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• Clinical Article •
Effects of chemotherapy on brain activity in resting state and cognitive function in breast cancer patients
LIU Wei  SONG Chen  ZHANG Xiyou  LIU Yajie  SHA Lin  QIN Dongxue  YANG Chao  WU Jianlin 

Cite this article as: Liu W, Song C, Zhang XY, et al. Effects of chemotherapy on brain activity in resting state and cognitive function in breast cancer patients. Chin J Magn Reson Imaging, 2019, 10(3): 174-178. DOI:10.12015/issn.1674-8034.2019.03.003.


[Abstract] Objective: To evaluate the effects of chemotherapy on brain activity in resting state and cognitive function in breast cancer patients.Materials and Methods: Twenty-one breast cancer patients 3—4 weeks after surgery were recruited with mean age (50.14±13.12) years. Neuropsychological assessments and MRI data acquisition took place before(t1) and one months after chemotherapy(t2). Imaging data were obtained using a 3.0 T MRI scanner (verio, siemens, Germany), with a 8-channel receiver head coil. Rs-fMRI data were analyzed using DPARSF software by means of amplitude of low frequency fluctuation (ALFF). All statistics were performed with IBM SPSS 17.0. Paired-t test and pearson correlation analysis were used.Results: The MoCA scores of the breast cancer patients were not significantly changed one month after chemotherapy (t2) compared with the scores before (t1). The Stroop word test and Stroop interference test scores increased significantly at t2 compared with those at t1. The auditory verbal learning test 5 minutes delayed scores and the digital span backward test scores decreased significantly at t2 compared with those at t1.The ALLF values in the left inf-temporal gyri, right mid-temporal gyri, left mid-sup-temporal gyri and bilateral precuneus lobe increased significantly at t2 compared with those at t1.Conclusions: The executive, attention and memory functions declined after chemotherapy in breast cancer patients. The rs-fMRI showed increased activities in some DMN brain areas.
[Keywords] cognitive dysfunction；chemotherapy side effects；breast neoplasms；magnetic resonance imaging

LIU Wei Department of Radiology, the Second Clinical Hospital of Dalian Medical University, Dalian 116027, China

SONG Chen Department of Oncology, the Second Clinical Hospital of Dalian Medical University, Dalian 116027, China

ZHANG Xiyou Department of Radiology, the Second Clinical Hospital of Dalian Medical University, Dalian 116027, China

LIU Yajie Department of Radiology, the Second Clinical Hospital of Dalian Medical University, Dalian 116027, China

SHA Lin Department of Radiology, the Second Clinical Hospital of Dalian Medical University, Dalian 116027, China

QIN Dongxue Department of Radiology, the Second Clinical Hospital of Dalian Medical University, Dalian 116027, China

YANG Chao Department of Radiology, the Second Clinical Hospital of Dalian Medical University, Dalian 116027, China

WU Jianlin Department of Radiology, Affiliated Zhong Shan Hospital of Dalian University, Dalian 116001, China

*Correspondence to: Wu JL, E-mail: cjr.wujianlin@vip.163.com

Conflicts of interest   None.

Received  2018-10-18
Accepted  2019-01-22
DOI: 10.12015/issn.1674-8034.2019.03.003
Cite this article as: Liu W, Song C, Zhang XY, et al. Effects of chemotherapy on brain activity in resting state and cognitive function in breast cancer patients. Chin J Magn Reson Imaging, 2019, 10(3): 174-178. DOI:10.12015/issn.1674-8034.2019.03.003.

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