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• Clinical Article •
Disparity of brain regional homogeneity and the correlation research of its mental characteristics in methamphetamine and heroin use disorder patients
LIU Yan  LI Yongbin  DANG Shan  CHEN Jing  LI Qiang  ZHU Jia  XUE Jiuhua  LI Xuan  WANG Wei  LI Wei 

Cite this article as: Liu Y, Li YB, Dang S, et al. Disparity of brain regional homogeneity and the correlation research of its mental characteristics in methamphetamine and heroin use disorder patients. Chin J Magn Reson Imaging, 2019, 10(3): 179-184. DOI:10.12015/issn.1674-8034.2019.03.004.


[Abstract] Objective: To analyze the differences of brain local neuronal spontaneous activity of methamphetamine and heroin used disorder patients and its relevance to psychoethology. From the perspective of changes in brain activity caused by methamphetamine and heroin used disorder, to explore the underlying neural mechanism that leads to different mental conditions.Materials and Methods: Twenty-one male methamphetamine use disorder (MAUD), 21 demography matched heroin use disorder (HUD) and normal controls (NC) participants in this study. All MR imaging were acquired using an eight-channel head coil on a 3.0 T GE-Signa MRI scanner. Psychological situation was evaluated by the Self-reporting Inventory-90 (SCL-90). ReHo values were calculated and difference among three groups was analyzed by one-way analysis of variance (ANOVA). The relationship between brain regions and psychological symptoms was performed with total brain voxel-wise analytical method in MAUD group.Results: Two-two comparison between the three groups showed MAUD group showed higher levels of anxiety, hostility, stubborn and core psychotic compared with NC group. Additionally, those in the MAUD group had higher scores of hostility compared with HA group (P<0.05). There was no significant difference between HUD group and NC group. The ReHo values of multiple brain regions between the three groups were different and the brain regions were right cerebellum, right frontal middle gyrus, right putamen, right inferior temporal gyrus, left frontal super gyrus, left parietal inferior gyrus, left thalamus and left fusiform (P<0.001). Compared with the NC group, the MAUD group demonstrated significantly increased ReHo values in right frontal middle gyrus and right inferior temporal gyrus, significantly decreased in right cerebellum, left frontal super gyrus and right putamen. The HUD group demonstrated significantly increased ReHo values in right frontal middle gyrus, significantly decreased in left thalamus, left fusiform, right putamen and left parietal inferior gyrus. On same uptake drug time, compared with the HUD group, the MAUD group demonstrated significantly decreased brain regional homogeneity in resting-state of cerebellum and left frontal super gyrus, but increased in right frontal middle gyrus, right inferior temporal gyrus and left thalamus. In MAUD group, there is no correlation between total brain and psychological scale.Conclusions: Compared with HUD group, MAUD group was more damaging to the mood-regulation, auditory-related and memory-related brain regions. It may be the underlying pathological basis for the occurrence of its special mental symptoms.
[Keywords] methamphetamine；heroin dependence；mental disorders；magnetic resonance imaging

LIU Yan Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi'an 710038, China; Department of Radiology, Changqing Staff Hospital of Changqing Oilfield of Petro China, Xi'an 712000, China

LI Yongbin Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi'an 710038, China

DANG Shan Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi'an 710038, China

CHEN Jing Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi'an 710038, China

LI Qiang Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi'an 710038, China

ZHU Jia Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi'an 710038, China

XUE Jiuhua Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi'an 710038, China

LI Xuan Member team 4 brigade 13 squadrons, School of Basic Medicine, the Air Force Medical University, Xi'an 710032, China

WANG Wei Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi'an 710038, China

LI Wei* Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xi'an 710038, China

*Correspondence to: Li W, E-mail: tdliwei@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This paper is supported by the Natural Science Foundation of China No. 81771813, 81401393, 81671661
Received  2018-10-15
Accepted  2019-01-19
DOI: 10.12015/issn.1674-8034.2019.03.004
Cite this article as: Liu Y, Li YB, Dang S, et al. Disparity of brain regional homogeneity and the correlation research of its mental characteristics in methamphetamine and heroin use disorder patients. Chin J Magn Reson Imaging, 2019, 10(3): 179-184. DOI:10.12015/issn.1674-8034.2019.03.004.

[1]
Rogers SC, Pruitt CW, Crouch DJ, et al. Rapid urine drug screens: diphenhydramine and methadone cross-reactivity. Pediatr Emerg Care, 2010, 26(9): 665-666.
[2]
Barr AM, Panenka WJ, Macewan GW, et al. The need for speed: an update on methamphetamine addiction. J Psychiatry Neurosci, 2006, 31(5): 301-313.
[3]
Ares-Santos S, Granado N, Espadas I, et al. Methamphetamine causes degeneration of dopamine cell bodies and terminals of the nigrostriatal pathway evidenced by silver staining. Neuropsychopharmacology, 2014, 39(5): 1066-1080.
[4]
Panenka WJ, Procyshyn RM, Lecomte T, et al. Methamphetamine use: a comprehensive review of molecular, preclinical and clinical findings. Drug alcohol depend, 2013, 129(3): 167-179.
[5]
Hajebi A, Amini H, Kashani L, et al. Twelve-month course and outcome of methamphetamine-induced psychosis compared with first episode primary psychotic disorders. Early Interv Psychiatry, 2016, 1-7.
[6]
Lappin JM, Sara GE, Farrell M. Methamphetamine-related psychosis: an opportunity for assertive intervention and prevention. Addiction, 2016, 112(6): 927-928.
[7]
Li Q, Li W, Wang H, et al. Predicting subsequent relapse by drug-related cue-induced brain activation in heroin addiction: an event-related functional magnetic resonance imaging study. Addict Biol, 2014, 20(5): 968-978.
[8]
Wang Y, Zhu J, Li Q, et al. Altered fronto-striatal and fronto-cerebellar circuits in heroin-dependent individuals: a resting-state FMRI study. PLoS One, 2013, 8 (3): 1-8.
[9]
Pandria N, Kovatsi L, Vivas AB, et al. Resting-state abnormalities in heroin-dependent individuals. Neuroscience, 2016, 37(8): 113-145.
[10]
Mulert C, Kirsch V, Pascual-Marqui R, et al. Long-range synchrony of gamma oscillation and auditory hallucination symptoms in schizophrenia. Int J Psychophysiol, 2011, 79(1): 55-63.
[11]
Melloni L, Molina C, Pena M, et al. Synchronization of neural activity across cortical areas correlates with conscious perception. J Neurosci, 2007, 27(11): 2858-2865.
[12]
Plaze M, Bartres-Faz D, Martinot JL, et al. Left superior temporal gyrus activation during sentence perception negatively correlates with auditory hallucination severity in schizophrenia patients. Schizophrenia Res, 2006, 87(1/3): 109-115.
[13]
陈诚，王慧玲，吴士豪，等．基于HeHo方法的精神分裂症幻听患者静息态fMRI的研究．精神疾病与精神卫生, 2013, 13(2): 150-153.
[14]
Nestor LJ, Ghahremani DG, Monterosso J, et al. Prefrontal hypoactivation during cognitive control in early abstinent methamphetamine-dependent subjects. Psychiatry Res, 2011, 194(3): 287-295.
[15]
Carbo-Gas M, Vazquez-Sanroman D, Aguirre-Manzo L, et al. Involving the cerebellum in cocaine-induced memory: pattern of cFos expression in mice trained to acquire conditioned preference for cocaine. Addict Bbiol, 2014, 19 (1): 61-76.
[16]
Middleton FA, Strick PL. Cerebellar projections to the prefrontal cortex of the primate. J Neurosci, 2001, 21(2): 700-712.
[17]
Tavano A, Grasso R, Gagliardi C, et al. Disorders of cognitive and affective development in cerebellar malformations. Brain, 2007, 130(pt 10): 2646-2660.
[18]
Rusch N, Spoletini I, Wilke M, et al. Prefrontal-thalamic-cerebellar gray matter networks and executive functioning in schizophrenia. Schizophr Res, 2007, 93(1-3): 79-89.
[19]
Schutter DJ, van Honk J. A frame work for targeting alternative brain regions with repetitive trancranial magnetic stimulation in the treatment of depression. Psychiatry Neurosci, 2005, 30(2): 91-97.
[20]
Wilke M, Bria P, Paola MD, et al. Prefrontal-thalamic-cerebella gray matter networks and executive functioning in schizophrenia. Schizophr Res, 2007, 93(1-3): 79-89.
[21]
Spanagel R. Alcohol addiction research: from animal models to clinics. Best Pract Res Clin Gastroenterol, 2003, 17 (4): 507-518.
[22]
Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology, 2010, 35(1): 217-238.
[23]
Das D, Cherbuin N, Anstey KJ, et al. Lifetime cigarette smoking is associated with striatal volume measures. Addict Biol, 2012, 17(4): 817-825.

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