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• Clinical Article •
MRI study on brain structural changes induced by methamphetamine
SHEN Yunxia  LOU Mingwu  LIANG Wenbin  LU Lin  GONG Mingqiang 

Cite this article as: Shen YX, Lou MW, Liang WB, et al. MRI study on brain structural changes induced by methamphetamine. Chin J Magn Reson Imaging, 2019, 10(6): 406-409. DOI:10.12015/issn.1674-8034.2019.06.002.


[Abstract] Objective: To investigate brain structure changes induced by methamphetamine (MA) using AccuBrain software.Materials and Methods: Twenty-five methamphetamine addicts and thirty-seven healthy volunteers participated in this study. MRI examinations were performed using a 3.0 T Magnetom Prisma scanner (syngo MR D13D) with a sixty-four channel head/neck tim coil for signal reception. The data were processed with AccuBrain (Shenzhen BrainNow Medical Technology Ltd.). Brain structures were segmented automatically based on prior anatomical knowledge specified by experienced radiologists. The statistical task was achieved with SPSS 22.0. P<0.05 was considered significant.Results: The results revealed that there were significant differences between normal and MA group on relative volumes of cerebellum, left hippocampus, left inferior lateral ventricle and bilateral accumbens areas (P=0.011, 0.016,<0.001, 0.026 and 0.032, respectively). In details, there was smaller cerebellum, left hippocampus and bilateral accumbens areas, and larger left inferior lateral ventricle in MA group.Conclusions: These findings demonstrate that brain structure alters in methamphetamine addicts. Treatment and prevention can be targeted.
[Keywords] methamphetamine；magnetic resonance imaging；brain structure；addiction

SHEN Yunxia Department of Radiology, Longgang Central Hospital of ShenZhen, ShenZhen 518116, China

LOU Mingwu* Department of Radiology, Longgang Central Hospital of ShenZhen, ShenZhen 518116, China

LIANG Wenbin Department of Radiology, Longgang Central Hospital of ShenZhen, ShenZhen 518116, China

LU Lin Department of Radiology, Longgang Central Hospital of ShenZhen, ShenZhen 518116, China

GONG Mingqiang Department of Radiology, Longgang Central Hospital of ShenZhen, ShenZhen 518116, China

*Correspondence to: Lou MW, E-mail: mingwulou@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No.81471661 Department of Science and Technology of Longgang District Found No.20160607145932628, 20160606163814950
Received  2019-01-25
Accepted  2019-03-07
DOI: 10.12015/issn.1674-8034.2019.06.002
Cite this article as: Shen YX, Lou MW, Liang WB, et al. MRI study on brain structural changes induced by methamphetamine. Chin J Magn Reson Imaging, 2019, 10(6): 406-409. DOI:10.12015/issn.1674-8034.2019.06.002.

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