDP were respectively 93.8%, 100%, and 100%, and the specificity of the three MR protocols were respectively 76.1%, 91.3%, and 93.5%. In addition, the PPV of the AP-1, AP-2, and FDP were respectively 73.2%, 88.9% and 91.4%, and the PPV of the three MR protocols were respectively 94.6%, 100% and 100%. There was no significant difference among three MR protocols in sensitivity of breast cancer (F=2.142, P>0.05). However, the specificity of AP-1 was significantly lower than that of AP-2 (P<0.05) and FDP (P<0.05), while there was no difference between AP-2 and FDP (P>0.05).Conclusions: The AP may be efficient in the breast cancer screening with high-risk, and FAST+MIP images combined with DWI of MRI are helpful to improve specificity of breast cancer detection.
[Keywords] Breast neoplasms；Magnetic resonance imaging；First post-contrast subtracted；Maximum-intensity projection；Diffusion weight imaging

MENG You Department of Breast Surgery, Suzhou Hospital, Nanjing Medical University, Suzhou 215001, China

QU Rui Department of Breast Surgery, Suzhou Hospital, Nanjing Medical University, Suzhou 215001, China

ZHANG Fan Department of Radiology, Suzhou Hospital, Nanjing Medical University, Suzhou 215001, China

LIU Chen-lu Department of Radiology, Suzhou Hospital, Nanjing Medical University, Suzhou 215001, China

SHEN Yu-ying Department of Radiology, Suzhou Hospital, Nanjing Medical University, Suzhou 215001, China

CAI Qing Department of Radiology, Suzhou Hospital, Nanjing Medical University, Suzhou 215001, China

CHEN Shuang-qing* Department of Radiology, Suzhou Hospital, Nanjing Medical University, Suzhou 215001, China

*Correspondence to: Chen SQ, E-mail: sznaonao@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Clinical Tumor Medicine Center Foundation of Suzhou City No. SZZX201506 Science and Education Xingwei Project of Suzhou City No. KJXW2016030
Received  2018-04-30
DOI: 10.12015/issn.1674-8034.2018.10.009
DOI:10.12015/issn.1674-8034.2018.10.009.

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