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• Clinical Article •
The application of three-dimensional T1 weighted imaging for detecting neonatal punctate white matter lesions
SUN Qin-li  ZHANG Yu-miao  GAO Jie  Ning Ning  WANG Miao-miao  LI Yan-yan  LI Huan  YANG Jian 

DOI:10.12015/issn.1674-8034.2018.11.001.


[Abstract] Objective: To compare the different for detecting neonatal punctate white matter lesions between three-dimensional T1 weighted imaging (3D-T1WI) and conventional MRI, diffusion imaging and susceptibility-weighted imaging, and to assess the value of 3D-T1WI sequence in the brain MR examination for neonates.Materials and Methods: Between March 2011 and February 2013, neonates with PWML underwent 3.0 T MRI exam were recruited. The routine protocol included 3D-T1WI, T2 weighted imaging (T2WI), diffusion tensor imaging (DTI) and 3D-enhanced susceptibility-weighted angiography (ESWAN). Reformatted T1WI (4 mm), apparent diffusion coefficient (ADC) map and magnitude image were obtained from 3D-T1WI, DTI and ESWAN, respectively. The numbers of PWML cases and lesions were calculated in all images independently.Results: (1) The number of cases that identified by 3D-T1WI, reformatted T1WI, T2WI, ADC maps and magnitude maps were 84 (100%), 69 (82.14%), 71 (84.52%), 73 (86.90%) and 70 (83.33%), respectively. (2) For 53 cases whose lesions can be counted, the total number of lesions detected by 3D-T1WI, reformatted T1WI, T2WI, ADC maps and magnitude maps were 422, 151, 185, 142 and 152, respectively. There are significant difference of the detectivity of punctate lesions between 3D T1WI and other MRI sequences (P<0.001). Comparing to 3D-T1WI, the detection rate of reformatted T1WI, T2WI, ADC maps and magnitude maps was 35.78% (151/422)、43.84% (185/422)、33.65% (142/422)、36.02% (152/422), respectively.Conclusions: The detection rate of punctate lesions in 3D T1WI is higher than that in other MRI sequences. It is greatly recommended to use 3D T1WI as a routine sequence for neonatal brain MR examination.
[Keywords] Neonate；Punctate white matter lesions；Magnetic resonance imaging

SUN Qin-li Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an 710061; Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710054, China

ZHANG Yu-miao Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an 710061

GAO Jie Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an 710061

Ning Ning Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an 710061

WANG Miao-miao Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an 710061

LI Yan-yan Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an 710061

LI Huan Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an 710061

YANG Jian* Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an 710061; Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710054, China

*Correspondence to: Yang J, Email: yj1118@mail.xjtu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This study was supported by the National Key Research and Development Program of China 2016YFC0100300 National Natural Science Foundation of China No. 81471631, 81771810 and 81171317 the 2011 New Century Excellent Talent Support Plan of the Ministry of Education, China NCET-11-0438 Shaanxi Provincial Natural Science Foundation for Youths of China No. 2017JQ8005 the Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University. No. XJTU1AF-CRF-2015-004 the Youth Innovation Fund No. 2011YK.19
Received  2018-06-29
DOI: 10.12015/issn.1674-8034.2018.11.001
DOI:10.12015/issn.1674-8034.2018.11.001.

[1]
Wagenaar N, Chau V, Groenendaal F, et al. Clinical risk factors for punctate white matter lesions on early magnetic resonance imaging in preterm newborns. J Pediatr, 2017, 182(3): 34-40.
[2]
Kersbergen KJ, Benders MJ, Groenendaal F, et al. Different patterns of punctate white matter lesions in serially scanned preterm infants. Plos One, 2014, 9(10): e108904.
[3]
de Bruine FT, van den Berg-Huysmans AA, Leijser LM, et al. Clinical implications of MR imaging findings in the white matter in very preterm infants: a 2-year follow-up study. Radiology, 2011, 261(3): 899-906.
[4]
高洁，张育苗，孙亲利，等．基于纤维束空间统计分析法研究早产及足月新生儿局灶性脑白质损伤的扩散张量成像特点．磁共振成像, 2014, 5(1): 24-29.
[5]
Childs AM, Cornette L, Ramenghi LA, et al. Magnetic resonance and cranial ultrasound characteristics of periventricular white matter abnormalities in newborn infants. Clin Radiol, 2001, 56(8): 647-655.
[6]
Cornette L, Tanner S, Ramenghi L, et al. Magnetic resonance imaging of the infant brain: anatomical characteristics and clinical significance of punctate lesions. Arch Dis Child Fetal Neonatal Ed, 2002, 86(3): 171-177.
[7]
Tortora D, Panara V, Mattei PA, et al. Comparing 3T T1-weighted sequences in identifying hyperintense punctate lesions in preterm neonates. AJNR Am J Neuroradiol, 2015, 36(3): 581-586.
[8]
Nanba Y, Matsui K, Aida N, et al. Magnetic resonance imaging regional T1 abnormalities at term accurately predict motor outcome in preterm infants. Pediatrics, 2007, 120(1): e10-19.
[9]
Cote CJ, Wilson S. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update. Pediatrics, 2006, 118(6): 2587-2602.
[10]
Rutherford MA, Supramaniam V, Ederies A, et al. Magnetic resonance imaging of white matter diseases of prematurityNeuroradiology, 2010, 52(6): 505-521.
[11]
Niwa T, de Vries LS, Benders MJ, et al. Punctate white matter lesions in infants: new insights using susceptibility-weighted imaging. Neuroradiology, 2011, 53(9): 669-679.
[12]
Nossin-Manor R, Chung AD, Morris D, et al. Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates. Pediatric Radiology, 2011, 41(6): 702.
[13]
Wintersperger BJ, Runge VM, Biswas J, et al. Brain tumor enhancement in MR imaging at 3 Tesla: comparison of SNR and CNR gain using TSE and GRE techniques. Invest Radiol, 2007, 42(8): 558-563.
[14]
Edelman RR, Dunkle EI. Rapid whole-brain magnetic resonance imaging with isotropic resolution at 3 Tesla. Invest Radiol, 2009, 44(1): 54-59.
[15]
祁英，王晓明．扩散加权成像在早期诊断早产儿局灶性脑白质损伤及其预后的价值．临床放射学杂志, 2010, 29(4): 515-518.
[16]
任慧鹏，张雷，任转琴，等. ESWAN-R2*值对比测量在新生儿局灶性脑白质损伤诊断中的价值．磁共振成像, 2013, 4(3): 201-205.
[17]
穆靓，杨健，鱼博浪．磁共振弥散加权及张量技术在新生儿缺血缺氧性脑病中的应用．磁共振成像, 2010, (1): 60-64.
[18]
Wisnowski JL, Blüml S, Paquette L, et al. Altered glutamatergic metabolism associated with punctate white matter lesions in preterm infants. Plos One, 2013, 8(2): e56880.

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