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• Clinical Article •
Predicting elevated CBF following carotid artery stenting and endarterectomy
LAN Yi-na  LÜ Jin-hao  MA Xiao-xiao  LOU Xin  MA Lin 

DOI:10.12015/issn.1674-8034.2018.11.002.


[Abstract] Objective: The purpose of this study was to predict elevated cerebral blood flow (CBF) by three-dimensional pseudo continuous arterial spin labeling (3D-pCASL) in patients who underwent carotid artery stenting (CAS) and endarterectomy (CEA), in the hope of providing a prognosis index for elevated CBF after CAS and CEA and thus to provide some references for the selection of surgical methods.Materials and Methods: Symptomatic eighteen patients [15 males and 3 females, age=(61.6±8.2) years] with 70%—99% unilateral internal carotid artery (ICA) stenosis were consecutively enrolled, of these, 11 underwent CAS and 7 underwent CEA in a prospective cross-sectional study from November 2015 to February 2017. Routine MRI examinations and 3D-pCASL were performed using a 3.0 T system within 7 days prior to operations, and at 4 consecutive time-points (24, 48, 72, and 96 h) after the operations. Pearson's correlation for the relationships between elevated flow, antegrade flow, and collateral flow was determined. P<0.05 was considered statistically significant.Results: Collateral flow showed a significant positive correlation with elevated CBF (r=0.877, P=0.000) after CAS, but no correlation with elevated CBF after CEA (r=-0.099, P=0.833), despite CEA had higher collateral flow than CAS (P<0.05). Antegrade flow showed a significant negative correlation with elevated CBF (r=-0.905, P=0.005) after CEA, while no correlation with elevated CBF after CAS (r=-0.317, P=0.342), when the antegrade flow is largely identical (P >0.05).Conclusions: Leptomenigeal collateral and antegrade flow effecting on the elevated CBF are different after CAS and CEA, which may provide some references for the selection of surgical methods.
[Keywords] Carotid artery stenting；Carotid endarterectomy；Cerebral blood flow；Three-dimensional pseudo-continuous arterial spin labeling

LAN Yi-na Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

LÜ Jin-hao Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

MA Xiao-xiao Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

LOU Xin Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

MA Lin* Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China

*Correspondence to: Ma L, E-mail: cjr.malin@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This study was funded by the National Key Research and Development Program of China No. 2016YFC01001004 the National Natural Science Foundation of China No. 81671126, 81730048
Received  2018-07-02
DOI: 10.12015/issn.1674-8034.2018.11.002
DOI:10.12015/issn.1674-8034.2018.11.002.

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