Share：
Share this content in WeChat
X
[Chinese][PDF]117381
• Review •
The basic principle of ASL technology and its research progress in vascular cognitive impairment
JIANG Peiling  LUO Tianyou 

Cite this article as: Jiang PL, Luo TY. The basic principle of ASL technology and its research progress in vascular cognitive impairment. Chin J Magn Reson Imaging, 2019, 10(5): 393-396. DOI:10.12015/issn.1674-8034.2019.05.016.


[Abstract] Vascular cognitive impairment (VCI) is a group of syndromes ranging from mild cognitive impairment to dementia. As a functional magnetic resonance imaging (fMRI) technique, arterial spin labeling (ASL) can mark the cerebral blood of VCI patients at various stages without relying on the blood-brain barrier by marking the hydrogen protons in arterial blood with specific pulses. Flow rate with good time resolution has become an important imaging tool for diagnosis and follow-up of VCI. This paper reviews the basic principles of ASL technology and the research progress in VCI in recent years.
[Keywords] cognitive dysfunction；dementia, vascular；regional blood flow；brain；magnetic resonance imaging

JIANG Peiling Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China

LUO Tianyou* Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China

*Corresponding to: Luo TY, E-mall: ltychy@sina.com

Conflicts of interest   None.

Received  2018-11-01
Accepted  2019-01-22
DOI: 10.12015/issn.1674-8034.2019.05.016
Cite this article as: Jiang PL, Luo TY. The basic principle of ASL technology and its research progress in vascular cognitive impairment. Chin J Magn Reson Imaging, 2019, 10(5): 393-396. DOI:10.12015/issn.1674-8034.2019.05.016.

[1]
Rincon F, Wright CB. Vascular cognitive impairment. Curr Opin Neurol, 2013, 26(1): 29-36.
[2]
Bouvy WH, Zwanenburg JJ, Reinink R, et al. Perivascular spaces on 7 Tesla brain MRI are related to markers of small vessel disease but not to age or cardiovascular risk factors. J Cereb Blood Flow Metab, 2016, 36(10): 1708-1717.
[3]
Malojcic B, Giannakopoulos P, Sorond F A, et al. Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease. BMC Med, 2017, 15(1): 1-27.
[4]
Liu H, Zhang J. Cerebral hypoperfusion and cognitive impairment: the pathogenic role of vascular oxidative stress. Int J Neurosci, 2012, 122(9): 494-499.
[5]
Wang YH, An Y, Fan XT, et al. Comparison between simultaneously acquired arterial spin labeling and (18)F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG. Neuroimage Clin, 2018, 19(6): 824-830.
[6]
Rockwood K, Black SE, Song X, et al. Clinical and radiographic subtypes of vascular cognitive impairment in a clinic-based cohort study. J Neural Sci, 2006, 240(1-2): 7-14.
[7]
Cao X, Guo Q, Zhao Q, et al. The neuropsychological characteristics and regional cerebral blood flow of vascular cognitive impairment-no dementia. Int J Geriatr Psychiatry, 2010, 25(11): 1168-1176.
[8]
Hooghiemstra AM, Bertens AS, Leeuwis AE, et al. The missing link in the pathophysiology of vascular cognitive impairment: design of the heart-brain study. Cerebrovasc Dis Extra, 2017, 7(3): 140-152.
[9]
Patel B, Lawrence AJ, Chung AW, et al. Cerebral microbleeds and cognition in patients with symptomatic small vessel disease. Stroke, 2013, 44(2): 356-361.
[10]
Wallin A, Kapaki E, Boban M, et al. Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease: a consensus report. BMC Neurol, 2017, 17(1): 877-883.
[11]
Dolui S, Vidorreta M, Wang Z, et al. Comparison of PASL, PCASL, and background-suppressed 3D PCASL in mild cognitive impairment. Hum Brain Mapp, 2017, 38(10): 5260-5273.
[12]
Röhrich R, Hoekmeijer C, Osorio CI, et al. Quantifying single plasmonic nanostructure far-fields with interferometric and polarimetric k-space microscopy. Light Sci Appl, 2018, 12(9): 59-77.
[13]
Takahara K, Morioka T, Shimogawa T, et al. Hemodynamic state of periictal hyperperfusion revealed by arterial spin-labeling perfusion MR images with dual postlabeling delay. eNeurologicalSci, 2018, 12(9): 5-18.
[14]
胡英，陈莉，肖艳, 等. 正常人3D-ASL脑血流灌注最佳标记后延迟时间分析. 中国医学影像技术, 2016, 32(9): 1330-1335.
[15]
Kaneta T, Katsuse O, Hirano T, et al. Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer's disease: a cross-sectional study. BMC Neurol, 2017, 17(1): 870-883.
[16]
Takahashi H, Ishii K, Hosokawa C, et al. Clinical application of 3D arterial spin-labeled brain perfusion imaging for Alzheimer disease: comparison with brain perfusion SPECT. AJNR Am J Neuroradiol, 2014, 35(5): 906-911.
[17]
Nedelska Z, Senjem ML, Przybelski SA, et al. Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: associations with clinical severity, glucose metabolism and tau PET. Neuroimage Clin, 2018, 19(6): 939-947.
[18]
Sun Y, Cao W, Ding W, et al. Cerebral blood flow alterations as assessed by 3D ASL in cognitive impairment in patients with subcortical vascular cognitive impairment: a marker for disease severity. Front Aging Neurosci, 2016, 8(31): 211-220.
[19]
Knopman DS, Gottesman RF, Sharrett AR, et al. Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: the atherosclerosis risk in communities Study. Alzheimers Dement, 2018, 14(11): 1406-1415.
[20]
Zhu J, Wang Y, Li J, et al. Intracranial artery stenosis and progression from mild cognitive impairment to Alzheimer disease. Neurology, 2014, 82(10): 842-849.
[21]
Kapasi A, Schneider JA. Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons. Biochim Biophys, 2016, 1862(5): 878-886.
[22]
Dai W, Lopez OL, Carmichael OT, et al. Mild cognitive impairment and alzheimer disease: patterns of altered cerebral blood flow at MR imaging. Radiology, 2009, 250(3): 856-866.
[23]
Alexopoulos P, Sorg C, Förschler A, et al. Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI. Eur Arch Psychiatry Clin Neurosci, 2012, 262(1): 69-77.
[24]
Xekardaki A, Rodriguez C, Montandon ML, et al. Arterial spin labeling may contribute to the prediction of cognitive deterioration in healthy elderly individuals. Radiology, 2015, 274(2): 490-499.
[25]
Birdsill AC, Carlsson CM, Willette AA, et al. Low cerebral blood flow is associated with lower memory function in metabolic syndrome. Obesity, 2013, 21(7): 1313-1320.
[26]
Henderson TA. The diagnosis and evaluation of dementia and mild cognitive impairment with emphasis on SPECT perfusion neuroimaging. Cns Spectrums, 2012, 17(4): 176-206.
[27]
Austin BP, Nair VA, Meier TB, et al. Effects of hypoperfusion in Alzheimer's disease. J Alzheimers Dis, 2011, 26(3): 123-133.
[28]
Galvan V, Hart MJ. Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease. Biochim Biophys Acta, 2016, 1862(5): 992-1007.
[29]
Ding B, Ling HW, Zhang Y, et al. Pattern of cerebral hyperperfusion in Alzheimer's disease and amnestic mild cognitive impairment using voxel-based analysis of 3D arterial spin-labeling imaging: initial experience. Clin Interv Aging, 2014, 9(3): 493-500.
[30]
Sierramarcos A. Regional cerebral blood flow in mild cognitive impairment and Alzheimer's disease measured with arterial spin labeling magnetic resonance imaging. Int J Alzheimers Dis, 2017, 3(1): 547-597.
[31]
Thong JY, Du J, Ratnarajah N, et al. Abnormalities of cortical thickness, subcortical shapes, and white matter integrity in subcortical vascular cognitive impairment. Hum Brain Mapp, 2013, 35(5): 2320-2332.
[32]
Banerjee G, Wilson D, Jäger HR, et al. Novel imaging techniques in cerebral small vessel diseases and vascular cognitive impairment. Biochim Biophys Acta, 2016, 1862(5): 926-938.
[33]
Van Osch MJ, Teeuwisse WM, Chen Z, et al. Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow. J Cereb Blood Flow Metab, 2018, 38(9): 1461-1480.

PREV The states in multimodality MRI of methamphetamine induced psychosis and potential neural underpinnings
NEXT Application of amplitude of low-frequency fluctuation in ocular disease
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn