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• Clinical Article •
Evaluation of microcirculation perfusion in high-risk necrotic femoral head by DCE-MRI
MA Weili  ZHAO Dewei  WANG Benjie  YANG Song  YANG Pei  CHANG Xiaodan 

Cite this article as: Ma WL, Zhao DW, Wang BJ, et al. Evaluation of microcirculation perfusion in high-risk necrotic femoral head by DCE-MRI. Chin J Magn Reson Imaging, 2019 10(4): 263-267. DOI:10.12015/issn.1674-8034.2019.04.005.


[Abstract] Objective: To evaluate the changes of femoral head microcirculation perfusion in high-risk population of femoral head necrosis and the heterogeneity of femoral head blood perfusion in the normal femoral head by DCE-MRI, providing imaging evidence for ultralearly femoral head necrosis.Materials and Methods: Dynamic contrast-enhanced MRI of the hip was performed in 50 adults (a total of 60 cases of femoral head) with 30 cases experimental group who was high-risk patients with osteonecrosis of the femoral head. Another 30 cases of were selected as normal control group. The region of interest (ROI) was selected in the weight-bearing area (anterosuperior), non-weight-bearing area (inferior) and the central area of the femoral head, and the percentage time-intensity curve (TIC) was drawn to read the maximum percentage of enhancement at first pass (fEmax), maximum percentage of enhancement at first pass (Emax), time to peak (TTP) and other related parameters. Comparison of perfusion parameters between different ROI of normal femoral head and corresponding regions of high-risk population of femoral head necrosis by independent sample t-test. Comparison of perfusion parameters between weight bearing areas, non-weight bearing areas and the center of femoral head using analysis of variance.Results: The Emax of ROI in weight-bearing area, non-weight bearing area of the control group was greater than that of high-risk group of femoral head necrosis (P<0.05). The TTP of ROI in non-load area, centre of high risk group was greater than that of the control group of femoral head necrosis (P<0.05). Another important finding was that the fEmax, Emax varied widely in the control group. fEmax and Emax were significantly greater for the weight-bearing area, the center area than for the non-weight bearing area (P<0.01). There was no significant difference in TTP between different ROI in the control group (P>0.05).Conclusions: The ROI of the patients with high risk of avascular necrosis which was decreased compared with the ROI in corresponding with the normal femoral head; areas with more mechanical load had more blood perfusion. In addition, the perfusion volume of femoral head in high risk population is smaller than that of healthy people. The perfusion time was longer than that of the normal femoral head, and there was blood stasis. Therefore, DCE-MRI can be used to guide clinical practice and prevent avascular necrosis of the femoral head at an early stage.
[Keywords] femoral head necrosis；magnetic resonance imaging；dynamic contrast enhanced；microcirculation；blood perfusion；high risk group

MA Weili Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China

ZHAO Dewei Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China

WANG Benjie Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China

YANG Song Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China

YANG Pei Department of Radiology, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China

CHANG Xiaodan* Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China

*Correspondence to: Chang XD, E-mail: 13384111832@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No.81672139
Received  2019-01-14
Accepted  2019-02-18
DOI: 10.12015/issn.1674-8034.2019.04.005
Cite this article as: Ma WL, Zhao DW, Wang BJ, et al. Evaluation of microcirculation perfusion in high-risk necrotic femoral head by DCE-MRI. Chin J Magn Reson Imaging, 2019 10(4): 263-267. DOI:10.12015/issn.1674-8034.2019.04.005.

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