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• Original Article •
A joint assessment in myocardial ischemia by cardiac magnetic resonance and biomarkers
HOU Jie  SUN Yu  XIAO Junrui  YANG Zhonglu  ZOU Mingyu  ZHANG Libo  LI Xiaogang  YANG Benqiang 

Cite this article as: Hou J, Sun Y, Xiao JR, et al. A joint assessment in myocardial ischemia by cardiac magnetic resonance and biomarkers. Chin J Magn Reson Imaging, 2019, 10(1): 48-52. DOI:10.12015/issn.1674-8034.2019.01.009.


[Abstract] Objective: The purpose of this study is to investigate the clinical value of cardiac magnetic resonance (CMR) and biomarkers in evaluating myocardial ischemia.Materials and Methods: Seven pigs of myocardial ischemia modol were successfully established, CMR and biomarkers checks were performed pre-surgery and post-surgery at 2 h, 12 h, 24 h, 48 h, 72 h, 1 w, 2 w, 3 w, 4 w, respectively. And pathologic histology was given at last.Results: Bama-pigs' cardiac troponin I and myoglobin levels significantly increased in 2 h compared with the baseline results [(0.005±0.002) ng/ml vs. (0.338±0.768) ng/ml, (110.3±53.7) ng/ml vs. (1012±1300) ng/ml, P<0.05, respectively], all the markers for the extent of the myocardial injury increased in 72 h after modeling (all P<0.05), which indicated myocardial injury, and gradually to be stable after 1 week post-surgery. At the early stage of ischemia, T2 weighted imaging (T2WI) CMR showed the myocardial edema, which was also called area at risk. Cine showed the abnormal wall motion. First-pass perfusion imaging showed the hypoperfusion or perfusion defect at 2 h, delayed enhancement CMR showed the high signal at 24 h, and transmural extent increased with the prolongation of ischemic time, which were confirmed by pathological findings of necrotic myocardium and myocardial fibrosis at last. Cardiac function measured by CMR dropped significantly 4 w after modeling (left ventricular ejection fraction%: 62.71±8.33 vs. 45.97±6.37, P<0.05).Conclusions: Myocardial enzyme spectrum, cardiac troponin I and myoglobin can indicate the myocardial injury, CMR can exactly reveal micro-histological changes of myocardial ischemia, joint assessment is of great significance in providing detailed prognosis information and guiding treatment options.
[Keywords] myocardial ischemia；myocardial enzyme spectrum；magnetic resonance imaging；delayed enhancement

HOU Jie Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

SUN Yu Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

XIAO Junrui Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

YANG Zhonglu Department of Cardiac surgery, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

ZOU Mingyu Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

ZHANG Libo Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

LI Xiaogang Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

YANG Benqiang* Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

*Correspondence to: Yang BQ, E-mail: bqyang888@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Liaoning Province Research and Development of Domestic Medical Equipment, Evaluation and Promotion of Collaborative Innovation Project No. 2015305010 Project of National Ministry of Industry and Information, National Health and Family Planning Commission of China No. 2016MHD110002002101 Sub subject of Liaoning Province science and technology planning project No. 2014305006
Received  2018-08-11
Accepted  2018-11-21
DOI: 10.12015/issn.1674-8034.2019.01.009
Cite this article as: Hou J, Sun Y, Xiao JR, et al. A joint assessment in myocardial ischemia by cardiac magnetic resonance and biomarkers. Chin J Magn Reson Imaging, 2019, 10(1): 48-52. DOI:10.12015/issn.1674-8034.2019.01.009.

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