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• Clinical Article •
The application of mono-exponential model, bi-exponential model and stretched-exponential model DWI for preoperative grading of gliomas
HAO Fengling  WU Hui  NIU Guangming 

Cite this article as: Hao FL, Wu H, Niu GM. The application of mono-exponential model, bi-exponential model and stretched-exponential model DWI for preoperative grading of gliomas. Chin J Magn Reson Imaging, 2019, 10(6): 401-405. DOI:10.12015/issn.1674-8034.2019.06.001.


[Abstract] Objective: To explore the diagnostic performance of mono-exponential model, bi-exponential model and stretched-exponential model DWI for preoperative grading of gliomas, and evaluate the correlation between perfusion parameters and cerebral blood flow (CBF).Materials and Methods: Thirty-four patients with pathological confirmed glioma including 17 low-grade glioma patients and 17 high-grade glioma patients. Before operation, the subjects underwent coventionional MRI, three demensional arterial spin labeling (3D ASL) and multi-b value DWI; by using the mono-exponential model of FUNCTION TOOL software the apparent diffusion coefficient (ADC) was calculated; using bi-exponential model the fast ADC (D*), fraction of perfusion (f) and slow ADC (D) were calculated, using the stretched-exponential model the distribute diffusion coefficient (DDC) and alpha (α) were calculated, the CBF was obtained by 3D ASL software. The values obtained by FUNCTION TOOL software were analyzed by SAS9.4 statistical software.Results: The mean ADC, D, f, DDC, and ɑ values in high-grade glioma were lower than low-grade glioma, and the D* value was higher in high-grade glioma, P<0.05; there was positive correlation between D* and CBF of all the subjects (r=0.51, P<0.05); the receiver operating charactsteristic curve (ROC) analysis showed that the area under curve (AUC) of α , D, DDC and ADC values were 0.969, 0.965, 0.961, 0.957 respectively, and the diagnostic thresholds of ɑ, D, DDC, and ADC were 0.88×10-3 mm2/s, 0.86×10-3 mm2/s, 1.10×10-3 mm2/s, and 1.11×10-3 mm2/s, respectively.Conclusions: Mono-exponential model,bi-exponential model and stretched-exponential model DWI can provide more diagnostic information of glioma before surgery, and ɑ, D, DDC, ADC values are of high value in identifying high- and low-grade gliomas. The perfusion parameter D* was positively correlated with CBF.
[Keywords] mono-exponential model；bi-exponential model；stretched-exponential model；glioma；magnetic resonance imaging

HAO Fengling Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010000, China

WU Hui Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010000, China

NIU Guangming* Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010000, China

*Correspondence to: Niu GM, E-mail: cjr.niuguangming@vip.163.com

Conflicts of interest   None.

Received  2018-12-10
Accepted  2019-02-18
DOI: 10.12015/issn.1674-8034.2019.06.001
Cite this article as: Hao FL, Wu H, Niu GM. The application of mono-exponential model, bi-exponential model and stretched-exponential model DWI for preoperative grading of gliomas. Chin J Magn Reson Imaging, 2019, 10(6): 401-405. DOI:10.12015/issn.1674-8034.2019.06.001.

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