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• Clinical Article •
Evaluation of myocardial microcirculation in diabetes patients by using intravoxel incoherent motion imaging: A pilot study
LI Shi-lan  MOU An-na  CHE Si-yu  CHEN Hui  SONG Qing-wei  LIU Ai-lian  LI Zhi-yong 

DOI:10.12015/issn.1674-8034.2018.12.004.


[Abstract] Objective: To preliminarily study myocardial microcirculation in diabetes patients using intravoxel incoherent motion (IVIM) imaging.Materials and Methods: 22 normal volunteers (10 male, mean age, 46.22±14.26 y) and 12 diabetic volunteers (6 male, mean age, 58.83±14.40 y) were enrolled in this study from May 2015 to November 2017. All of them performed CMR-IVIM on 3.0 T magnetic resonance on the middle of left ventricular short axis using multi b values (0, 20, 50, 80, 100, 120, 200, 300, 500 s/mm2). We measured IVIM parameters [apparent diffusion coefficient (ADC)fast, ADCslow, f (fraction of ADCfast)] and analyzed the difference of myocardial microcirculation between normal subjects and diabetes.Results: There was no significant difference in left ventricular structural [(LVEDV (left ventricular end-diastolic volume), LVESV (left ventricular end-systolic volume), LVmass] and function [LVEF (left ventricular ejection fraction), SV (stroke volume), CO (cardiac output), CI (cardiac index)] parameters between normal and diabetic subjects (P>0.05). ADCfast values in diabetic volunteers (0.12±0.02)×10-3 mm2/s were lower than normal volunteers (0.15±0.02)×10-3 mm2/s (P=0.01).Conclusions: It’s helpful to evaluate myocardial microcirculation in diabetic patients using IVIM imaging.
[Keywords] Magnetic resonance imaging；Intravoxel incoherent motion；Myocardial microcirculation；Diabetes

LI Shi-lan Dalian Medical University, Dalian 116011, China

MOU An-na Dalian Medical University, Dalian 116011, China

CHE Si-yu Dalian Medical University, Dalian 116011, China

CHEN Hui Dalian Medical University, Dalian 116011, China

SONG Qing-wei Dalian Medical University, Dalian 116011, China

LIU Ai-lian Dalian Medical University, Dalian 116011, China

LI Zhi-yong* Dalian Medical University, Dalian 116011, China

*Correspondence to: Li ZY, E-mail: zjy_lzy@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Research Foundation Project of Liaoning Education Department No. L2016021 Scientific Research Project of Liaoning Science and Technology Department No. 20170540235
Received  2018-07-22
DOI: 10.12015/issn.1674-8034.2018.12.004
DOI:10.12015/issn.1674-8034.2018.12.004.

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