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• Clinical Article •
Quantitative MRI study of the relationship between fat content in lumbar paravertebral muscles and disc degeneration
WANG Yang  ZHA Yun-fei  XING Dong 

DOI:10.12015/issn.1674-8034.2018.11.004.


[Abstract] Objective: To investigate the relationship between paravertebral muscle fat content and intervertebral disc degeneration with quantitative MR technique.Materials and Methods: Fifty-seven patients (21 male, 36 female) with low back pain or sciatic were enrolled in this study. The lumbar imaging protocol included routine sagittal lumbar T2-weighted imaging (T2WI) imaging and axial iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation (IDEAL-IQ) sequence. Degeneration of lumbar intervertebral disc (IVD) were qualitatively evaluated by using Pfirrmann grading system in sagittal T2WI imaging. Fat fraction (FF) and cross-sectional area (CSA) were obtained from axial IDEAL-IQ imaging of lumbar to quantify fatty degeneration of bilateral lumbar multifidus muscle (MF), erector spinae muscle (ES), and psoas muscle (PS) at each disc level from L1 to S1 on AW 4.6 workstation. The paravertebral muscles were classified according to 5 Pfirrmann grades of the same level of IVD into 5 groups. Univariate analysis of variance (ANOVA) was employed to judge the difference of the FF and CSA of paravertebral muscles among these groups, Spearman correlation analysis was used to evaluate the correlation between Pfirrmann degeneration of IVD and degeneration of paravertebral muscles (FF and CSA), Multiple linear regression analysis was used to assess whether gender, age, degree of lumbar intervertebral disc degeneration were independent factors on paravertebral muscles degeneration, and P<0.05 was considered statistically significant.Results: There were significant differences in FF and CSA of paravertebral muscles between different IVD Pfirrmann grades. Pfirrmann grades of IVD were associated with the FF of PS, ES, and MF (correlation coefficients were 0.208, 0.392, 0.433, P values were less than 0.001), and were associated with the CSA of PS, ES and MF (correlation coefficients were 0.170,-0.284, 0.240, P values were 0.004, <0.001, <0.001). Gender, age and IVD Pfirrmann grades were independent factors impact on the FF of PS and MF. Pfirrmann grades of IVD were the independent factor influencing the FF of ES. Gender, age, and Pfirrmann grades of IVD were independent influencing factors of CSA of PS and MF. Gender and lumbar disc Pfirrmann grades were independent factors for the CSA of ES.Conclusions: There was a moderate correlation between the high fat content of ES and MF and the grade of IVD degeneration. Pfirrmann grades of IVD were the independent factors impact on the FF and CSA of PS, ES and MF.
[Keywords] Lumbar intervertebral disc degeneration；Muscle fat infiltration；Pfirrmann；Magnetic resonance imaging

WANG Yang Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

ZHA Yun-fei* Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

XING Dong Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, China

*Correspondence to: Zha YF, E-mail:zhayunfei999@126.com

Conflicts of interest   None.

Received  2018-06-17
DOI: 10.12015/issn.1674-8034.2018.11.004
DOI:10.12015/issn.1674-8034.2018.11.004.

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