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• Clinical Article •
Altered gray matter volume and the relationship with the psychiatric symptoms in methamphetamine use disorder
DANG Shan  ZHU Jia  LI Qiang  CHEN Jing  LIU Yan  CHEN Jia-jie  LI Xuan  LI Wei  WANG Wei 

DOI:10.12015/issn.1674-8034.2018.12.002.


[Abstract] Objective: To investigate dynamic contrast-enhanced MRI combined with DWI in differentiating non-mass breast cancer from granulomatous mastitis (GM).Materials and Methods: Twenty male methamphetamine use disorder based on DSM-V criteria and 21 male demography matched healthy controls participated in a study. 3D structural data were acquired on 3.0 T MRI system. The status of the psychology was evaluated by the self-reporting inventory-90 (SCL-90). The brain grey matter volume was measured by VBM based on SPM. The difference of grey matter volume between two groups was analyzed by two sample t-test. Partial correlation analysis was used to measure the relationship between grey matter volume and the SCL-90 scores as well as drug use situation in the methamphetamine group.Results: Higher score was found in MA group in extensive dimension, included interpersonal sensitivity, compulsion, depression, anxiety, hostility, paranoia and schizophrenia nuclear symptoms (P<0.05). Compared with HC, the grey matter volume of right cerebellum crus I, thalamus, postcentral gyrus and left middle frontal gyrus were decreased in MA group. The grey matter volume were increased in cerebellum vermis, right inferior occipital gyrus, left middle occipital gyrus and left supplementary motor area (AlphaSim corrected, P<0.01). Within the MA group, the grey matter volume in right thalamus was negatively correlated with the daily dose of methamphetamine (r=-0.528, P=0.036), the grey matter volume in cerebellum vermis was positively correlated with the schizophrenia nuclear symptoms (r=0.508, P=0.045), the grey matter volume in left supplementary motor area was positively correlated with the somatization (r=0.516, P=0.041).Conclusions: This study demonstrated that the grey matter volume was changed in MA group and was associated with the psychotic symptoms, which may contribute to the mechanism of MAP.
[Keywords] Methamphetamine；Voxel based morphometry；Gray matter；Psychological disorder；Magnetic resonance imaging

DANG Shan Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi’an 710038, China; Department of Radiology, Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China

ZHU Jia Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi’an 710038, China

LI Qiang Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi’an 710038, China

CHEN Jing Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi’an 710038, China; Department of Radiology, Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China

LIU Yan Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi’an 710038, China

CHEN Jia-jie Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi’an 710038, China

LI Xuan Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi’an 710038, China

LI Wei* Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi’an 710038, China

WANG Wei Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi’an 710038, China

*Correspondence to: Li W, E-mail: tdliwei@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation No. 81771813, 81401393, 81671661
Received  2018-07-09
DOI: 10.12015/issn.1674-8034.2018.12.002
DOI:10.12015/issn.1674-8034.2018.12.002.

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