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• Clinical Article •
Application of the magnetic resonance kurtosis imaging on human kidneys
CHENG Zhongyuan  FENG Youzhen  YE Yaojiang  HU Junjiao  CAI Xiangran 

Cite this article as: Cheng ZY, Feng YZ, Ye YJ, et al. Application of the magnetic resonance kurtosis imaging on human kidneys. Chin J Magn Reson Imaging, 2019, 10(1): 37-41. DOI:10.12015/issn.1674-8034.2019.01.007.


[Abstract] Objective: To investigate the feasibility of magnetic resonance diffusion kurtosis imaging (DKI) applies on human kidneys.Materials and Methods: Thirty healthy male volunteers were recruited in our hospital from March 2016 to February 2017. The MR examination was performed in the coronal plane with a 3.0 T MR scanner. The scanning sequences included T1WI, T2WI and DKI. The DKI sequence used three different b values (0, 500 s/mm2, 1000 s/mm2) and 30 diffusion-sensitive gradient directions. The paired-samples t test was used to compare the DKI parameters of the renal cortex and medulla. The correlated between all parameters with estimated glomerular filtration rate (eGFR) were calculated.Results: The mean kurtosis (MK), axial kurtosis (Ka) and radial kurtosis (Kr) values in renal cortex were greater than those in renal medulla (P<0.05). The fractional anisotropy (FA) and axial diffusion (Da) values of renal cortex were significantly lower than those of renal medulla (P<0.05), while the mean diffusion (MD) and radial diffusion (Dr) values of renal cortex were greater than those of renal medulla (P<0.05).Conclusions: DKI is feasible in human kidney. It can reflect the water molecule diffusion differences between the renal cortex and medulla. Furthermore, its unique kurtosis parameters can also provide microstructure information on renal cortex and medulla.
[Keywords] kidney；diffusion-weighted imaging；diffusion kurtosis imaging；magnetic resonance imaging

CHENG Zhongyuan Medical Imaging Center, the First Affiliated Hospital of Jinan University , Guangzhou 510630, China

FENG Youzhen Medical Imaging Center, the First Affiliated Hospital of Jinan University , Guangzhou 510630, China

YE Yaojiang Medical Imaging Center, the First Affiliated Hospital of Jinan University , Guangzhou 510630, China

HU Junjiao Medical Imaging Center, the First Affiliated Hospital of Jinan University , Guangzhou 510630, China

CAI Xiangran* Medical Imaging Center, the First Affiliated Hospital of Jinan University , Guangzhou 510630, China

*Correspondence to: Cai XR, E-mail: caixran@jnu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  Nature Science Foundation of Guangdong No. 2017A030313901 Science and Technology Project of Guangzhou No. 201804010239
Received  2018-07-17
Accepted  2018-11-20
DOI: 10.12015/issn.1674-8034.2019.01.007
Cite this article as: Cheng ZY, Feng YZ, Ye YJ, et al. Application of the magnetic resonance kurtosis imaging on human kidneys. Chin J Magn Reson Imaging, 2019, 10(1): 37-41. DOI:10.12015/issn.1674-8034.2019.01.007.

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