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• Clinical Article •
To evaluate the oxygenation function of normal placenta and placenta accreta by BOLD-MRI
BAO Yu-wei  PANG Ying  SUN Zi-yan  LI Qian  XIA Li-ming 

DOI:10.12015/issn.1674-8034.2018.11.005.


[Abstract] Objective: Our study aimed to obtain the changes of oxygenation level and its distribution characteristics in normal placenta after hyper-oxygen inhalation. And to explore the effect of the placenta accreta on placental oxygenation function preliminarily.Materials and Methods: Total 25 cases of normal placenta and placental accreta were prospectively included in the study. Sixteen cases were confirmed for the normal placenta and 9 cases were placenta accreta by pathology/operation. All patients performed BOLD-MRI examination for 10 minutes. Pregnant women breathed room air during the first 3 minutes and oxygen for the last 7 minutes by mask. The region of interesting (ROI) was sketched by post-processing workstation of Siemens. The normal placenta was sketched the global placenta (Nor-p), the placenta-uteine side (Nor-u) and the placenta-uteine side (Nor-f) respectively in two planes well displayed. The implanted placenta sketched the global placenta (Imp-p) in well-displayed planes including the implanted site, and also the placenta-uterus side (Imp-u) and the placenta-fetal side(Imp-f) respectively. The renal parenchyma of pregnant women was sketched as Pre-r. The BOLD signal values increasing over time of each ROI were obtained and the signal increment percentage (△BOLD%) was calculated. The△BOLD%-time curves were drawn by SPSS 24.0 Compared the differences of △BOLD% in last 3 min of groups. Independent sample t test was used between the normal and implanted placenta, paired sample t test was used between the two sides of placenta.Results: After oxygen inhalation, the △BOLD%-time curve increased significantly during 4—7 min of each ROI except for Pre-r, then it leveled off. The △BOLD% in the last 3 min was obtained as the platform. The mean △BOLD% of Nor-f (16.25±1.3)% was higher than the Nor-u (12.89±1.2)%. The Imp-p (17.74±1.6)% was higher than Nor-p (14.38±1.2)%. And the △BOLD% of the Imp-f was higher than that of Imp-u, the △BOLD% of the Imp- f/u were higher than those of the Nor- f/u respectively. The t test showed that there were significance between control groups (P<0.01).Conclusions: BOLD-MRI can assess the physiological oxygenation status of the placenta and has a potential to detect changes in placental oxygenation semi-quantitatively. Moreover, implanted placenta lesions have no obvious damage to the oxygenation function of placental villi, which provides a certain basis for no clinical intervention of oxygen supply for cases of placenta accreta.
[Keywords] Placenta；Placenta Accreta；Magnetic resonance imaging

BAO Yu-wei Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

PANG Ying Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

SUN Zi-yan Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

LI Qian Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

XIA Li-ming* Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

*Correspondence to: Xia LM, E-mail: cjr.xialiming@vip.163.com

Conflicts of interest   None.

Received  2018-06-25
DOI: 10.12015/issn.1674-8034.2018.11.005
DOI:10.12015/issn.1674-8034.2018.11.005.

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