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• Clinical Article •
A diffusion kurtosis imaging study of early injury on the white matter of the bilateral temporal lobes and the hippocampus after radiotherapy in nasopharyngeal carcinoma patients
CHEN Hong  HE Haoqiang  LÜ Xiaofei  HAN Lujun  YANG Yadi  Li Jing  WEN Ge 

Cite this article as: Chen H, He HQ, Lü XF, et al. A diffusion kurtosis imaging study of early injury on the white matter of the bilateral temporal lobes and the hippocampus after radiotherapy in nasopharyngeal carcinoma patients. Chin J Magn Reson Imaging, 2019, 10(1): 1-7. DOI:10.12015/issn.1674-8034.2019.01.001.


[Abstract] Objective: To explore the early microstructure changes on the white matter of the bilateral temporal lobes and the hippocampus after radiotherapy (RT) in nasopharyngeal carcinoma (NPC) patients by using diffusion kurtosis imaging (DKI).Materials and Methods: Twenty-nine NPC patients (NPC group) and 20 normal controls (NC group) were included in this study. The NPC group was followed up prior to the initiation of the treatment and 3 months post-RT. Each participant in NPC group and NC group underwent DKI sequence scanning. Then the DKI parameter figures were obtained and the DKI parameter values in the white matter of the bilateral temporal lobes and the hippocampus were measured. The differences in DKI parameter values between NPC patients prior treatment and NC subjects, between NPC patients prior treatment and 3 months post-RT were analyzed. For NPC group, the correlation between these alternations and Montreal cognitive assessment scale scores, as well as the radiation dosage were also investigated.Results: There were no significant differences in all DKI parameter values between NPC patients prior treatment and NC subjects. Compared with NPC patients prior treatment, the fractional anisotropy (FA) (right: P=0.009. left: P=0.001), mean kurtosis (MK) (right: P=0.027. left: P=0.034) and radial kurtosis (Kr) (right: P=0.007. left P=0.007) values of the white matter of bilateral temporal lobes in the NPC patients 3 months post-RT were significantly reduced. While the MK (P=0.033) and Kr (Kr: P=0.031) values of the right hippocampus in the NPC patients 3 months post-RT were significantly increased. In NPC group, the changes of the MK (r=0.407, P=0.044) and Kr values (r=0.530, P=0.006) in the white matter of the left temporal lobe in the NPC group were significantly correlated with the maximum dose of left temporal lobe.Conclusions: DKI can reflect the early microstructure changes of the white matter of the bilateral temporal lobes and the hippocampus post-RT in NPC patients, which could provide objective imaging evidences for early radiation-induced brain injury of the temporal lobes in NPC patients.
[Keywords] nasopharyngeal neoplasms；radiotherapy；brain injuries；magnetic resonance imaging

CHEN Hong Medical Imaging Center, Nanfang Hospital of Southern Medical University, GuangZhou 510050, China; Department of Medical Imaging and Interventional Radiology, Cancer Center of Sun Yat-sen University, State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China

HE Haoqiang Department of Medical Imaging and Interventional Radiology, Cancer Center of Sun Yat-sen University, State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China

LÜ Xiaofei Department of Medical Imaging and Interventional Radiology, Cancer Center of Sun Yat-sen University, State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China

HAN Lujun Department of Medical Imaging and Interventional Radiology, Cancer Center of Sun Yat-sen University, State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China

YANG Yadi Department of Medical Imaging and Interventional Radiology, Cancer Center of Sun Yat-sen University, State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China

Li Jing Department of Medical Imaging and Interventional Radiology, Cancer Center of Sun Yat-sen University, State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China

WEN Ge* Medical Imaging Center, Nanfang Hospital of Southern Medical University, GuangZhou 510050, China

*Correspondence to: WEN G, E-mail: wenge1967@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Nature Science Foundation of China No. 81401399
Received  2018-08-03
Accepted  2018-11-20
DOI: 10.12015/issn.1674-8034.2019.01.001
Cite this article as: Chen H, He HQ, Lü XF, et al. A diffusion kurtosis imaging study of early injury on the white matter of the bilateral temporal lobes and the hippocampus after radiotherapy in nasopharyngeal carcinoma patients. Chin J Magn Reson Imaging, 2019, 10(1): 1-7. DOI:10.12015/issn.1674-8034.2019.01.001.

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