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Magnetic resonance imaging for early diagnosis of neonatal bilirubin encephalopathy
CAO Jing  LIU Guangyao  LI Li  GAN Tiejun  ZHANG Jing 

Cite this article as: Cao J, Liu GY, Li L, et al. Magnetic resonance imaging for early diagnosis of neonatal bilirubin encephalopathy. Chin J Magn Reson Imaging, 2019, 10(4): 303-207. DOI:10.12015/issn.1674-8034.2019.04.013.


[Abstract] Bilirubin encephalopathy (BE) is one of the important causes of severe brain injury in newborns, resulting in severe neurological sequelae. Early accurate diagnosis of acute bilirubin encephalopathy can provide a basis for clinical treatment and help to improve prognosis. At present, it is generally believed that the high symmetry signal of bilateral globus pallidus in conventional, MRI T1WI sequence is characteristic of neonatal acute BE, but the presence of myelin in neonatal period affects signal interpretation, low specificity and high false positive rate. The use of advanced functional magnetic resonance imaging techniques can improve the diagnostic rate of BE, provide an objective basis for the early diagnosis of BE, shed new insights into pathogenesis of neurotoxic brain damage and changes the neural pathway pattern of neurotoxic brain damage caused by hyperbilirubin, such as diffusion-weighted imaging, magnetic resonance spectroscopy, diffusion tensor imaging, and diffusion kurtosis imaging. This article will review the current research progress of early diagnosis of acute bilirubin encephalopathy by magnetic resonance imaging.
[Keywords] bilirubin encephalopathy；nuclear jaundice；hyperbilirubinemia；neonatal；magnetic resonance imaging

CAO Jing Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730000, China

LIU Guangyao Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730000, China

LI Li Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730000, China

GAN Tiejun Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730000, China

ZHANG Jing* Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730000, China

*Corresponding to: Zhang J, E-mail: lztong2001@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Natural Science Foundation of Science and Technology Department of Gansu Province No.18JR3RA317
Received  2018-10-17
Accepted  2018-12-12
DOI: 10.12015/issn.1674-8034.2019.04.013
Cite this article as: Cao J, Liu GY, Li L, et al. Magnetic resonance imaging for early diagnosis of neonatal bilirubin encephalopathy. Chin J Magn Reson Imaging, 2019, 10(4): 303-207. DOI:10.12015/issn.1674-8034.2019.04.013.

[1]
Olusanya BO, Kaplan M. Neonatal hyperbilirubinaemia: a global perspective. Lancet Child Adolesc Health, 2018, 8(2): 610-620.
[2]
中华医学会儿科学会新生儿学组.中国新生儿胆红素脑病的多中心流行病学调查研究.中华儿科杂志, 2012, 50(5): 331-335.
[3]
蔡艳华，陈梅.新生儿急性胆红素脑病颅脑MRI特征改变的临床意义.中国实用医药, 2018, 13(18): 37-38.
[4]
Fujiwara R, Haag M, Schaeffeler E, et al. Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia. Hepatology, 2017, 67(4): 1-54.
[5]
Gazzin S, Berengeno AL, Strazielle N, et al. Modulation of Mrpl(ABCcl)and Pgn (ABcbl)by bilirubin at the bIood-CSF and blood-brain barries in the Gunn rat.PLoS One, 2011, 6(1): e16165.
[6]
Wisnowski JL, Panigrahy A, Painter MJ, et al. Magnetic resonance imaging of bilirubin encephalopathy: current limitations and future promise. Semin Perinatol, 2014, 38(7): 422-428.
[7]
Sahabettin Sarı, Alpaslan Yavuz, Aabdussamet Batur, et al. Brain magnetic resonance imaging and magnetic resonance spectroscopy findings of children with kernicteru. Pol J Radiol, 2015, 80(1): 72-80.
[8]
高军. 3.0 T磁共振成像在新生儿胆红素脑病早期诊断中的应用价值分析.中国继续医学教育, 2018, 10(2): 61-63.
[9]
Zhang L. Severe neonatal hyperbilirubinemia induces temporal and occipital lobe seizures. PloS One, 2018, 13(5): e0197113.
[10]
Ahlfors CE, Amin SB, Parker AE. Unbound bilirubin predicts abnormal automated auditory brain stem response in adiverse newborn population. J Perinatol, 2009, 29(4): 305-309.
[11]
Neknek GA, Woldemichael K, Moges A, et al. MRI of bilirubin encephalopathy (kernicterus): A case series of 4 patients from Sub- Saharan Africa, May 2017. Radiol Case Reports, 2018, 13(3): 676-679.
[12]
葛艳明，李耀武，董鹏,等.磁共振成像在新生儿高胆红素血症中的应用价值研究.临床放射学杂志, 2013, 32(11): 1630-1633.
[13]
吴武林，张平，娄明武,等. DWI及常规MR在新生儿高胆红素血症及胆红素脑病诊断中的应用.实用放射学杂志, 2011, 27(8): 1242-1244.
[14]
符式新，张凯钟，柏燕.胆红素脑病患儿的MRI、MRS的影像特点及其临床转归.中国CT和MRI杂志, 2018, 16(3): 11-13.
[15]
易明岗，姜忠强，赵建设,等.苍白球与壳核T1WI信号强度比值在新生儿急性胆红素脑病分级及预后中的价值.中华放射学杂志, 2017,51(3): 214-218.
[16]
孟小丽，张雷，王晓虎,等.新生儿重度高胆红素血症的MRI信号特征分析.磁共振成像, 2018, 9(10): 768-772.
[17]
Brites D. The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation. Frontiers in Pharmacology, 2012, 88(3): 88.
[18]
Stevenson D, Maisels MJ, Watchko J. Care of the Jaundiced Neonate Ebook. New York: McGraw-Hill, 2012.
[19]
Wang X, Wu W, Hou BL, et al. Studying neonatal bilirubin encephalopathy with conventional MRI, MRS, and DWI. Neuroradiology, 2008, 50(10): 885-893.
[20]
Cece H, Abuhandan M, Cakmak A, et al. Diffusion-weighted imaging of patients with neonatal bilirubin encephalopathy. Jpn J Radiol, 2013, 31(3): 179-185.
[21]
Watchko JF, Painter MJ, Panigrahy A. Quantitative ADC in bilirubin encephalopathy. Jpn J Radiol, 2013, 31(4): 299-300.
[22]
Wisnowski JL, Panigrahy A, Painter MJ, et al. Magnetic resonance imaging abnormalities in advanced acute bilirubin encephalopathy highlight dentato-thalamo-cortical pathways. J Pediatr, 2016, 174(6): 260-263.
[23]
Wu W, Zhang P, Wang X, et al. Usefulness of 1H-MRS in differentiating bilirubin encephalopathy from severe hyperbilirubinemia in neonates. J Magn Reson Imaging, 2013, 38(3): 634-640.
[24]
闫瑞芳.足月新生儿高胆红素血症的脑多模态磁共振成像研究.郑州:郑州大学, 2017.
[25]
Oakden WK, Moore AM, Blaser S, et al. 1H-MR spectroscopic characteristics of kernicterus: a possible metabolic signature. AJNR Am J Neuroradiol, 2005, 26(6): 1571-1574.
[26]
Barkovich AJ, Miller SP, Bartha A, et al. MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy. AJNR Am J Neuroradiol, 2006, 27(3): 533-547.
[27]
Yan R, Han D, Ren J, et al. Application values of conventional MRI combined with DTI in neonatal hyperbilirubinemia. Pediatr Neonatol, 2017, 59(2): 161-167.
[28]
Zhang CZ, Li Q, Wang P, et al. Demonstrating microstructural environment of the brain in neonatal bilirubin encephalopathy with diffusion kurtosis imaging. Iranian J Radiol, 2017, 14(2): e44126.

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