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• Clinical Article •
Diagnostic value of MRI and diffusion tensor imaging in full-term neonates with hypoxic ischemic encephalopathy
HUANG Zhenhuan  ZHAN Zejuan  TU Xuezhao  HE Yonghong  LIN Qi  YANG Jian 

Cite this article as: Huang ZH, Zhan ZJ, Tu XZ, et al. Diagnostic value of MRI and diffusion tensor imaging in full-term neonates with hypoxic ischemic encephalopathy. Chin J Magn Reson Imaging, 2019, 10(3): 185-189. DOI:10.12015/issn.1674-8034.2019.03.005.


[Abstract] Objective: To discuss the value of the quantitative determination of FA value and ADC value in the brain injury assessment on full-term neonates with HIE.Materials and Methods: From December 2016 to December 2017, 41 full-term neonates with HIE in our hospital were examined by conventional MRI and DTI. Another 10 normal full-term neonates were taken as control group. ADC/FA values were calculated in bilateral posterior limb of internal capsule (PLIC), genu of corpus callosum (GCC), splenium of corpus callosum (SCC), frontal white matter (FWM), occipital white matter (OWM), central centrum semiovale (CCS) and lentiform nucleus (LN), and were compared between control group and HIE group. The correlation between FA values and NBNA scores were analyzed, and the diagnostic accuracy of HIE was evaluated.Results: On convention MRI, PLIC, basal ganglia and thalamus lesions were only seen in moderate/severe HIE (P<0.05). Except for GCC and SCC , there was no difference in the ADC value and FA value between the left and right sides of the same ROI (P>0.05). The ADC values of FWM in moderate HIE and severe HIE except LN and FA values of moderate/severe HIE except LN were lower than those of control group (P <0.01). The ADC values and FA values of each ROI in mild HIE were similar to those in the control group (P>0.05). There were significant differences in FA values in mild /moderate/severe HIE and ADC values in FWM, GCC, OWM and SCC between mild and moderate and severe groups (P<0.05).Conclusions: The diagnostic veracity of FA value is superior to ADC value and conventional MRI in HIE. A significant positive correlation is found between FA value in PLIC and NBNA scores.
[Keywords] hypoxia-ischemia, brain；infant, newborn；magnetic resonance imaging

HUANG Zhenhuan Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

ZHAN Zejuan Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

TU Xuezhao Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

HE Yonghong Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

LIN Qi* Department of Radiology, the First Hospital of Longyan of Fujian Medical University, Longyan 364000, China

YANG Jian* Department of Radiology, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi’an 710061, China

*Correspondence to: Lin Q, E-mail: 2624403530@qq.com Yang J, E-mail: yj1118@mail.xjtu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Key Research and Development Program of China No. 2016YFC0100300 Key Clinical Specialty Discipline Construction Program of Fujian No. Fujian-Wei Medical Policy Letter 2018-145
Received  2018-10-03
Accepted  2019-01-18
DOI: 10.12015/issn.1674-8034.2019.03.005
Cite this article as: Huang ZH, Zhan ZJ, Tu XZ, et al. Diagnostic value of MRI and diffusion tensor imaging in full-term neonates with hypoxic ischemic encephalopathy. Chin J Magn Reson Imaging, 2019, 10(3): 185-189. DOI:10.12015/issn.1674-8034.2019.03.005.

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