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• Clinical Article •
Value of BOLD-MRI for the evaluation of short-term chemoradiotherapy efficacy in nasopharyngeal carcinoma
ZHANG Peixian  YU Shengnan  DING Jiule  XING Wei 

Cite this article as: Zhang PX, Yu SN, Ding QL, et al. Value of BOLD-MRI for the evaluation of short-term chemoradiotherapy efficacy in nasopharyngeal carcinoma. Chin J Magn Reson Imaging, 2019, 10(3): 190-194. DOI:10.12015/issn.1674-8034.2019.03.006.


[Abstract] Objective: To investigate the feasibility of blood oxygenation level-dependent MRI (BOLD-MRI) for evaluating short-term therapeutic effect of chemoradiotherapy in nasopharyngeal carcinoma (NPC).Materials and Methods: Forty-one cases with NPC confirmed by pathological biopsy exposed to the chemoradiotherapy being the induction chemotherapy (IC) followed by the concurrent chemoradiotherapy (CCRT) and adjuvant chemotherapy (AC) therapy. The conventional MRI was performed pre-IC and after CCRT + AC. They were used to measure the maximal length of the primary and metastatic tumors, and the diameter of the pathological lymph node, and then the regression rate of lesions was calculated for each patient. BOLD was performed pre- and post- IC, then the corresponding T2* value of tumor was measured (T2*baseline and T2*IC), respectively. According to the response evaluation criteria in solid tumors (Version 1.1), the patients were divided into the complete response (CR group) and not (non-CR) groups. The T stage, T2*baseline, and T2*IC were compared between the CR and non-CR groups. The correlation of the regression rate of tumor with the T stage, T2*baseline, and T2*IC was tested, respectively. The receiver operating characteristic curve (ROC) was used to compare the capacity of T stage, T2*baseline, and T2*IC in predicting complete response to the chemoradiotherapy for the cases with NPC.Results: T stage, T2*baseline, and T2*IC were statistically different between CR and non-CR groups (P<0.05), and they showed a linear correlation with the regression rate of tumor (r=-0.481, 0.748, and 0.617, all P<0.05). For predicting the complete response of the cases with NPC post-chemoradiotherapy, the area under ROC was 0.778, 0.903, and 0.763 for T stage, T2*baseline, and T2*IC, respectively (all P<0.05). T2*baseline was the best one that can predict the complete response for the cases with NPC while it is larger than 37.5 ms (P<0.05).Conclusions: The BOLD- based T2*baseline can predict the short-term chemoradiotherapy efficacy in NPC and can be used as a useful supplement to the conventional T stage.
[Keywords] nasopharyngeal neoplasms；magnetic resonance imaging；chemoradiotherapy

ZHANG Peixian Department of Radiology, the Third Affiliated Hospital of Soochow University, Changzhou 213003, China; Department of Radiology, Community Healthcare Center of Zouqu Town, Zhonglou District, Changzhou City, Changzhou 213144, China

YU Shengnan Department of Radiology, the Third Affiliated Hospital of Soochow University, Changzhou 213003, China

DING Jiule Department of Radiology, the Third Affiliated Hospital of Soochow University, Changzhou 213003, China

XING Wei* Department of Radiology, the Third Affiliated Hospital of Soochow University, Changzhou 213003, China

*Correspondence to: Xing W, E-mail: suzhxingwei@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  Project of Health Commission of Changzhou No. ZD201509 Applied and Basic Research Program of Science and Technology Bureau of Changzhou No. CJ20160038
Received  2018-09-20
Accepted  2018-11-20
DOI: 10.12015/issn.1674-8034.2019.03.006
Cite this article as: Zhang PX, Yu SN, Ding QL, et al. Value of BOLD-MRI for the evaluation of short-term chemoradiotherapy efficacy in nasopharyngeal carcinoma. Chin J Magn Reson Imaging, 2019, 10(3): 190-194. DOI:10.12015/issn.1674-8034.2019.03.006.

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