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• Clinical Article •
The value of different diffusion models in the depth of myometrial invasion of stage I endometrial cancer
YIN Xi  WU Hui  GAO Yang  QIAO Pengfei  NIU Guangming 

Cite this article as: Yin X, Wu H, Gao Y, et al. The value of different diffusion models in the depth of myometrial invasion of stage I endometrial cancer. Chin J Magn Reson Imaging, 2019, 10(4): 258-262. DOI:10.12015/issn.1674-8034.2019.04.004.


[Abstract] Objective: To evaluate the value of monoexponential, biexponential, and stretched exponential diffusion-weighted imaging models in diagnosing the depth of myometrial invasion of stage Ⅰ endometrial cancer.Materials and Methods: 53 cases of stage Ⅰ endometrial cancer were collected, and conventional MRI and multi-b value DWI scan were performed. The apparent diffusion coefficient (ADC), true diffusion coefficient (D) and pseudo-diffusion coefficient (D*) were measured on the pseudo-color map of each parameter, perfusion fraction (f), distribution diffusion coefficient (DDC), water diffusion heterogeneity index (α) value. According to the pathological results after total hysterectomy, it was divided into stage Ⅰa and stage Ⅰb. Differences between the two groups were compared using two independent sample t-tests. The receiver operating characteristic (ROC) curve was plotted to evaluate the efficacy of each parameter in diagnosing the depth of myometrial invasion of stage Ⅰ endometrial cancer.Results: The values of D, f, DDC and ADC in Ⅰb phase were less than Ia, and the differences were statistically significant (P<0.05). The D* value in Ⅰb phase was greater than that in Ia, the difference was not statistically significant (P>0.05), Ⅰb phase the α value was less than stage Ⅰa, and the difference was not statistically significant (P>0.05). The area under the curve (AUC) of D, f, DDC, and ADC values for the diagnosis of myometrial invasion of stage Ⅰ endometrial cancer were 0.867, 0.762, 0.794, and 0.774, respectively.Conclusions: The monoexponential model can help to diagnose the depth of myometrial invasion of stage Ⅰ endometrial cancer. The biexponential, and stretched exponential models are superior to the monoexponential model.
[Keywords] magnetic resonance imaging；endometrial neoplasms；muscle infiltration depth；apparent diffusion coefficient

YIN Xi Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000, China

WU Hui Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000, China

GAO Yang Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000, China

QIAO Pengfei Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000, China

NIU Guangming* Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000, China

*Correspondence to: Niu GM, E-mail: Cjr.niuguangming@vip.163.com

Conflicts of interest   None.

Received  2018-10-29
Accepted  2019-03-06
DOI: 10.12015/issn.1674-8034.2019.04.004
Cite this article as: Yin X, Wu H, Gao Y, et al. The value of different diffusion models in the depth of myometrial invasion of stage I endometrial cancer. Chin J Magn Reson Imaging, 2019, 10(4): 258-262. DOI:10.12015/issn.1674-8034.2019.04.004.

[1]
Sergio P. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet, 2009, 105(2): 103-104.
[2]
Dogan D, Inan N. Preoperative evaluation of myometrial invasion in endometrial carcinoma: diagnostic performance of 3 T MRI. Abdom Imaging, 2013, 38(2): 388-396.
[3]
邢金丽，冯峰.单、双指数模型DWI在子宫内膜癌分期中的对比研究.实用放射学杂志, 2018, 34(3): 401-404.
[4]
张琪，余小多，林蒙,等.体素内不相干运动扩散加权成像术前评估子宫内膜癌分级、肌层侵犯的价值.磁共振成像, 2018, 9(3): 214-220.
[5]
Bennett KM, Schmainda KM, Bennett RT, et al. Characterization of continuously distributed cortical water diffusion rates with a stretched-exponential model. Magn Reson Med, 2003, 50(4): 727-734.
[6]
Lin M, Yu XD, Chen Y, et al. Contribution of mono-exponential, bi-exponential and stretched exponential model-based diffusion-weighted MR imaging in the diagnosis and differentiation of uterine cervical carcinoma. Eur Radiol, 2017, 27(6): 2400-2410.
[7]
Husby JA, Salvesen ØO, Magnussen IJ, et al. Tumour apparent diffusion coefficient is associated with depth of myometrial invasion and is negatively correlated to tumour volume in endometrial carcinomas. Clin Radiol, 2015, 70(5): 487-494.
[8]
尹希，吴慧，高阳,等.不同扩散模型在子宫内膜癌诊断中的应用.磁共振成像, 2018, 9(7): 556-560.
[9]
Bai Y, Lin Y, Tian J, et al. Grading of gliomas by using monoexponential, biexponential, and stretched exponential diffusion-weighted MR imaging and diffusion kurtosis MR imaging. Radiology, 2016, 278(2): 496-504.
[10]
Liu X, Zhou L, Peng W, et al. Comparison of stretched-Exponential and monoexponential model diffusion-weighted imaging in prostate cancer and normal tissues. J Magn Reson Imaging, 2015, 42(4): 1078-1085.
[11]
Andreou A, Koh DM, Collins DJ, et al. Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases. Eur Radiol, 2013, 23(2): 428-434.
[12]
Christian F, Patric H, Philippe M, et al. Dependence of brain intravoxel incoherent motion perfusion parameters on the cardiac cycle. PLoS One, 2013, 8(8): e72856.
[13]
Haldorsen IS, Stefansson I, Grüner R, et al. Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas. Br J Cancer, 2014, 110(1): 107-114.
[14]
Kwee TC, Galbán CJ, Tsien C, et al. Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomas. J Magn Reson Imaging, 2010, 31(3): 531-537.
[15]
Jamalhanjani M, Quezada SA, Larkin J, et al. Translational implications of tumor heterogeneity. Clin Cancer Res, 2015, 21(6): 1258-1266.

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