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• Clinical Article •
Impairments of cerebral cortex and subcortical nucleus in cerebral hepatolenticular degeneration: magnetic resonance imaging study
KANG Taishan  YANG Tianhe  LIN Jianzhong  CAI Congbo  ZHANG Jiaxing 

Cite this article as: Kang TS, Yang TH, Lin JZ, et al. Impairments of cerebral cortex and subcortical nucleus in cerebral hepatolenticular degeneration: magnetic resonance imaging study. Chin J Magn Reson Imaging, 2019, 10(5): 337-341. DOI:10.12015/issn.1674-8034.2019.05.004.


[Abstract] Objective: To explore the damages of brain gray matter in patients with cerebral hepatolenticular degeneration.Materials and Methods: Brain 3D T1 weighted images were obtained from 30 patients with untreated cerebral hepatolenticular degeneration. One-way ANOVA was used to analyze group difference. Cortical gray matter and deep nucli volumes were analyzed using FMRIB Software Library (FSL) software and voxel based morphometry (VBM). Thirty healthy volunteers were enrolled as controls.Results: Compared with controls, the percentages of each cortical lobe atrophy and the comparison of bilateral cortical lobes were as follows: cerebellum (left 16.48%<right 16.54%, P>0.05), frontal cortex (left 23.6%>right 19.5%, P<0.001), temporal cortex (left 16.9%<right 25.4%, P<0.001), parietal cortex (left 15.5%<right 16.1%, P<0.001), occipital cortex (left 21.0%<right 27.2%, P<0.001), and insular cortex (left 58.7%>right 49.2%, P<0.001). The volumes of the brainstem and deep gray matter nuclei except the amygdale were significant atrophy. Atrophy percentage arranged in descending order was the accumbens nuclei, putamen nuclei, globus pallidus, thalamus, caudate nuclus, and brain-stem. There were no significant difference in the percentage of atrophy in each nucleus between the hemispheres.Conclusions: Cerebral hepatolenticular degeneration was characterized by bilaterally non-symmetrical cortical atrophy and symmetrical deep gray matter atrophy.
[Keywords] hepatolenticular degeneration；brain；magnetic resonance imaging

KANG Taishan Department of MRI, Zhongshan Affiliated Hospital of Xiamen University, Xiamen 361004, China

YANG Tianhe* Department of MRI, Zhongshan Affiliated Hospital of Xiamen University, Xiamen 361004, China

LIN Jianzhong Department of MRI, Zhongshan Affiliated Hospital of Xiamen University, Xiamen 361004, China

CAI Congbo College of information science and technology, Xiamen University, Xiamen 361005, China

ZHANG Jiaxing Institute of Brain Diseases and Cognition, Medical College of Xiamen University, Xiamen 361102, China

*Correspondence to: Yang TH, E-mail: yth13606916211@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This research was funded by National Natural Science Foundation of China No. 81671674, 81871519
Received  2018-12-27
Accepted  2019-03-20
DOI: 10.12015/issn.1674-8034.2019.05.004
Cite this article as: Kang TS, Yang TH, Lin JZ, et al. Impairments of cerebral cortex and subcortical nucleus in cerebral hepatolenticular degeneration: magnetic resonance imaging study. Chin J Magn Reson Imaging, 2019, 10(5): 337-341. DOI:10.12015/issn.1674-8034.2019.05.004.

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