Share：
Share this content in WeChat
X
[Chinese][PDF]116888
• Original Article •
Voxel-mirrored homotopic connectivity in adolescents with internet addiction: A resting-state functional magnetic resonance imaging study
LI Minming  LIAO Xiangpeng  ZHAO Zhiyong  FAN Mingxia  YAN Chonghuai 

Cite this article as: Li MM, Liao XP, Zhao ZY, et al. Voxel-mirrored homotopic connectivity in adolescents with internet addiction: A resting-state functional magnetic resonance imaging study. Chin J Magn Reson Imaging, 2019, 10(4): 268-273. DOI:10.12015/issn.1674-8034.2019.04.006.


[Abstract] Objective: Voxel-mirrored homotopic connectivity (VMHC) was used to study the functional connectivity of cerebral hemispheres in internet addiction(IA) of adolescents.Materials and Methods: Resting state functional magnetic resonance imaging data and structural image data of 18 IA adolescents and 18 matched normal controls were collected, to obtain functional connections based on VMHC. The differences in VMHC values between the groups, the relationship between the mean VMHC values of differential brain regions and weekly online time, and also the diagnostic significance of VMHC for IA were analyzed.Results: The VMHC value of Medial prefrontal lobe was significantly enhanced in IA group (IA group vs. control group: 0.45 vs. 0.29, P<0.001). The VMHC value was significantly positively correlated with the Internet time of the IA group (r=0.48, P=0.003). The ROC results showed that medial prefrontal lobe mean VMHC value had a certain diagnostic value for IA adolescents (AUC=0.86, Threshold=0.41, sensitivity=72%, specificity=94%).Conclusions: The enhanced VMHC value of medial prefrontal lobe suggests abnormal functional connection between the hemispheres of IA adolescents, and provides objective imaging evidence for IA diagnosis.
[Keywords] internet addiction；adolescent；functional magnetic resonance imaging；voxel-mirrored homotopic connectivity

LI Minming# Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Department of Children’s Health, Shanghai Center for Women and Children’s Health, Shanghai 200062, China

LIAO Xiangpeng# Department of Pediatrics, Shanghai Pudong Gongli Hospital, Shanghai 200135, China

ZHAO Zhiyong East China Normal University, Shanghai Key Laboratory of Magnetic Resonance, Shanghai 200333, China

FAN Mingxia East China Normal University, Shanghai Key Laboratory of Magnetic Resonance, Shanghai 200333, China

YAN Chonghuai* Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

#: Co-first author

*Correspondence to: Yan CH, E-mail: yanch@shkeylab-ceh.org

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No.30771814 Foundation of Shanghai Municipal Health Commission No.201840093
Received  2018-11-23
Accepted  2019-02-22
DOI: 10.12015/issn.1674-8034.2019.04.006
Cite this article as: Li MM, Liao XP, Zhao ZY, et al. Voxel-mirrored homotopic connectivity in adolescents with internet addiction: A resting-state functional magnetic resonance imaging study. Chin J Magn Reson Imaging, 2019, 10(4): 268-273. DOI:10.12015/issn.1674-8034.2019.04.006.

[1]
中国青少年网络协会.中国青少年网瘾调查报告(2009).北京:中国青少年网络协会,中国传媒大学调查统计研究所, 2010.
[2]
邓应梅，赵琳，王怡,等.国际疾病分类icd-11的特点与新进展.中华医院管理杂志, 2018, 34(6): 462.
[3]
Lim KO, Wozniak JR, Mueller BA, et al. Brain macrostructural and microstructural abnormalities in cocaine dependence. Drug Alcohol Depend, 2008, 92(1): 164-172.
[4]
Salo R, Nordahl TE, Buonocore MH, et al. Cognitive control and white matter callosal microstructure in methamphetamine-dependent subjects: a diffusion tensor imaging study. Biol Psychiatry, 2009, 65(2): 122-128.
[5]
Michael D, De Bellis, Elizabeth Van Voorhees, et al. Diffusion tensor measures of the corpus callosum in adolescents with adolescent onset alcohol use disorders. Alcohol Clin Exp Res, 2008, 32(3): 395-404.
[6]
Greicius MD, Supekar K, Menon V, et al. Resting-state functional connectivity reflects structural connectivity in the default mode network. Cerebral Cortex, 2009,19(1): 72-78.
[7]
Damoiseaux JS, Greicius MD. Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity. Brain Struct Funct, 2009, 213(6): 525-533.
[8]
Honey CJ, Kötter R, Breakspear M, et al. Network structure of cerebral cortex shapes functional connectivity on multiple time scales. Proc Natl Acad Sci U S A, 2007, 104(24): 10240-10245.
[9]
Lin F, Zhou Y, Du Y, et al. Abnormal white matter integrity in adolescents with internet addiction disorder: a tract-based spatial statistics study. PLoS One, 2012, 7(1): e30253.
[10]
Biswal B, Yetkin FZ, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med, 1995, 34(4): 537-541.
[11]
Zuo XN, Kelly C, Di Martino A, et al. Growing together and growing apart: regional and sex differences in the lifespan developmental trajectories of functional homotopy. J Neurosci, 2010, 30(45): 15034-15043.
[12]
Stark DE, Margulies DS, Shehzad ZE, et al. Regional variation in interhemispheric coordination of intrinsic hemodynamic fluctuations. J Neurosci, 2008, 28(51): 13754-13764.
[13]
周福庆，龚洪翰，吴麟,等.肌萎缩侧索硬化症患者脑镜像同伦功能连接的MRI初步研究.中华放射学杂志, 2014, 48(5): 375-380.
[14]
Tang C, Zhao Z, Chen C, et al. Decreased functional connectivity of homotopic brain regions in chronic stroke patients: A resting state fMRI study. PLoS One, 2016, 11(4): e0152875.
[15]
Wei J, Wei S, Yang R, et al. Voxel-mirrored homotopic connectivity of resting-state functional magnetic resonance imaging in blepharospasm. Front Psychol, 2018, 9: 1620.
[16]
Zhao L, Wang Y, Jia Y, et al. Altered interhemispheric functional connectivity in remitted bipolar disorder: A resting state fMRI study. Sci Rep, 2017, 7(1): 4698.
[17]
Jiang K, Ding L, Li H, et al. Degree centrality and voxel-mirrored homotopic connectivity in children with nocturnal enuresis: A functional MRI study. Neurol India, 2018, 66(5): 1359-1364
[18]
文超，朱天民，代宇,等.网络成瘾脑机制的神经影像学研究进展.中国中西医结合影像学杂志, 2016, 14(3): 127-130.
[19]
Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network. Ann N Y Acad Sci, 2008, 1124(1): 1-38.
[20]
Wee CY, Zhao Z, Yap PT, et al. Disrupted brain functional network in internet addiction disorder: a resting-state functional magnetic resonance imaging study. PLoS One, 2014, 9(9): e107306.
[21]
Ding X, Lee SW. Cocaine addiction related reproducible brain regions of abnormal default-mode network functional connectivity: a group ICA study with different model orders. Neurosci Lett, 2013, 548: 110-114.
[22]
Tschernegg M, Crone JS, Eigenberger T, et al. Abnormalities of functional brain networks in pathological gambling: a graph-theoretical approach. Front Hum Neurosci, 2013, 7: 625.
[23]
Tanabe J, Nyberg E, Martin LF, et al. Nicotine effects on default mode network during resting state. Psychopharmacology, 2011, 216(2): 287-295.
[24]
Ma N, Liu Y, Fu XM, et al. Abnormal brain default-mode network functional connectivity in drug addicts. PLoS One, 2011, 6(1): e16560.
[25]
Chanraud S, Pitel AL, Pfefferbaum A, et al. Disruption of functional connectivity of the default-mode network in alcoholism. Cerebral Cortex, 2011, 21(10): 2272-2281.
[26]
Ding WN, Sun JH, Sun YW, et al. Trait impulsivity and impaired prefrontal impulse inhibition function in adolescents with internet gaming addiction revealed by a Go/No-Go fMRI study. Behav Brain Funct, 2014, 10(1): 20.
[27]
Feng Q, Chen X, Sun J, et al. Voxel-level comparison of arterial spin-labeled perfusion magnetic resonance imaging in adolescents with internet gaming addiction. Behav Brain Funct, 2013, 9(1): 33.
[28]
Zhang SS, Wu W, Liu ZP, et al. Altered regional homogeneity in experimentally induced low back pain: a resting-state fMRI study. J Neuroeng Rehabil, 2014, 11(1): 115.
[29]
Huang T, Zhao Z, Yan C, et al. Altered spontaneous activity in patients with persistent somatoform pain disorder revealed by regional homogeneity. PLoS One, 2016, 11(3): e0151360.
[30]
杜万萍，刘军，周顺科,等.基于ReHo方法的大学生网络成瘾静息功能磁共振成像研究.中国临床心理学杂志, 2012, 20(4): 474-476.
[31]
Hormes JM, Kearns B, Timko CA. Craving facebook? behavioral addiction to online social networking and its association with emotion regulation deficits. Addiction, 2014, 109(12): 2079-2088.
[32]
Casale S, Caplan SE, Fioravanti G. Positive metacognitions about internet use: the mediating role in the relationship between emotional dysregulation and problematic use. Addict Behav, 2016, 59: 84-88.
[33]
Parker JD, Taylor RN, Eastabrook JM, et al. Problem gambling in adolescence: Relationships with internet misuse, gaming abuse and emotional intelligence. Pers Individ Dif, 2008, 45(2): 174-180.

PREV Evaluation of microcirculation perfusion in high-risk necrotic femoral head by DCE-MRI
NEXT Neuroimaging of multinodular and vacuolating neuronal tumor
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn