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Analysis of MRI signal characteristics of neonatal severe hyperbilirubinemia
MENG Xiao-li  ZHANG Lei  WANG Xiao-hu  ZHAO Ke-ke  SHU Jun  REN Zhuan-qin 

DOI:10.12015/issn.1674-8034.2018.10.010.


[Abstract] Objective: To investigate the MRI features of neonatal severe hyperbilirubinemia and provide objective imaging evidence for clinic.Materials and Methods: 80 cases of hyperbilirubinemia from January 2015 to July 2017 in Baoji Municipal Central Hospital, those were divided into two groups, including 35 cases of high bilirubin group, 20 cases of bilirubin encephalopathy group and correlated with cranial MRI examination. Another option of 30 cases of physiologic jaundice neonatus, who received MR examination. The difference of T1WI signal intensity in the globus pallidus (GP), subthalamic nuclei (STN), thalamus (T) were observed and measured. To analyse the relationship between serum total bilirubin level and signal intensit.Results: The ratio between the globus pallidus and the thalamus (GP/T) and the ratio between subthalamic nuclei and the thalamus (STN/T) were significantly different in T1WI (F=15.854, P=0.000; F=14.057, P=0.000), while T2WI was not statistically significant (F=2.042, P=0.137; F=0.110, P=0.896). Analyze the receiver operating characteristic (ROC) curve of GP/T ratio and STN/T ratio in bilirubin encephalopathy group, area under curve was 0.824, 0.814, the best threshold was 1.56, 1.63, respectively. MRI follow-up of 10 children with bilirubin encephalopathy showed 4 cases with high signal of T2WI in the globus pallidus.Conclusions: When the magnetic resonance T1WI GP/T, SNT/T exceeds 1.56, 1.63 in neonatal severe hyperbilirubinemia, the occurrence of bilirubin encephalopathy should be highly vigilant; While the same region changes to T2WI high signal at chronic stage, the prognosis is poor.
[Keywords] Hyperbilirubinemia, neonatal；Brain diseases；Globus pallidus；Signal intensity；Magnetic resonance imaging

MENG Xiao-li Department of Radiology, Baoji Municipal Central Hospital, Baoji 721008, China; College of Medical Science Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, China

ZHANG Lei Department of Radiology, Baoji Municipal Central Hospital, Baoji 721008, China

WANG Xiao-hu Department of Radiology, Baoji Municipal Central Hospital, Baoji 721008, China

ZHAO Ke-ke College of Medical Science Technology, Shaanxi University of Chinese Medicine, Xianyang 712046, China

SHU Jun Department of Radiology, Xijing Hospital Affiliated to the Air force Medical University, Xi’an 710032, China

REN Zhuan-qin* Department of Radiology, Baoji Municipal Central Hospital, Baoji 721008, China

*Correspondence to: Ren ZQ, E-mail: renzhuanqin@163.com

Conflicts of interest   None.

Received  2018-04-11
DOI: 10.12015/issn.1674-8034.2018.10.010
DOI:10.12015/issn.1674-8034.2018.10.010.

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