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• Clinical Article •
The diagnostic value of multi b-values diffusion weighted imaging in the genotypes of WHO grade Ⅱ—Ⅲ astrocytomas
DENG Xiaolin  ZHANG Hui  WANG Xiaochun  TAN Yan  QIN Jiangbo 

Cite this article as: Deng XL, Zhang H, Wang XC, et al. The diagnostic value of multi b-values diffusion weighted imaging in the genotypes of WHO grade Ⅱ—Ⅲ astrocytomas. Chin J Magn Reson Imaging, 2019, 10(5): 327-330. DOI:10.12015/issn.1674-8034.2019.05.002.


[Abstract] Objective: To investigate the value of multiple b-values diffusion weighted imaging (DWI) in predicting the genotype of isocitrate dehydrogenase1 (IDH) in WHO grade Ⅱ—Ⅲ astrocytomas.Materials and Methods: Patients' data of WHO grade Ⅱ—Ⅲ astrocytomas with IDH genetic information were collected. All routine magnetic resonance imaging (MRI) and multiple b-values DWI were performed before surgery. Measuring the parameters of the astrocytoma's parenchyma and the contralateral normal brain's parenchyma: aquaporines related diffusion coefficient (AQP-ADC), true diffusion coefficient (D), perfusion related diffusion coefficient (D*) and perfusion fraction (f). Then calculate the calibrated parameters (tumor parameters values divided by parameters values measured in the contralateral normal brain's parenchyma): relative AQP-ADC (rAQP-ADC), relative D (rD), relative D* (rD*), relative f (rf). A t-test of two samples was used to analyze the difference in parameters between different gene states, and the receiver operating characteristic (ROC) curve was plotted to calculate the threshold, sensitivity and specificity.Results: For astrocytomas, the rD value of IDH mutation group was higher than the IDH wild-type, while the D* value, rD* value and rf value of the mutation group were lower than the wild type, the difference was statistically significant (P< 0.05). The area under the ROC curve, the threshold, the sensitivity and the specificity of the rD were 0.706, 1.839, 64.71%, 80.00%. The D* were 0.814, 0.00267, 88.24%, 66.67%. The rD* were 0.759, 0.969, 58.82%, 93.33%. The rf were 0.710, 1.875, 88.24%, 53.33%.Conclusions: Multi b-values DWI has certain application value for diagnosis of IDH genotype in WHO grade Ⅱ—Ⅲ astrocytomas. The values of D* and rf are more sensitive to diagnose the genotypes of astrocytoma, while the value of rD* has higher specificity.
[Keywords] astrocytoma；brain neoplasms；magnetic resonance imaging；genotype

DENG Xiaolin Department of Medical Imaging, Shanxi Medical University, Taiyuan 030000, China

ZHANG Hui* Department of Radiology, the First Hospital of Shanxi Medical University, Taiyuan 030000, China

WANG Xiaochun Department of Radiology, the First Hospital of Shanxi Medical University, Taiyuan 030000, China

TAN Yan Department of Radiology, the First Hospital of Shanxi Medical University, Taiyuan 030000, China

QIN Jiangbo Department of Radiology, the First Hospital of Shanxi Medical University, Taiyuan 030000, China

*Correspondence to: Zhang H, E-mail: zhanghui_mr@163.com

Conflicts of interest   None.

Received  2019-02-10
Accepted  2019-04-20
DOI: 10.12015/issn.1674-8034.2019.05.002
Cite this article as: Deng XL, Zhang H, Wang XC, et al. The diagnostic value of multi b-values diffusion weighted imaging in the genotypes of WHO grade Ⅱ—Ⅲ astrocytomas. Chin J Magn Reson Imaging, 2019, 10(5): 327-330. DOI:10.12015/issn.1674-8034.2019.05.002.

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