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• Clinical Article •
Effect of PTCD combined with albendazole on liver function and marginal ADC value in patients with end-stage hepatic alveolar echinococcosis
WANG Qiang  KANG Yingli  WANG Hu  LI Weixia  FAN Haining  BAO Haihua 

Cite this article as: Wang Q, Kang YL, Wang H, et al. Effect of PTCD combined with albendazole on liver function and marginal ADC value in patients with end-stage hepatic alveolar echinococcosis. Chin J Magn Reson Imaging, 2019, 10(4): 254-257. DOI:10.12015/issn.1674-8034.2019.04.003.


[Abstract] Objective: To treat patients with end-stage hepatic alveolar echinococcosis (HAE) jaundice by percutaneous transhepatic cholangial drainage (PTCD) combined with albendazole. The liver function index and the ADC value of the marginal zone were measured.Materials and Methods: Retrospective analysis of 40 cases of patients with obstructive jaundice of end-stage HAE diagnosed in the Department of Hepatobiliary and Pancreatic Surgery in our hospital from 2015 to 2017. The liver function indexes were compared before and after PTCD combined with drug treatment, and the ADC value of the marginal zone were also compared.Results: There were significant differences in ALT, TBIL, DBIL and IBIL between before and after treatment 3, 7, 10 days (P<0.05). There was no difference on the ADC value of the marginal zone around the lesion between before and after treatment 3 months (P>0.05), but there was a statistical difference between before and after treatment 6, 10 months (P<0.05). There was no difference on the ADC value between 6 months and the 10 months after treatment.Conclusions: In patients of obstructive jaundice with end-stage HAE, the liver function index decreased after PTCD and albendazole treatment, and after 6 months the activity of the marginal zone around the lesion tends to be stable.
[Keywords] hepatic alveolar echinococcosis；liver function；percutaneous transhepatic cholangial drainage；albendazole；apparent diffusion coefficient；magnetic resonance imaging

WANG Qiang# Medical College of Qinghai University, Xining 810001, China; Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Qinghai University, Xining 810001, China

KANG Yingli# Medical College of Qinghai University, Xining 810001, China; Image Center, Affiliated Hospital of Qinghai University, Xining 810001, China

WANG Hu Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Qinghai University, Xining 810001, China; Qinghai Province Health & Family Planning Commission, Xining 810001, China

LI Weixia Medical College of Qinghai University, Xining 810001, China; Image Center, Affiliated Hospital of Qinghai University, Xining 810001, China

FAN Haining* Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Qinghai University, Xining 810001, China; Qinghai Province Key Laboratory of Hydatid Disease Researsh, Xining 810001, China

BAO Haihua* Image Center, Affiliated Hospital of Qinghai University, Xining 810001, China

#: Co-first author

*Correspondence to: Fan HN, E-mail: fanhaining@medmail.com.cn; Bao HH, E-mail: baohe len2@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Special Project of National Key R&D Program of China "Precision Medical Research" No. 2017YFC0909900 Health Planning Commission's Guiding Project of Qinghai No. 2016-wjtg-04 Key Experimental Construction Project of Qinghai No. 2017-ZJ-Y32
Received  2018-10-12
Accepted  2018-12-12
DOI: 10.12015/issn.1674-8034.2019.04.003
Cite this article as: Wang Q, Kang YL, Wang H, et al. Effect of PTCD combined with albendazole on liver function and marginal ADC value in patients with end-stage hepatic alveolar echinococcosis. Chin J Magn Reson Imaging, 2019, 10(4): 254-257. DOI:10.12015/issn.1674-8034.2019.04.003.

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