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• Clinical Article •
Prediction of lymph vascular space invasion in cervical squamous cell carcinoma by using volumetric dynamic contrast-enhanced MRI
BAI Zhiqiang  SHI Jie  DUAN Xiaohui  SHEN Jun 

Cite this article as: Bai ZQ, Shi J, Duan XH, et al. Prediction of lymph vascular space invasion in cervical squamous cell carcinoma by using volumetric dynamic contrast-enhanced MRI. Chin J Magn Reson Imaging, 2019, 10(2): 145-149. DOI:10.12015/issn.1674-8034.2019.02.014.


[Abstract] Objective: To investigate the value of semi-quantitative and quantitative parameters derived from volumetric quantitative dynamic contrast-enhanced MRI (qDCE-MRI) in the prediction of lymph vascular space invasion (LVSI) of the cervical squamous cell carcinoma.Materials and Methods: 25 patients who were newly diagnosed with cervical squamous cell carcinoma which was proved by surgical pathology were enrolled in Sun Yat-sen memorial hospital between July 2017 and March 2018. All patients were staged higher than IA and underwent conventional MRI and qDCE-MRI before surgery. Semi-quantitative parameters including time to peak (TTP), maximum slope (MaxSlope), area under curve (AUC) of time-concentration curve, maximum concentration (MaxCon) and quantitative parameters including volume transfer constant (Ktrans), efflux rate constant (Kep), extracellular-extravascular volume fraction (Ve), plasma volume fraction (Vp) were derived from DCE-MRI data by using the extended TOFT pharmaceutical kinetic model. The differences of these parameters between patients with or without LVSI were analyzed using Mann-Whitney test. The predictive performance of parameters was analyzed by receiving operating characteristic curve (ROC).Results: Among parameters derived from DCE-MRI, there was statistical difference between LVSI positive and negative groups in AUC (P=0.046). AUC was 2.012±1.969 in LVSI negative group and 3.188±1.993 in LVSI positive group. With 1.258 as threshold value, the accuracy, sensitivity and specificity of AUC in predicting the diagnosis of LVSI was 0.760, 0.900 and 0.667, respectively. The area under ROC was 0.740. There was no statistical difference in the other parameters between LVSI negative group and positive group (P>0.05).Conclusions: Semi-quantitative parameter AUC of qDCE-MRI can be used to predict the LVSI in patients with cervical squamous cell carcinoma.
[Keywords] cervical squamous cell carcinoma；dynamic contrast enhancement；magnetic resonance imaging；lymph vascular space invasion

BAI Zhiqiang Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

SHI Jie Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

DUAN Xiaohui Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

SHEN Jun* Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

*Correspondence to: Shen J, E-mail: shenjun@mail.sysu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Medical Research Fund of Guangdong Province No. A2017248
Received  2018-05-31
Accepted  2018-09-29
DOI: 10.12015/issn.1674-8034.2019.02.014
Cite this article as: Bai ZQ, Shi J, Duan XH, et al. Prediction of lymph vascular space invasion in cervical squamous cell carcinoma by using volumetric dynamic contrast-enhanced MRI. Chin J Magn Reson Imaging, 2019, 10(2): 145-149. DOI:10.12015/issn.1674-8034.2019.02.014.

[1]
Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011, 61(2): 69-90.
[2]
严鸣，张彦娜，何洁华，等．淋巴脉管间隙浸润对早期宫颈鳞癌预后的影响．癌症, 2010, 29(4): 468-474.
[3]
Bosse T, Peters EE, Creutzberg CL, et al. Substantial lymph-vascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer: A pooled analysis of PORTEC 1 and 2 trials. Eur J Cancer, 2015, 51(13): 1742-1750.
[4]
Benedef JI, Odicino F, Maisonneuve P, et al. Carcinoma of the cervix uteri．Int J Gynaecol Obstet, 2006, 95(Suppl 1): 43-103．
[5]
Xie X, Song K, Cui B, et al. A comparison of the prognosis between adenocarcinoma and squamous cell carcinoma in stage IB-IIA cervical cancer. Int J Clin Oncol, 2018, 23(3): 522-531.
[6]
宋亮，谢思遐，战军，等. 652例早期宫颈癌患者临床病理特征分析及选择低危患者条件探讨．实用妇产科杂志, 2016, 32(2): 126-129.
[7]
李瑜，汪希鹏．宫颈癌患者脉管内癌栓浸润与其他临床病理因素的相关性分析．国际妇产科学杂志, 2016, 43(1): 87-91.
[8]
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: cervical cancer, V.2. 2015. (2014-09-18)[2018-05-12]. http://www.nccn.org/professional/physician_gls/PDF/cervicalcancer.pdf.
[9]
Sedlis A, Bundy BN, Rotman MZ, et al. A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: a gynecologic oncology study group. Gynecol Oncol, 1999, 73(2): 177-183.
[10]
Lee YY, Choi CH, Kim CJ, et al. The prognostic significance of the SUVmax (maximum standardized uptake value for F-18 fluorodeoxyglucose) of the cervical tumor in PET imaging for early cervical cancer: Preliminary results. Gynecol Oncol, 2009, 115(1): 65-68.
[11]
Koh TS, Bisdas S, Koh DM, et al. Fundamentals of tracer kinetics for dynamic contrast-enhanced MRI. J Magn Reson Imaging, 2011, 34(6): 1262-1276.
[12]
Walker-Samuel S, Leach MO, Collins DJ. Evaluation of response to treatment using DCE- MRI: the relationship between initial area under the gadolinium curve (IAUGC) and quantitative pharmacokinetic analysis. Phys Med Biol, 2006, 51(14): 3593-3602.
[13]
Thomassin-Naggara I, Balvay D, Aubert E, et al. Quantitative dynamic contrast-enhanced MR imaging analysis of complex adnexal masses: a preliminary study. Eur Radiol, 2012, 22(4): 738-745.
[14]
Li SP, Makris A, Beresford MJ, et al. Use of dynamic contrast-enhanced MR imaging to predict survival in patients with primary breast cancer undergoing neoadjuvant chemotherapy. Radiology, 2011, 260(1): 68-78.
[15]
O'Connor JP, Jackson A, Parker GJ, et al. DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. Br J Cancer, 2007, 96(2): 189-195.
[16]
叶裕丰，陈秋梅，向之明，等．磁共振灌注加权成像在宫颈癌表现特点的研究．磁共振成像, 2015, 6(4): 299-303.

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