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• Clinical Article •
Functional magnetic resonance imaging study on the effects of craving task on large-scale brain networks in heroin addicts
SHI Hong  CHEN Jiajie  WANG Fan  LIU Wei  LIU Jierong  XUE Jiuhua  WEI Xuan  LI Wei  ZHU Jia  LI Qiang  WANG Wei 

Cite this article as: Shi H, Chen JJ, Wang F, et al. Functional magnetic resonance imaging study on the effects of craving task on large-scale brain networks in heroin addicts. Chin J Magn Reson Imaging, 2019, 10(3): 161-168. DOI:10.12015/issn.1674-8034.2019.03.001.


[Abstract] Objective: To investigate the changes of subjective craving and characteristics of large-scale brain networks in heroin addicts during the drug cues task.Materials and Methods: Twenty-one heroin addicts and 33 healthy subjects matched by age, sex and education level were included in this study. Analysis of imaging and behavioral difference were carried out with Matlab, SPM8, DPABI and SPSS 20.0 software. The templates of task-negative network and task positive network were obtained from the resting state functional magnetic resonance data, and the differences in drug cue induced brain response within these networks were analyzed, and then the correlation analysis with psychological behavior was performed.Results: The craving score of heroin addicts after stimulation of drug cues was significantly higher than that of before the task (t=1.19, P=0.00), but no significant difference was found in normal control group (t=0.031, P=0.75). Compared with the normal group, the heroin addicts showed higher activation of task negative network (default mode network) and task positive network (salient network, executive control network, higher vision network, visuospatial network, basal ganlia) (P<0.05, AphaSim corrected). However, the response of primary visual network in task-positive network was lower in heroin addiction group relative to normal control group (P<0.05, AphaSim corrected). Controlling the head movement factor, the activation of basal nuclei in heroin addicts was positively correlated with the craving score after drug cue exposure (r=0.56, P=0.01).Conclusions: The large-scale brain networks of heroin addicts is commonly abnormal when exposed to drug related cues.
[Keywords] heroin dependence；craving；neural pathways；magnetic resonance imaging

SHI Hong Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

CHEN Jiajie Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

WANG Fan Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

LIU Wei Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

LIU Jierong Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

XUE Jiuhua Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

WEI Xuan Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

LI Wei Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

ZHU Jia Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

LI Qiang Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

WANG Wei* Radiology Department of Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China

*Correspondence to: Wang W, E-mail: tdwangw@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81671661, 81371532
Received  2018-08-01
Accepted  2018-11-03
DOI: 10.12015/issn.1674-8034.2019.03.001
Cite this article as: Shi H, Chen JJ, Wang F, et al. Functional magnetic resonance imaging study on the effects of craving task on large-scale brain networks in heroin addicts. Chin J Magn Reson Imaging, 2019, 10(3): 161-168. DOI:10.12015/issn.1674-8034.2019.03.001.

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