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• Original Article •
A joint assessment in myocardial ischemia by cardiac magnetic resonance and biomarkers
HOU Jie  SUN Yu  XIAO Junrui  YANG Zhonglu  ZOU Mingyu  ZHANG Libo  LI Xiaogang  YANG Benqiang 

Cite this article as: Hou J, Sun Y, Xiao JR, et al. A joint assessment in myocardial ischemia by cardiac magnetic resonance and biomarkers. Chin J Magn Reson Imaging, 2019, 10(1): 48-52. DOI:10.12015/issn.1674-8034.2019.01.009.


[Abstract] Objective: The purpose of this study is to investigate the clinical value of cardiac magnetic resonance (CMR) and biomarkers in evaluating myocardial ischemia.Materials and Methods: Seven pigs of myocardial ischemia modol were successfully established, CMR and biomarkers checks were performed pre-surgery and post-surgery at 2 h, 12 h, 24 h, 48 h, 72 h, 1 w, 2 w, 3 w, 4 w, respectively. And pathologic histology was given at last.Results: Bama-pigs' cardiac troponin I and myoglobin levels significantly increased in 2 h compared with the baseline results [(0.005±0.002) ng/ml vs. (0.338±0.768) ng/ml, (110.3±53.7) ng/ml vs. (1012±1300) ng/ml, P<0.05, respectively], all the markers for the extent of the myocardial injury increased in 72 h after modeling (all P<0.05), which indicated myocardial injury, and gradually to be stable after 1 week post-surgery. At the early stage of ischemia, T2 weighted imaging (T2WI) CMR showed the myocardial edema, which was also called area at risk. Cine showed the abnormal wall motion. First-pass perfusion imaging showed the hypoperfusion or perfusion defect at 2 h, delayed enhancement CMR showed the high signal at 24 h, and transmural extent increased with the prolongation of ischemic time, which were confirmed by pathological findings of necrotic myocardium and myocardial fibrosis at last. Cardiac function measured by CMR dropped significantly 4 w after modeling (left ventricular ejection fraction%: 62.71±8.33 vs. 45.97±6.37, P<0.05).Conclusions: Myocardial enzyme spectrum, cardiac troponin I and myoglobin can indicate the myocardial injury, CMR can exactly reveal micro-histological changes of myocardial ischemia, joint assessment is of great significance in providing detailed prognosis information and guiding treatment options.
[Keywords] myocardial ischemia；myocardial enzyme spectrum；magnetic resonance imaging；delayed enhancement

HOU Jie Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

SUN Yu Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

XIAO Junrui Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

YANG Zhonglu Department of Cardiac surgery, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

ZOU Mingyu Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

ZHANG Libo Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

LI Xiaogang Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

YANG Benqiang* Department of Radiology, General Hospital of Northern Theater Conmmand, Shenyang 110016, China

*Correspondence to: Yang BQ, E-mail: bqyang888@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Liaoning Province Research and Development of Domestic Medical Equipment, Evaluation and Promotion of Collaborative Innovation Project No. 2015305010 Project of National Ministry of Industry and Information, National Health and Family Planning Commission of China No. 2016MHD110002002101 Sub subject of Liaoning Province science and technology planning project No. 2014305006
Received  2018-08-11
Accepted  2018-11-21
DOI: 10.12015/issn.1674-8034.2019.01.009
Cite this article as: Hou J, Sun Y, Xiao JR, et al. A joint assessment in myocardial ischemia by cardiac magnetic resonance and biomarkers. Chin J Magn Reson Imaging, 2019, 10(1): 48-52. DOI:10.12015/issn.1674-8034.2019.01.009.

[1]
Chapman AR, Adamson PD, Mills NL. Assessment and classification of patients with myocardial injury and infarction in clinical practice. Heart, 2017, 103(1): 10-18.
[2]
Kwong RY, Schussheim AE, Rekhraj S, et al. Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging. Circulation, 2003, 107(4): 531-537.
[3]
Lukács E, Magyari B, Tóth L, et al. Overview of large animal myocardial infarction models. Acta physiologica Hungarica, 2012, 99(4): 365-381.
[4]
Suzuki Y, Yeung AC, Ikeno F. The representative porcine model for human cardiovascular disease. J Biomed Biotechnol, 2010, 2011: 195483.
[5]
侯洁，肖俊睿，孙玉，等．心肌标记技术在心肌缺血中的应用价值．功能与分子医学影像学杂志（电子版）, 2018(1): 1359-1362.
[6]
赵世华，蒋世良，陆敏杰．心血管病磁共振诊断学．北京：人民军医出版社, 2010: 74-75.
[7]
Saeed M, Van TA, Krug R, et al. Cardiac MR imaging: current status and future direction. Cardiovasc Diagn ther, 2015, 5(4): 290-310.
[8]
Hundley WG, Bluemke DA, Finn JP, et al. ACCF/ACR/AHA/NASCI/SCMR 2010 expert consensus document on cardiovascular magnetic resonance: a report of the American college of cardiology foundation task force on expert consensus documents. J Am Coll Cardiol, 2010, 55(23): 2614-2662.
[9]
侯洁，肖俊睿，孙玉，等．次全结扎冠状动脉法构建猪心肌缺血模型.中国介入影像与治疗学, 2018, 15(9): 561-565.
[10]
Pipikos T, Kapelouzou A, Tsilimigras DI, et al. Stronger correlation with myocardial ischemia of high-sensitivity troponin T than other biomarkers. J Nucl Cardiol, 2018(76): 1-10.
[11]
Aldous SJ. Cardiac biomarkers in acute myocardial infarction. Int J Cardiol, 2013, 164(3): 282-294.
[12]
McCann CJ, Glover BM, Menown IB A, et al. Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T. Eur Heart J, 2008, 29(23): 2843-2850.
[13]
Cury RC, Shash K, Nagurney JT, et al. Cardiac magnetic resonance with T2-weighted imaging improves detection of patients with acute coronary syndrome in the emergency department. Circulation, 2008, 118(8): 837-844.
[14]
Lønborg J, Vejlstrup N, Mathiasen AB, et al. Myocardial area at risk and salvage measured by T2-weighted cardiovascular magnetic resonance: reproducibility and comparison of two T2-weighted protocols. J Cardiovascr Magn Reson, 2011, 13(1): 50.
[15]
Kalam K, Otahal P, Marwick TH. Prognostic implications of global LV dysfunction: a systematic review and meta-analysis of global longitudinal strain and ejection fraction. Heart, 2014, 100(21): 1673-1680.
[16]
Thavendiranathan P, Poulin F, Lim KD, et al. Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review. J Am Coll Cardiol, 2014, 63(25): 2751-2768.
[17]
Bogarapu S, Puchalski MD, Everitt MD, et al. Novel cardiac magnetic resonance feature tracking (CMR-FT) analysis for detection of myocardial fibrosis in pediatric hypertrophic cardiomyopathy. Pediatr Cardiol, 2016, 37(4): 663-673.
[18]
Mather AN, Fairbairn TA, Artis NJ, et al. Timing of cardiovascular MR imaging after acute myocardial infarction: effect on estimates of infarct characteristics and prediction of late ventricular remodeling. Radiology, 2011, 261(1): 116-126.
[19]
Wu E, Ortiz JT, Tejedor P, et al. Infarct size by contrast enhanced cardiac magnetic resonance is a stronger predictor of outcomes than left ventricular ejection fraction or end-systolic volume index: prospective cohort study. Heart, 2008, 94(6): 730-736.
[20]
Haberkorn SM, Jacoby C, Ding Z, et al. Cardiovascular magnetic resonance relaxometry predicts regional functional outcome after experimental myocardial infarction. Circ Cardiovasc Imaging, 2017, 10(8). DOI: .
[21]
Bulluck H, Hammond-Haley M, Weinmann S, et al. Myocardial infarct size by CMR in clinical cardioprotection studies: insights from randomized controlled trials. JACC Cardiovasc Imaging, 2017, 10(3): 230-240.

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