Share：
Share this content in WeChat
X
[Chinese][PDF]76678
• Review •
Advance of magnetic resonance imaging in Parkinson's disease subtypes
WANG Juan  WEI Min  CHENG Ou-mei 

DOI:10.12015/issn.1674-8034.2018.11.010.


[Abstract] Parkinson's disease (PD) is a neurodegenerative disease caused by the selective loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), including both motor and non-motor symptoms. According to different motor symptoms, it’s usually divided into tremor dominant PD (TD-PD)/rigidity dominant PD (RD-PD) and tremor dominant PD (TD-PD)/postural instability gait difficulty PD (PIGD-PD). Available data indicate that there is a difference in the clinical course and prognosis of PD patients with different motor subtypes, that is, nTD-PD patients may have faster disease progression and are more prone to non-motor symptoms such as cognitive impairment. Therefore, understanding the potential pathogenesis of different motor subtypes is of great significance for the treatment and prognosis of patients. Magnetic resonance imaging (MRI), as a safe and non-invasive image detection technology, is increasingly being applied to the study of PD motor subtypes.
[Keywords] Parkinson disease；Subtypes；Magnetic resonance imaging；Review

WANG Juan Department of Neurology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China

WEI Min Department of Neurology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China

CHENG Ou-mei* Department of Neurology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China

*Corresponding to: Cheng OM, Email: chengoumei01@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  National Natural Science Foundation of China No. 81471334
Received  2018-07-18
DOI: 10.12015/issn.1674-8034.2018.11.010
DOI:10.12015/issn.1674-8034.2018.11.010.

[1]
Thenganatt MA, Jankovic J. Parkinson disease subtypes. Jama Neurol, 2014, 71(4): 499-504.
[2]
Kang GA, Bronstein JM, Masterman DL, et al. Clinical Characteristics in Early Parkinson's disease in a central california population-based study. Mov Disord, 2010, 20(9): 1133-1142.
[3]
Post B, Merkus MP, de Haan RJ, et al. Prognostic factors for the progression of Parkinson's disease: a systematic review. Mov Disord, 2010, 22(13): 1839-1851.
[4]
Keener AM, Paul KC, Folle A, et al. Cognitive impairment and mortality in a population-based Parkinson's disease cohort. J Parkinsons Dis, 2018, 8(2): 353-362.
[5]
Reijnders JS, Ehrt U, Lousberg R, et al. The association between motor subtypes and psychopathology in Parkinson's disease. Parkinsonism Relat Disord, 2009, 15(5): 379-382.
[6]
Ashburner J, Friston KJ. Voxel-based morphometry--the methods. Neuroimage, 2000, 11(6): 805-821.
[7]
Benninger DH, Thees S, Kollias SS, et al. Morphological differences in Parkinson's disease with and without rest tremor. J Neurol, 2009, 256(2): 256-263.
[8]
Piccinin CC, Campos LS, Guimarães RP, et al. Differential pattern of cerebellar atrophy in tremor-predominant and akinetic/rigidity-predominant Parkinson's disease. Cerebellum, 2016, 16(3): 1-6.
[9]
Herb J, Rane S, Isaacs D, et al. Cortical implications of advancing age and disease duration in Parkinson's disease patients with postural instability and gait dysfunction. J Parkinson's dis, 2016, 6(2): 441-451.
[10]
Rosenberg-Katz K, Herman T, Jacob Y, et al. Subcortical volumes differ in Parkinson's disease motor subtypes: new insights into the pathophysiology of disparate symptoms. Front Hum Neurosci, 2016, 10: 356.
[11]
Rosenbergkatz K, Herman T, Jacob Y, et al. Gray matter atrophy distinguishes between Parkinson disease motor subtypes. Neurology, 2013, 80(16): 1476-1484.
[12]
龚启勇，吕粟．功能磁共振成像临床应用及进展．磁共振成像, 2014, 5(增刊): 68-72.
[13]
Zang YF, He Y, Zhu CZ, et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Develop, 2007, 29(2): 83-91.
[14]
Hou Y, Zhang J, Chen B, et al. Local brain activity in different motor subtypes of Parkinson's disease with fMRI. Zhonghua Yi Xue Za Zhi, 2015, 95(7): 483-488.
[15]
Chen HM, Wang ZJ, Fang JP, et al. different patterns of spontaneous brain activity between tremor-dominant and postural instability/gait difficulty subtypes of Parkinson's disease: a resting-state fMRI study. Cns Neurosci Ther, 2015, 21(10): 855-866.
[16]
Zang Y, Jiang T, Lu Y, et al. Regional homogeneity approach to fMRI data analysis. Neuroimage, 2004, 22(1): 394-400.
[17]
Zhang J, Wei L, Hu X, et al. Akinetic-rigid and tremor-dominant Parkinson's disease patients show different patterns of intrinsic brain activity. Parkinsonism Relat Disord, 2015, 21(1): 23-30.
[18]
Jiang S, Min W, Li Z, et al. Regional homogeneity alterations differentiate between tremor dominant and postural instability gait difficulty subtypes of Parkinson's disease. J Neural Transm (Vienna), 2016, 123(3): 219-229.
[19]
Friston KJ, Frith CD, Liddle PF, et al. Functional connectivity: the principal-component analysis of large (PET) data sets. J Cereb Blood Flow Metab, 1993, 13(1): 5-14.
[20]
Liu H, Edmiston EK, Fan G, et al. Altered resting-state functional connectivity of the dentate nucleus in Parkinson's disease. Psychiatry Research Neuroimaging, 2013, 211(1): 64-71.
[21]
Ma H, Chen H, Fang J, et al. Resting-state functional connectivity of dentate nucleus is associated with tremor in Parkinson's disease. J Neurol, 2015, 262(10): 2247-2256.
[22]
Zhang JR, Feng T, Hou YN, et al. Functional connectivity of vim nucleus in tremor - and akinetic - ／rigid-dominant Parkinson's disease. Cns Neurosci Ther, 2016, 22(5): 378-386.
[23]
Wang Z, Chen H, Ma H, et al. Resting-state functional connectivity of subthalamic nucleus in different Parkinson's disease phenotypes. J Neurol Sci, 2016, 371: 137-147.
[24]
Hu X, Zhang J, Jiang X, et al. Decreased interhemispheric functional connectivity in subtypes of Parkinson's disease. J Neurol, 2015, 262(3): 760-767.
[25]
Hu X, Jiang Y, Jiang X, et al. Altered functional connectivity density in subtypes of Parkinson's disease. Front Hum Neurosci, 2017, 11: 458.
[26]
Guan X, Zeng Q, Guo T, et al. Disrupted functional connectivity of basal ganglia across tremor-dominant and akinetic/rigid-dominant Parkinson's disease. Front Aging Neurosci, 2017, 9: 360.
[27]
Karunanayaka PR, Lee EY, Lewis MM, et al. Default mode network differences between rigidity- and tremor-predominant Parkinson's disease. Cortex, 2016, 81: 239-250.
[28]
Eguiluz VM, Chialvo DR, Cecchi GA, et al. Scale-free brain functional networks. Phys Rev Lett, 2005, 94(1): 018102.
[29]
Zhang D, Liu X, Chen J, et al. Distinguishing patients with Parkinson's disease subtypes from normal controls based on functional network regional efficiencies. Plos One, 2014, 9(12): e115131.
[30]
Gu Q, Cao H, Xuan M, et al. Increased thalamic centrality and putamen–thalamic connectivity in patients with parkinsonian resting tremor. Brain Behav, 2017.7(1): e00601.
[31]
Ma LY, Chen XD, He Y, et al. Disrupted brain network hubs in subtype-specific Parkinson's disease. Eur Neurol2017, 78(3-4): 200-209.
[32]
Ogawa S, Lee TM, Kay AR, et al. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A, 1990, 87(24): 9868.
[33]
Lewis MM, Du G, Sen S, et al. Differential involvement of striato-and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease. Neuroscience, 2011, 177: 230-239.
[34]
Helmich RC, Bloem B, RToni I. Motor imagery evokes increased somatosensory activity in Parkinson's disease patients with tremor. Hum Brain Mapp, 2012, 33(8): 1763-1779.
[35]
Luo C, Song W, Chen Q, et al. White matter microstructure damage in tremor-dominant Parkinson's disease patients. Neuroradiology, 2017, 59(7): 691-698.
[36]
Barbagallo G, Caligiuri ME, Arabia G, et al. Structural connectivity differences in motor network between tremor-dominant and nontremor Parkinson's disease. Human Brain Mapp, 2017.38(9): 4716-4729.
[37]
Ciurleo R, Di LG, Bramanti P, et al. Magnetic resonance spectroscopy: an in vivo molecular imaging biomarker for Parkinson's disease?Biomed Res Int, 2014, 2014: 519816.
[38]
Gong T, Xiang Y, Saleh MG, et al. Inhibitory motor dysfunction in Parkinson's disease subtypes. J Magn Reson Imaging, 2018, 47(6): 1610-1615.
[39]
Sehgal V, Delproposto Z, Haacke EM, et al. Clinical applications of neuroimaging with susceptibility: weighted imaging. J Magn Reson Imaging, 2005, 22(4): 439-450.
[40]
Jin L, Wang J, Jin H, et al. Nigral iron deposition occurs across motor phenotypes of Parkinson's disease. Eur J Neurol, 2012, 19(7): 969-976.
[41]
Guan X, Xuan M, Gu Q, et al. Influence of regional iron on the motor impairments of Parkinson's disease: a quantitative susceptibility mapping study. J Magn Reson Imaging, 2016, 45(5): 1335-1342.
[42]
Xiang Y, Gong T, Wu J, et al. Subtypes evaluation of motor dysfunction in Parkinson's disease using neuromelanin-sensitive magnetic resonance imaging. Neurosci Lett, 2017, 638: 145-150.

PREV MRI of giant cervical and broad ligament myomatous degeneration 1 case
NEXT Advances in imaging studies of gender differences in depression
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn