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• Clinical Article •
Application of T2-matrix sequence in the diagnosis of acute lower extremity deep vein thrombosis
PENG Ruchen  DU Xiangying 

Cite this article as: Peng RC, Du XY. Application of T2-matrix sequence in the diagnosis of acute lower extremity deep vein thrombosis. Chin J Magn Reson Imaging, 2019, 10(4): 249-253. DOI:10.12015/issn.1674-8034.2019.04.002.


[Abstract] Objective: To investigate the value of T2 weighted 3D fast spin echo imaging with modulated refocusing flip angles (T2-MATRIX) in the diagnosis of acute lower extremity deep vein thrombosis (LEDVT), and to provide a new imaging method for the early and accurate diagnosis and treatment of LEDVT.Materials and Methods: Twenty-one patients with acute LEDVT were prospectively recruited. T2-MATRIX sequence was performed within 14 days after the symptom onset. Two radiologists performed double-blind interpretation of T2-MATRIX and magnetization preliminary gradient echo sequence (MPRAGE) images on vascular segment level. Two sequences were compared on thrombus length, thrombus area and thrombus signal intensity. MPRAGE and ultrasound were used as the reference to calculate the diagnostic accuracy of T2-MATRIX sequence for the detection of thrombus.Results: A total of 147 vascular segments were detected in 21 patients with acute LEDVT, and thrombi were detected in 67 of these segments. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of detection of LEDVT in T2-MATRIX at the level of vascular segments were 94.03%, 98.77%, 98.41%, 95.24% and 96.60%, respectively. Intraclass correlation coefficient and bland altman analysis showed that the T2-MATRIX and MPRAGE sequences were highly consistent in the measurement of thrombosis length (P≤0.05), thrombosis area (P≤0.05) and vascular diameter (P≤0.05), with the difference within the consistency boundary accounting for 98.51%, 97.1% and 100%, respectively.Conclusions: T2-MATRIX sequence has a high diagnostic accuracy in the diagnosis of acute LEDVT. Furthermore, surrounding soft tissue edema can also be depicted on the same sequence. It has great potential to become a new imaging method in clinical practice.
[Keywords] magnetic resonance imaging；black blood thrombosis imaging；lower extremity deep vein thrombosis

PENG Ruchen Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

DU Xiangying* Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

*Correspondence to: Du XY, E-mail: duxying_xw@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Beijing Science & Technology Commission in Tongzhou District No. KJ2018CX009-03
Received  2019-03-12
Accepted  2019-04-02
DOI: 10.12015/issn.1674-8034.2019.04.002
Cite this article as: Peng RC, Du XY. Application of T2-matrix sequence in the diagnosis of acute lower extremity deep vein thrombosis. Chin J Magn Reson Imaging, 2019, 10(4): 249-253. DOI:10.12015/issn.1674-8034.2019.04.002.

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