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Recent advances in application of Gd-EOB-DTPA MRI in the surveillance for early stage of hepatocarcinogenesis
E Tuya  OU Yanghan 

Cite this article as: E Tuya, OU Yanghan. Recent advances in application of Gd- EOB-DTPA MRI in the surveillance for early stage of hepatocarcinogenesis. Chin J Magn Reson Imaging, 2019, 10(4): 312-316. DOI:10.12015/issn.1674-8034.2019.04.015.


[Abstract] Hepatocellular carcinoma, based on liver cirrhosis, develops via the multistep process of hepatocarcinogenesis. Dysplastic nodule and early HCC, which are at the adjacent stages in the process, are in the high risk for transformation into advanced HCC, thus it is important for these nodules to be early detected and accurately diagnosed. Gd-EOB-DTPA is a hepatocyte specific magnetic resonance imaging contrast agent. It has demonstrated an increased ability of Gd-EOB-DTPA for the detection and higher accurate qualitative diagnosis rate of small liver lesions (<2 cm, especially<1 cm) due to its dual performance-extracellular and intracellular contrast agent performance. It benefits early detection of HCC and provides more treatment options with better effectiveness, consequently, prolongs the patient’s survival expectancy and improves the patient’s survival quality. The article aims to summarize, review and focus on the corresponding microscopic pathological and functional changes in the dynamic evolution process of dysplastic nodules and early hepatocellular carcinoma, which can be identified and observed by combining Gd-EOB-DTPA with other MRI sequences for the differential diagnosis and outcome evaluation of liver cirrhosis-associated nodules.
[Keywords] magnetic resonance imaging；Gd-EOB-DTPA；dysplastic nodule；liver neoplasms；liver cirrhosis

E Tuya Department of Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

OU Yanghan* Department of Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

*Corresponding to: Ou YH, E-mail: houybj@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81671677
Received  2018-11-02
Accepted  2019-01-30
DOI: 10.12015/issn.1674-8034.2019.04.015
Cite this article as: E Tuya, OU Yanghan. Recent advances in application of Gd- EOB-DTPA MRI in the surveillance for early stage of hepatocarcinogenesis. Chin J Magn Reson Imaging, 2019, 10(4): 312-316. DOI:10.12015/issn.1674-8034.2019.04.015.

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