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• Clinical Article •
To explore application value of FVHs in predicting the outcome of acute ischemic stroke
GENG Wen  JIANG Liang  CHEN Hui-you  XU Quan  XIE Guang-hui  YIN Xindao  ZHOU Jun-shan  ZHANG Ying-dong 

DOI:10.12015/issn.1674-8034.2018.12.003.


[Abstract] Objective: To explore application value of FVHs in predicting the outcome of acute ischemic stroke by analyzing the FLAIR vascular hyperintensities (FVHs) and digital subtraction angiography (DSA) medical image in acute ischemic stroke patients with definite onset time, in order to speculate the possibility of disability of AIS patients.Materials and Methods: AIS patients of onset time within 4.5 hours were enrolled, and all patients did MRI examination, including FLAIR sequences and were treated with thrombolysis and thrombectomy within 4.5 and 12 hours respectively. The patients were divided into 2 groups according to Modified Rankin Scale: ≤2(group A), >2(group B). The clinical information, DSA medical image and MRI findings between two groups were compared. The FLAIR vascular hyperintensity score was based on ASPECTS, ranging from 0(no FLAIR vascular hyperintensity) to 7(FLAIR vascular hyperintensities abutting all ASPECTS cortical areas). Collateral circulation was assessed according to the American society for interventional and therapeutic neuroradiology/society of interventional radiology (ASITN/SIR) collateral flow grading system: grade 0: no collaterals visible at the ischemic site; grade 1: slow collaterals to the periphery of the ischemic site with persistence of some of the defect; grade 2: rapid collaterals to the periphery of the ischemic site with persistence of some of the defect, and to only a portion of the ischemic territory; grade 3: collaterals with slow but complete angiographic blood flow of the ischemic bed by the late venous phase; and grade 4: complete and rapid collateral blood flow to the vascular bed in the entire ischemic territory by retrograde perfusion. Spearman nonparametric correlation were used to analyze to the relationship between FVHs and collateral circulation levels.Results: After comparing the two groups of FVHs and collateral circulation levels, there were significant differences between group A and group B: P1=0.002, P2=0.008. Spearman correlation analysis showed that FVHs was actively correlated with collateral circulation levels (r=0.364, P=0.032).Conclusions: FVHs was slightly correlated with collateral circulation levels, the prognosis of AIS patients may be speculated according to the FVHs, which has great guiding significance for clinical treatment.
[Keywords] Stroke；Fluid-attenuated inversion-recovery；Vascular hyperintensities；Collateral circulation；Diffusion weighted imaging；Magnetic resonance imaging

GENG Wen Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

JIANG Liang Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

CHEN Hui-you Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

XU Quan Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

XIE Guang-hui* Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

YIN Xindao Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

ZHOU Jun-shan Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

ZHANG Ying-dong Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

*Correspondence to: Xie GH, E-mail: skywaves@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Jiangsu Science and Technology Development Project No.BE2017614
Received  2018-08-22
DOI: 10.12015/issn.1674-8034.2018.12.003
DOI:10.12015/issn.1674-8034.2018.12.003.

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