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• Clinical Article •
Evaluation of myocardial microcirculation in diabetes patients by using intravoxel incoherent motion imaging: A pilot study
LI Shi-lan  MOU An-na  CHE Si-yu  CHEN Hui  SONG Qing-wei  LIU Ai-lian  LI Zhi-yong 

DOI:10.12015/issn.1674-8034.2018.12.004.


[Abstract] Objective: To preliminarily study myocardial microcirculation in diabetes patients using intravoxel incoherent motion (IVIM) imaging.Materials and Methods: 22 normal volunteers (10 male, mean age, 46.22±14.26 y) and 12 diabetic volunteers (6 male, mean age, 58.83±14.40 y) were enrolled in this study from May 2015 to November 2017. All of them performed CMR-IVIM on 3.0 T magnetic resonance on the middle of left ventricular short axis using multi b values (0, 20, 50, 80, 100, 120, 200, 300, 500 s/mm2). We measured IVIM parameters [apparent diffusion coefficient (ADC)fast, ADCslow, f (fraction of ADCfast)] and analyzed the difference of myocardial microcirculation between normal subjects and diabetes.Results: There was no significant difference in left ventricular structural [(LVEDV (left ventricular end-diastolic volume), LVESV (left ventricular end-systolic volume), LVmass] and function [LVEF (left ventricular ejection fraction), SV (stroke volume), CO (cardiac output), CI (cardiac index)] parameters between normal and diabetic subjects (P>0.05). ADCfast values in diabetic volunteers (0.12±0.02)×10-3 mm2/s were lower than normal volunteers (0.15±0.02)×10-3 mm2/s (P=0.01).Conclusions: It’s helpful to evaluate myocardial microcirculation in diabetic patients using IVIM imaging.
[Keywords] Magnetic resonance imaging；Intravoxel incoherent motion；Myocardial microcirculation；Diabetes

LI Shi-lan Dalian Medical University, Dalian 116011, China

MOU An-na Dalian Medical University, Dalian 116011, China

CHE Si-yu Dalian Medical University, Dalian 116011, China

CHEN Hui Dalian Medical University, Dalian 116011, China

SONG Qing-wei Dalian Medical University, Dalian 116011, China

LIU Ai-lian Dalian Medical University, Dalian 116011, China

LI Zhi-yong* Dalian Medical University, Dalian 116011, China

*Correspondence to: Li ZY, E-mail: zjy_lzy@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Research Foundation Project of Liaoning Education Department No. L2016021 Scientific Research Project of Liaoning Science and Technology Department No. 20170540235
Received  2018-07-22
DOI: 10.12015/issn.1674-8034.2018.12.004
DOI:10.12015/issn.1674-8034.2018.12.004.

[1]
Guariguata L, Whiting DR, Hambleton I, et al. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract, 2014, 103(2): 137-149.
[2]
Brodsky SV, Morrishow AM, Dharia N, et al. Glucose scavenging of nitric oxide. Am J Physiol Renal Physiol, 2001, 280(3): 480-486.
[3]
刘诗珍，沈学东，陈灏珠．糖尿病对冠脉及心肌微循环的影响．中国临床医学, 2003, 10(2): 264-267.
[4]
Le Bihan D, Breton E, Lallemand D, et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology, 1986, 161(2): 401-407.
[5]
Winfield JM, Orton MR, Collins DJ, et al. Separation of type and grade in cervical tumours using non-mono-exponential models of diffusion-weighted MRI. Eur Radiol, 2017, 27(2): 627-636.
[6]
Liu C, Liang C, Liu Z, et al. Intravoxel incoherent motion (IVIM) in evaluation of breast lesions: comparison with conventional DWI. Eur J Radiol, 2013, 82(12): e782-789.
[7]
Luo M, Zhang L, Jiang XH, et al. Intravoxel incoherent motion diffusion-weighted imaging: Evaluation of the differentiation of solid hepatic lesions. Transl Oncol, 2017, 10(5): 831-838.
[8]
Mou A, Zhang C, Li M, et al. Evaluation of myocardial microcirculation using intravoxel incoherent motion imaging. J Magn Reson Imaging, 2017, 46(6): 1818-1828.
[9]
Wang L, Zhu HY, Tian JM, et al. Magnetic resonance imaging in determination of myocardial ischemia and viability: comparison with positron emission tomography and single-photon emission computed tomography in a porcine model. Acta Radiol, 2007, 48(5): 500-507.
[10]
李志伟，袁思殊，黄璐，等．心肌磁共振多b值DWI的初步探讨．放射学实践, 2013, 28(3): 337-340.
[11]
Callot V, Bennett E, Decking UK, et al. In vivo study of microcirculation in canine myocardium using the IVIM method. Magn Reson Med, 2003, 50(3): 531-540.

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