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• Clinical Article •
Modulation of catechol-O-methyltransferase Val158Met polymorphism on topological reorganization of white-matter networks in attention-deficit/hyperactivity disorder children
TIAN Tian  WANG Jian  ZHANG Guiling  LI Jia 

Cite this article as: Tian T, Wang J, Zhang GL, et al. Modulation of catechol-o-methyltransferase Val158Met polymorphism on topological reorganization of white-matter networks in attention-deficit/hyperactivity disorder children. Chin J Magn Reson Imaging, 2019, 10(4): 241-248. DOI:10.12015/issn.1674-8034.2019.04.001.


[Abstract] Objective: Attention-deficit/hyperactivity disorder (ADHD) children showed the redistribution of structural connectivity involving large-scale brain systems beyond the prefrontal-striatal model. The dopamine system has been associated with symptoms of ADHD, and is important for pharmacologic treatments. The current study aims to discuss that how dopamine impact neural circuitry underlying behavior pathways occurs in ADHD.Materials and Methods: We used diffusion tensor imaging and deterministic tractography to construct individual white matter structural networks in 40 patients and 40 age-matched healthy control participants. The automated anatomic labeling template was used to parcel the brain into 90 regions of interest to define the network nodes for each subject. The number of connected fibers between each pairs of nodes was calculated and defined as the edge weight between nodes. Catechol-O-methyltransferase (COMT) rs4680 genotyping was performed. All network analyses were performed by using in-house software Gretna. Graph theory approaches were used to investigate the topologic alterations in the structural brain networks between groups and their interaction. We used a network based statistic (NBS) approach to localize specific pairs of regions in which structural connectivity were altered. Finally, the connection strength of linking between hub nodes to hub nodes, hub nodes to nonhub nodes, and nonhub nodes to nonhub nodes were calculated and analyzed between groups.Results: We found significant reorganization of white matter structural networks in ADHD Met allele carriers, manifested as increased nodal degree, nodal efficiency, fronto-striatal circuitry, parietal-cingulum-motor circuitry, feeder and local connections.Conclusions: Those diffuse white matter alterations were not only implicated in fronto-striatal networks mediating executive functions but were also involving in sensorimotor network, frontal, cingulum, and parietal areas during perception-motor, higher order cognitive, attention control and processing. Together, these genetic-based findings highlight large-scale brain systems reorganization in ADHD, might also have important implications on the clinical pharmacologic treatments and development of pharmacogenomics.
[Keywords] attention-deficit/hyperactivity disorder；catechol-O-methyltransferase；dopamine；graph theory approach；diffusion tensor imaging；white matter

TIAN Tian* Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

WANG Jian Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

ZHANG Guiling Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

LI Jia Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

*Correspondence to: Tian T, E-mail: tongjitiantian@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No.81601475
Received  2018-10-15
Accepted  2018-12-19
DOI: 10.12015/issn.1674-8034.2019.04.001
Cite this article as: Tian T, Wang J, Zhang GL, et al. Modulation of catechol-o-methyltransferase Val158Met polymorphism on topological reorganization of white-matter networks in attention-deficit/hyperactivity disorder children. Chin J Magn Reson Imaging, 2019, 10(4): 241-248. DOI:10.12015/issn.1674-8034.2019.04.001.

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