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• Clinical Article •
Application of 3.0 T whole body diffusion-weighted imaging for the evaluation of tumor response to induction chemotherapy in patients with multiple myeloma
ZHENG Menglong  WENG Chunjiao  LI Wenjuan  YAO Ziyun  XIE Daohai 

Cite this article as: Zheng ML, Weng CJ, Li WJ, et al. Application of 3.0 T whole body diffusion-weighted imaging for the evaluation of tumor response to induction chemotherapy in patients with multiple myeloma. Chin J Magn Reson Imaging, 2019, 10(3): 201-205. DOI:10.12015/issn.1674-8034.2019.03.008.


[Abstract] Objective: To investigate the feasibility of whole body diffusion-weighted imaging (WB-DWI) for the evaluation of response to induction chemotherapy in multiple myeloma (MM) patients.Materials and Methods: Fifty-four cases of MM patients (confirmed by pathology and hematologic laboratory analysis) were enrolled in this study between April 2016 and June 2018 at the First Affiliated Hospital of Soochow University, all of them underwent WB-DWI before and after induction chemotherapy. Quantitative ADC estimates were measured at the site of the lesions before and after chemotherapy. MM patients were divided into deep (complete response or very good partial response) and non-deep responders (partial response, minimal response, stable disease, or progressive disease) on the basis of M-proteins and light chains (serum and urine), and plasma cells from bone marrow biopsy measured at the time of diagnosis and at the end of induction treatment. And the percent variations in ADC were calculated and compared between deep responders and non-deep responders.Results: Among 54 cases, 35 patients were classified as deep-responders and 19 as non-deep responders. The ADC changes from baseline of deep responders were significantly higher than non-deep responders (0.68±0.39 vs 0.24±0.17×10-3 mm2/s, P<0.01). The ADC percent variations from baseline were significantly higher in deep responders compared to those in non-deep responders at the end of induction chemotherapy (101.63% vs 39.32%, P<0.01). The cut-off value of ADC percent variations for the diagnosis of deep response was 58.42%, the sensitivity and specificity was 91.4%, 89.5%, and the area under the ROC curve was 0.929.Conclusions: ADC change from WB-DWI MRI in MM patients who achieved deep response at the end of induction chemotherapy were significantly higher than those in patients who did not,which demonstrated that WB-DWI was a feasible diagnostic tool for the evaluation of response to induction chemotherapy in MM patients by quantifying ADC estimates before and after the treatment and could provide complementary information useful in monitoring therapy response.
[Keywords] multiple myeloma；magnetic resonance imaging；whole body imaging

ZHENG Menglong Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China

WENG Chunjiao Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China

LI Wenjuan Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China

YAO Ziyun Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China

XIE Daohai* Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China

*Correspondence to: Xie DH, E-mail: sdfyylxj@163.com

Conflicts of interest   None.

Received  2018-08-02
Accepted  2018-11-20
DOI: 10.12015/issn.1674-8034.2019.03.008
Cite this article as: Zheng ML, Weng CJ, Li WJ, et al. Application of 3.0 T whole body diffusion-weighted imaging for the evaluation of tumor response to induction chemotherapy in patients with multiple myeloma. Chin J Magn Reson Imaging, 2019, 10(3): 201-205. DOI:10.12015/issn.1674-8034.2019.03.008.

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