Share：
Share this content in WeChat
X
[Chinese][PDF]179176
• Experience Exchanges •
Neuroimaging of multinodular and vacuolating neuronal tumor
YOU Hui  LI Mingli  FENG Feng 

Cite this article as: You H, Li ML, Feng F. Neuroimaging of multinodular and vacuolating neuronal tumor. Chin J Magn Reson Imaging, 2019, 10(4): 274-278. DOI:10.12015/issn.1674-8034.2019.04.007.


[Abstract] Objective: To summarize the clinical, pathologic and imaging characteristics of multinodular and vacuolating neuronal tumors (MVNT) and improve the knowledge about this disease.Materials and Methods: Relevant English literature was reviewed and features of the reported MVNT cases were summarized. Accordingly, the cases with typical imaging findings of MVNT in local database were searched and their clinical and imaging featuers were analyzed.Results: Until January 2018, there are 87 MVNT with sufficient data had been reported in English literature. Among them, 31 cases were histologically proved. The mean age at presentation was 41(6—71) years old. A female predominance was observed. The clinical presentation included seizures/suspected seizure (1 episode), headache and nonspecific symptoms. Histologically, the MVNT consisted of multinodular tissue, with varying degrees of matrix vacuolization which indicated a dysplastic early neuronal phenotype. The tumors were located principally within the deep cortical ribbon and superficial subcortical white matter. Imaging findings corresponded well with the histologic features. Typical imaging features consisted of a cluster of variably sized nodular lesions located in the subcortical ribbon and superficial subcortical white matter following the gyral contour. They appeared hyperintense on T2WI and FLAIR images, and typically do not enhance or cause mass effect. There are 12 cases of MVNT with typical features identified among about 100 thousand cases in our database.Conclusions: MVNT is a benign lesion with typical histologic and imaging features. With improving knowledge of the features, most of the MVNTs may be diagnosed with neuroimaging without the need of biopsy.
[Keywords] multinodular and vacuolating neuronal tumor；magnetic resonance imaging；imaging diagnosis

YOU Hui Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China

LI Mingli* Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China

FENG Feng Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China

*Correspondence to: Li ML, E-mail: limingli@pumch.cn

Conflicts of interest   None.

Received  2018-04-14
Accepted  2018-06-15
DOI: 10.12015/issn.1674-8034.2019.04.007
Cite this article as: You H, Li ML, Feng F. Neuroimaging of multinodular and vacuolating neuronal tumor. Chin J Magn Reson Imaging, 2019, 10(4): 274-278. DOI:10.12015/issn.1674-8034.2019.04.007.

[1]
Huse JT, Edgar M, Halliday J, et al. Multinodular and vacuolating neuronal tumors of the cerebrum: 10 cases of a distinctive seizure-associated lesion. Brain Pathol, 2013, 23(5): 515-524.
[2]
Bodi I, Curran O, Selway R, et al. Two cases of multinodular and vacuolating neuronal tumour. Acta Neuropathol Commun, 2014, 20(2): 7.
[3]
Fukushima S, Yoshida A, Narita Y, et al. Multinodular and vacuolating neuronal tumor of the cerebrum. Brain Tumor Pathol, 2015, 32(2): 131-136.
[4]
Nagaishi M, Yokoo H, Nobusawa S, et al. Localized overexpression of alpha-internexin within nodules in multinodular and vacuolating neuronal tumors. Neuropathology, 2015, 35(6): 561-568.
[5]
Yamaguchi M, Komori T, Nakata Y, et al. Multinodular and vacuolating neuronal tumor affecting amygdala and hippocampus: A quasi-tumor?. Pathol Int, 2016, 66(1): 34-41.
[6]
Cathcart SJ, Klug JR, Helvey JT, et al. Multinodular and vacuolating neuronal tumor: A rare seizure-associated entity. Am J Surg Pathol, 2017, 41(7): 1005-1010.
[7]
Nunes RH, Hsu CC, da Rocha AJ, et al. Multinodular and vacuolating neuronal tumor of the cerebrum: A new "leave me alone" lesion with a characteristic imaging pattern. AJNR Am J Neuroradiol, 2017, 38(10): 1899-1904.
[8]
Badat N, Savatovsky J, Charbonneau F, et al. Multinodular vacuolating and neuronal tumor of the cerebrum. Neurology, 2017, 89(3): 304-305.
[9]
Alsufayan R, Alcaide-Leon P, de Tilly LN, et al. Natural history of lesions with the MR imaging appearance of multinodular and vacuolating neuronal tumor. Neuroradiology, 2017, 59(9): 873-883.
[10]
Thom M, Liu J, Bongaarts A, et al. Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia?. Brain Pathol, 2018, 28(2): 155-171.
[11]
Monté AMC, D'Arco F, De Cocker LJL. Multinodular and vacuolating neuronal tumor in an adolescent with klinefelter syndrome. Neuroradiology, 2017, 59(12): 1187-1188.
[12]
Gonzalez-Quarante LH, Ruiz-Juretschke F, Sola Vendrell E, et al. Multinodular and vacuolating neuronal tumor of the cerebrum: A rare entity. New case and review of the literature. Neurocirugia (Astur), 2018, 29(1): 44-55.
[13]
Kapucu I, Jhaveri MD, Kocak M, et al. Multinodular and vacuolating neuronal tumor of the cerebrum: A benign nonaggressive cerebral lesion. Eur Neurol, 2018, 79(1-2): 74-75.
[14]
Rudie JD, Rauschecker AM, Nabavizadeh SA, et al. Neuroimaging of dilated perivascular spaces: From benign and pathologic causes to mimics. J Neuroimaging, 2018, 28(2): 139-149.
[15]
Lecler A, Chauvet D, Biassette HA, et al. Multiparametric imaging improves confidence in the diagnosis of multinodular and vacuolating neuronal tumor of the cerebrum. AJNR Am J Neuroradiol, 2018, 39(2): E32-E33.

PREV Voxel-mirrored homotopic connectivity in adolescents with internet addiction: A resting-state functional magnetic resonance imaging study
NEXT A case of primary gastrointestinal stromal tumor in the liver
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn