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The progress of aquaporin magnetic resonance molecular imaging in tumors
XIAO Gang  HU Yuchuan  CUI Guangbin 

Cite this article as: Xiao G, Hu YC, Cui GB. The progress of aquaporin magnetic resonance molecular imaging in tumors. Chin J Magn Reson Imaging, 2019, 10(4): 317-320. DOI:10.12015/issn.1674-8034.2019.04.016.


[Abstract] Aquaporins (AQPs), an intrinsic protein that selectively transports water molecules on the cell membrane, is widely distributed in various tissues throughout the body. Their changes in physiological and pathological state are closely related to the occurrence and development of many diseases, especially the growth, infiltration and metastasis of malignant tumors. Early accurately detecting the distribution and expression level of AQPs in tumor cells can provide more information for preoperative diagnosis, staging and postoperative efficacy evaluation. In recent years, multi b-values diffusion weighted imaging (DWI) based on the theory of AQPs, which reflects the distribution and function of cell membrane AQPs through changes in apparent diffusion coefficient (ADC), has shown great development potential and open up a new field of magnetic resonance (MR) molecular imaging. In this article, we briefly outlined the basic structure, physiological functions, expression and significance of AQPs in tumors, and reviewed the basic principle of AQP-MR molecular imaging and its application in tumors.
[Keywords] aquaporin；diffusion weighted imaging；apparent diffusion coefficient；magnetic resonance imaging；tumor

XIAO Gang Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, the Military Medical University of PLA Airforce, Xi’an 710038, China

HU Yuchuan Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, the Military Medical University of PLA Airforce, Xi’an 710038, China

CUI Guangbin* Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, the Military Medical University of PLA Airforce, Xi’an 710038, China

*Corresponding to: Cui GB, E-mail: cuigbtd@fmmu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of Science and Technology Innovation Development Foundation of Tangdu Hospital No. 2017LCYJ004
Received  2018-09-30
Accepted  2018-12-12
DOI: 10.12015/issn.1674-8034.2019.04.016
Cite this article as: Xiao G, Hu YC, Cui GB. The progress of aquaporin magnetic resonance molecular imaging in tumors. Chin J Magn Reson Imaging, 2019, 10(4): 317-320. DOI:10.12015/issn.1674-8034.2019.04.016.

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