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• Clinical Article •
Intravoxel incoherent motion diffusion weighted imaging as an imaging biomarker to predict the Ki-67 expression in non-small cell lung cancer patients
DANG Shan  SHI Weihua  HAN Dong  MA Guangming  YANG Qi  DUAN Haifeng  YU Yong  ZHAO Jing  YU Nan  WANG Shaoyu 

Cite this article as: Dang S, Shi WH, Han D, et al. Intravoxel incoherent motion diffusion weighted imaging as an imaging biomarker to predict the Ki-67 expression in non-small cell lung cancer patients. Chin J Magn Reson Imaging, 2019, 10(1): 18-22. DOI:10.12015/issn.1674-8034.2019.01.004.


[Abstract] Objective: To evaluate the capacity of noninvasive intravoxel incoherent motion diffusion weighted imaging (IVIM) parameters (perfusion fraction (f), pseudo diffusion coefficient (D*), true diffusion coefficient (D) and apparent diffusion coefficient (ADC) value in preoperative predicting the Ki-67 expression in non-small cell lung cancer.Materials and Methods: The institutional review board approved this study, and written informed consent was obtained from each patient. The IVIM (b=0, 50, 100, 150, 200, 400, 600, 800 s/mm2) and diffusion weighted imaging (DWI, b=50, 800 s/mm2) were used to examine 60 patients (41 males, 19 females, 35—81 years old) with a 3.0 T scanner. All patients had received a histopathologic diagnosis of lung cancer based on bronchoscopy, percutaneous needle-guided, or surgical biopsies, all of them had undergone immunohistochemistry staining. ADC, D, f and D* were generated by using a prototype software body diffusion toolbox, two radiologists drew the region of interest on the parametric maps. The areas of focal necrosis, large vessels, and prominent artifacts were avoided carefully. Each lesion was measured for three times. The correlation between ADC, D, D*, f value and Ki-67 expression is calculated by Spearman correlation.Results: The ADC and D value of non-small cell lung cancer was negatively correlated with the Ki-67 expression (ADC value: r=-0.335, P=0.009)(D: r=-0.330, P=0.01). The ADC value of lung adenocarcinoma was negatively correlated with the Ki-67 expression (r=-0.424, P=0.008).Conclusions: The ADC and D value would be an imaging biomarker for the prediction of tumor aggressiveness indicators such as Ki-67 in non-small cell lung cancer.
[Keywords] carcinoma, non-small-cell lung；magnetic resonance imaging；Ki-67 antigen

DANG Shan Department of Radiology, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Xianyang 712000, China

SHI Weihua Department of Radiology, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Xianyang 712000, China

HAN Dong Department of Radiology, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Xianyang 712000, China

MA Guangming Department of Radiology, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Xianyang 712000, China

YANG Qi Department of Radiology, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Xianyang 712000, China

DUAN Haifeng Department of Radiology, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Xianyang 712000, China

YU Yong Department of Radiology, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Xianyang 712000, China; Shanxi University of Traditional Chinese Medicine, Xianyang 712046, China

ZHAO Jing Department of Radiology, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Xianyang 712000, China

YU Nan* Department of Radiology, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Xianyang 712000, China; Shanxi University of Traditional Chinese Medicine, Xianyang 712046, China

WANG Shaoyu MR Scientific Marketing, Siemens Healthineers, Xi'an 710077, China

*Correspondence to: Yu N, Email: yunan0512@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This paper is funded by the National Natural Science Foundation No. 81701691
Received  2018-08-07
Accepted  2018-11-20
DOI: 10.12015/issn.1674-8034.2019.01.004
Cite this article as: Dang S, Shi WH, Han D, et al. Intravoxel incoherent motion diffusion weighted imaging as an imaging biomarker to predict the Ki-67 expression in non-small cell lung cancer patients. Chin J Magn Reson Imaging, 2019, 10(1): 18-22. DOI:10.12015/issn.1674-8034.2019.01.004.

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