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• Clinical Article •
The differences of DRD2TaqIA genotype on functional connectivity of insula in heroin addicts undergoing methadone maintenance treatment: a resting-state fMRI study
HU Feng  WANG Lei  SHI Hong  LI Xiaohuai  LI Wei  LI Qiang  WANG Wei  WANG Yarong 

Cite this article as: Hu F, Wang L, Shi H, et al. The differences of DRD2TaqIA genotype on functional connectivity of insula in heroin addicts undergoing methadone maintenance treatment: a resting-state fMRI study. Chin J Magn Reson Imaging, 2019, 10(5): 331-336. DOI:10.12015/issn.1674-8034.2019.05.003.


[Abstract] Objective: This study aimed to explore the differences and significance of whole brain functional connectivity (FC) seeding as insula between heroin addicts undergoing methadone maintenance treatment (MMT) with different DRD2TaqIA genetic variants by a functional connectivity method.Materials and Methods: Twenty-seven male MMT carrier A1 allele (A+ group) and 20 age, education, smoking matched homozygous A2 allele males MMT (A- group) participated in this study. Rest-state functional MRI was performed with 3.0 T scanner. The abstinent time was defined by the monthly structure interview and urine test in the subsequent 12 nomths after the MRI scan. The MRI data analysis was conducted by the toolbox DPABI. The whole brain FC seeding as bilateral insula was obtained in group A+ and group A-. Next, intergroup differences of the insula FC was calculated with two-sample t test. Moreover, the partial correlation between abstinent time after the MRI scan and the intensity of FC which is intergroup significantly different was analyzed.Results: Compared with A- group, A+ group showed reduced FC between the right insula and the bilateral dorsolateral prefrontal cortex, and the bilateral caudate nucleus (cluster size>5, FDR correction, P<0.001). In addition, FC intensity between the right insula and the right dorsolateral prefrontal cortex had a positive correlation with abstinent time (r=0.378, P=0.011. Bonferroni correction P<0.05).Conclusions: There were significant differences in insular functional connectivity feature between heroin addicts undergoing methadone maintenance treatment (MMT) with different DRD2TaqIA genetic variants. It might one of the important pathway that the insula regulation of inhibitory control function and reward neural circuit, through which DRD2TaqIA genotype influence on relapse behavior in MMT.
[Keywords] heroin dependence；methadone；genotype；brain；magnetic resonance imaging

HU Feng Department of Radiology, Tangdu Hospital, the Air Force Military University, Xi'an 710038, China

WANG Lei Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

SHI Hong Department of Radiology, Tangdu Hospital, the Air Force Military University, Xi'an 710038, China

LI Xiaohuai Department of Radiology, Tangdu Hospital, the Air Force Military University, Xi'an 710038, China

LI Wei Department of Radiology, Tangdu Hospital, the Air Force Military University, Xi'an 710038, China

LI Qiang Department of Radiology, Tangdu Hospital, the Air Force Military University, Xi'an 710038, China

WANG Wei Department of Radiology, Tangdu Hospital, the Air Force Military University, Xi'an 710038, China

WANG Yarong* Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

*Correspondence to: Wang YR, E-mail: wangyr9t@xjtu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  National Natural Science Foundation of China No. 81471648, 81671661, 81771813
Received  2018-12-04
Accepted  2019-03-17
DOI: 10.12015/issn.1674-8034.2019.05.003
Cite this article as: Hu F, Wang L, Shi H, et al. The differences of DRD2TaqIA genotype on functional connectivity of insula in heroin addicts undergoing methadone maintenance treatment: a resting-state fMRI study. Chin J Magn Reson Imaging, 2019, 10(5): 331-336. DOI:10.12015/issn.1674-8034.2019.05.003.

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