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Magnetic resonance imaging evaluation of axial bone in four cases with SAPHO syndrome
ZHANG Ya-nan  LI Jun-qiu  WEN Qing-xiang  YU Mei-yan  YANG Ying  CUI Can  ZHAO Lu-qing  ZHANG Qin  HUO Jian-wei 

DOI:10.12015/issn.1674-8034.2018.11.007.


[Abstract] Objective: To investigate MRI findings of axial bone in patients with SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) and its evaluation value.Materials and Methods: The MRI manifestations of anterior chest wall, whole spine and bilateral sacroiliac joint in 4 SAPHO patients were observed and analyzed.Results: In the current research, four patients all suffered from different degrees of the anterior chest wall involvement, mainly including sternoclavicular and manubriosternal joint. It was characterized by hyperostosis, osteosclerosis, bone marrow edema, joint narrowing and effusion, and soft tissue edema around sternoclavicular joints. A total of 40 vertebral bodies were involved in the whole spine. The most commonly affected site was the thoracic spine, followed by the lumbar spine, and finally the cervical spine. The abnormal signals of vertebral bodies included bone marrow edema, fat deposition and mixed signals. We also observed the vertebral corner and endplate involvement, facet joints involvement, intervertebral disc and corresponding space lesions. The thickening, fat deposition and bone bridge formation of the anterior longitudinal ligament were observed in two cases. Among the involved 3 cases, the lesions predominantly affected unilateral iliac bone. The abnormal MRI signals presented as bone marrow edema and osteosclerosis. The soft tissue edema in front of the right ilium was detected in one case.Conclusions: MRI could clearly reveal many lesions of axial bone in patients with SAPHO syndrome with certain characteristics. Bone marrow edema could be used to evaluate the activity of the disease and determine the condition, so as to guide clinical treatment and follow-up.
[Keywords] SAPHO syndrome；Magnetic resonance imaging；Thoracic wall；Spine；Sacroiliac joint

ZHANG Ya-nan Department of Radiology, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing 100010, China

LI Jun-qiu Department of Radiology, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing 100010, China

WEN Qing-xiang Department of Nuclear Medicine, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing 100010, China

YU Mei-yan Department of Radiology, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing 100010, China

YANG Ying Department of Radiology, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing 100010, China

CUI Can Department of Nuclear Medicine, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing 100010, China

ZHAO Lu-qing Department of Gastroenterology, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing 100010, China

ZHANG Qin Department of Rheumatology, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing 100010, China

HUO Jian-wei* Department of Radiology, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing 100010, China

*Correspondence to: Huo JW, E-mail: huojw1234@sina.com

Conflicts of interest   None.

Received  2018-07-17
DOI: 10.12015/issn.1674-8034.2018.11.007
DOI:10.12015/issn.1674-8034.2018.11.007.

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