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• Original Article •
Voxel-mirrored homotopic connectivity in adolescents with internet addiction: A resting-state functional magnetic resonance imaging study
LI Minming  LIAO Xiangpeng  ZHAO Zhiyong  FAN Mingxia  YAN Chonghuai 

Cite this article as: Li MM, Liao XP, Zhao ZY, et al. Voxel-mirrored homotopic connectivity in adolescents with internet addiction: A resting-state functional magnetic resonance imaging study. Chin J Magn Reson Imaging, 2019, 10(4): 268-273. DOI:10.12015/issn.1674-8034.2019.04.006.


[Abstract] Objective: Voxel-mirrored homotopic connectivity (VMHC) was used to study the functional connectivity of cerebral hemispheres in internet addiction(IA) of adolescents.Materials and Methods: Resting state functional magnetic resonance imaging data and structural image data of 18 IA adolescents and 18 matched normal controls were collected, to obtain functional connections based on VMHC. The differences in VMHC values between the groups, the relationship between the mean VMHC values of differential brain regions and weekly online time, and also the diagnostic significance of VMHC for IA were analyzed.Results: The VMHC value of Medial prefrontal lobe was significantly enhanced in IA group (IA group vs. control group: 0.45 vs. 0.29, P<0.001). The VMHC value was significantly positively correlated with the Internet time of the IA group (r=0.48, P=0.003). The ROC results showed that medial prefrontal lobe mean VMHC value had a certain diagnostic value for IA adolescents (AUC=0.86, Threshold=0.41, sensitivity=72%, specificity=94%).Conclusions: The enhanced VMHC value of medial prefrontal lobe suggests abnormal functional connection between the hemispheres of IA adolescents, and provides objective imaging evidence for IA diagnosis.
[Keywords] internet addiction；adolescent；functional magnetic resonance imaging；voxel-mirrored homotopic connectivity

LI Minming# Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Department of Children’s Health, Shanghai Center for Women and Children’s Health, Shanghai 200062, China

LIAO Xiangpeng# Department of Pediatrics, Shanghai Pudong Gongli Hospital, Shanghai 200135, China

ZHAO Zhiyong East China Normal University, Shanghai Key Laboratory of Magnetic Resonance, Shanghai 200333, China

FAN Mingxia East China Normal University, Shanghai Key Laboratory of Magnetic Resonance, Shanghai 200333, China

YAN Chonghuai* Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

#: Co-first author

*Correspondence to: Yan CH, E-mail: yanch@shkeylab-ceh.org

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No.30771814 Foundation of Shanghai Municipal Health Commission No.201840093
Received  2018-11-23
Accepted  2019-02-22
DOI: 10.12015/issn.1674-8034.2019.04.006
Cite this article as: Li MM, Liao XP, Zhao ZY, et al. Voxel-mirrored homotopic connectivity in adolescents with internet addiction: A resting-state functional magnetic resonance imaging study. Chin J Magn Reson Imaging, 2019, 10(4): 268-273. DOI:10.12015/issn.1674-8034.2019.04.006.

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