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• Clinical Article •
The diagnostic value of mp-MRI for detecting transition zone prostate cancer based on PI-RADS V2
PENG Feng-he  SHEN Xiu-zhi  CAI Jian-xin  LI Yan-cui  KONG Guang-qi  PENG Ru-chen 

DOI:10.12015/issn.1674-8034.2018.12.008.


[Abstract] Objective: To investigate the diagnostic value of multiparametric MRI (mp-MRI) for detecting clinically significant transition zone prostate cancer (TZ-PCa) based on prostate imaging-reporting and data system version 2 (PI-RADS V2).Materials and Methods: Totally 105 patients undergoing prostate mp-MRI consisting of T2WI, diffusion weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) were included and analyzed retrospectively. Among them 41 were confirmed TZ-PCa, 64 benign prostatic hyperplasia (BPH) by pathology within ≤1 week from MRI. T2WI, DWI, DCE-MRI and mp-MRI (T2WI+DWI) were scored based on PI-RADS V2 by two diagnostic physicians, as well as calculating their sensitivity and specificity taking pathological results as gold standard. Receiver operating characteristic (ROC) curve was drawn and the area under curve (AUC) was performed to analyze the diagnostic efficiency of TZ-PCa with different protocols.Results: Inter-observer agreement of PI-RADS V2 score was good (Kappa value=0.83). The AUC of T2WI, DWI, DCE-MRI and mp-MRI for the diagnosis of TZ-PCa with PI-RADS V2 were 0.914, 0.887, 0.773, 0.927, respectively. The AUC was not statistically significant difference between T2WI and mp-MRI (P=0.107), and statistically significant difference of AUC was found between the rest of each other scan protocols. The sensitivity and specificity were 85.4%, 84.4% for T2WI alone, 78.0%, 81.3% for DWI alone, 78.0%, 76.6% for DCE-MRI alone and 92.7%, 83.9% for mp-MRI.Conclusions: Multiparametic MRI based on PI-RADS V2 has important guiding significance in diagnosis of clinically significant transition zone prostate cancer.
[Keywords] Prostatic neoplasms；Transition zone；Magnetic resonance imaging；Prostate imaging-reporting and data system

PENG Feng-he Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China

SHEN Xiu-zhi Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China

CAI Jian-xin Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China

LI Yan-cui Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China

KONG Guang-qi Department of Urology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China

PENG Ru-chen* Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China

*Correspondence to: Peng RC, E-mail: 13501271260@163.com

Conflicts of interest   None.

Received  2018-03-08
DOI: 10.12015/issn.1674-8034.2018.12.008
DOI:10.12015/issn.1674-8034.2018.12.008.

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