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Advances in late onset Alzheimer's disease susceptibility genes and their effects on brain structure and function
WANG Junxia  WU Sichu  ZHANG Xin  ZHANG Bing 

Cite this article as: Wang JX, Wu SC, Zhang X, et al. Advances in late onset Alzheimer's disease susceptibility genes and their effects on brain structure and function. Chin J Magn Reson Imaging, 2019, 10(4): 281-287. DOI:10.12015/issn.1674-8034.2019.04.009.


[Abstract] Alzheimer's disease (AD) is the most common type of dementia, which is characterized by progressive memory loss and cognitive decline. To date, APOE is the only known risk gene associated with distributed AD. With the development of genome-wide association studies and magnetic resonance imaging technology, more and more genes have been reported to be associated with AD, brain structure and function, such as Bridging integrator 1, Clusterin etc. However, the pathologic mechanism of these genes in AD is not clear. This paper reviews the action pathway of APOE and other genes and their effects on AD, brain structure and brain function.
[Keywords] alzheimer disease；genetic pathway；brain structure；brain function；magnetic resonance imaging

WANG Junxia Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China

WU Sichu Department of Radiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

ZHANG Xin Department of Radiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China

ZHANG Bing* Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China

*Corresponding to: Zhang B, E-mail: zhangbing_nanjing@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Science and Technology Plan Project Social Development Fund of Jiangsu Province No. BE2016605
Received  2018-06-25
Accepted  2018-07-27
DOI: 10.12015/issn.1674-8034.2019.04.009
Cite this article as: Wang JX, Wu SC, Zhang X, et al. Advances in late onset Alzheimer's disease susceptibility genes and their effects on brain structure and function. Chin J Magn Reson Imaging, 2019, 10(4): 281-287. DOI:10.12015/issn.1674-8034.2019.04.009.

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