Share：
Share this content in WeChat
X
[Chinese][PDF]1015199
• Clinical Article •
MRI study on brain structural changes induced by methamphetamine
SHEN Yunxia  LOU Mingwu  LIANG Wenbin  LU Lin  GONG Mingqiang 

Cite this article as: Shen YX, Lou MW, Liang WB, et al. MRI study on brain structural changes induced by methamphetamine. Chin J Magn Reson Imaging, 2019, 10(6): 406-409. DOI:10.12015/issn.1674-8034.2019.06.002.


[Abstract] Objective: To investigate brain structure changes induced by methamphetamine (MA) using AccuBrain software.Materials and Methods: Twenty-five methamphetamine addicts and thirty-seven healthy volunteers participated in this study. MRI examinations were performed using a 3.0 T Magnetom Prisma scanner (syngo MR D13D) with a sixty-four channel head/neck tim coil for signal reception. The data were processed with AccuBrain (Shenzhen BrainNow Medical Technology Ltd.). Brain structures were segmented automatically based on prior anatomical knowledge specified by experienced radiologists. The statistical task was achieved with SPSS 22.0. P<0.05 was considered significant.Results: The results revealed that there were significant differences between normal and MA group on relative volumes of cerebellum, left hippocampus, left inferior lateral ventricle and bilateral accumbens areas (P=0.011, 0.016,<0.001, 0.026 and 0.032, respectively). In details, there was smaller cerebellum, left hippocampus and bilateral accumbens areas, and larger left inferior lateral ventricle in MA group.Conclusions: These findings demonstrate that brain structure alters in methamphetamine addicts. Treatment and prevention can be targeted.
[Keywords] methamphetamine；magnetic resonance imaging；brain structure；addiction

SHEN Yunxia Department of Radiology, Longgang Central Hospital of ShenZhen, ShenZhen 518116, China

LOU Mingwu* Department of Radiology, Longgang Central Hospital of ShenZhen, ShenZhen 518116, China

LIANG Wenbin Department of Radiology, Longgang Central Hospital of ShenZhen, ShenZhen 518116, China

LU Lin Department of Radiology, Longgang Central Hospital of ShenZhen, ShenZhen 518116, China

GONG Mingqiang Department of Radiology, Longgang Central Hospital of ShenZhen, ShenZhen 518116, China

*Correspondence to: Lou MW, E-mail: mingwulou@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No.81471661 Department of Science and Technology of Longgang District Found No.20160607145932628, 20160606163814950
Received  2019-01-25
Accepted  2019-03-07
DOI: 10.12015/issn.1674-8034.2019.06.002
Cite this article as: Shen YX, Lou MW, Liang WB, et al. MRI study on brain structural changes induced by methamphetamine. Chin J Magn Reson Imaging, 2019, 10(6): 406-409. DOI:10.12015/issn.1674-8034.2019.06.002.

[1]
Zhai TY, Shao YC, Chen G, et al. Nature of functional links in valuation networks differentiates impulsive behaviors between abstinent heroin-dependent subjects and nondrug-using subjects. Neuroimagie, 2015, 115: 76-84.
[2]
Pandria N, Kovatsi L, Vivas AB, et al. Resting-state abnornalities in heroin dependent individuals. Neuroscience, 2018, 378: 113-145.
[3]
Yadav SK, Kathiresan N, Mohan S, et al. Gender-based analysis of cortical thickness and structural connectivity in Parkinson's disease. J Neurol, 2016, 263(11): 2308-2318.
[4]
Taheri S, Xun Z, See RE, et al. Cocaine and methamphetamine induce opposing hanges in BOLD signal response in rats. Brain Research, 2016, 1642: 497-504.
[5]
国家禁毒办. 2017中国禁毒报告. 2017-03-23.
[6]
Kiyatkin EA, Sharma HS. Not just the brain: methamphetamine disrupts blood-spinal cord barrier and induces acute glial activation and structural damage of spinal cord cells. CNS Neurol Disord Drug Targets, 2015, 14(2): 282-294.
[7]
蒋富贵，郭辉，王宗岭, 等.长期吸食冰毒对神经内分泌的影响.中国药物滥用防治杂志, 2017, 23(3): 154-157.
[8]
Moeller S, Huttner HB, Struffert T, et al. Irreversible brain damage caused by methamphetamine persisting structural brain lesions. Alcoholism and Drug Addiction, 2016, 29(1): 39-41.
[9]
Thompson PM, Hayashi KM, Simon SL, et al. Structural abnormalities in the brains of human subjects who use methamphetamine. J Neurol, 2004, 24(26): 6028-6036.
[10]
Ruan X, Zhong N, Yang Z, et al. Gray matter volume showed dynamic alterations in methamphetamine users at 6 and 12 months abstinence:a longitudinal voxel-based morphometry study. Pro Neuropsychopharmacol Biol Psychiatry, 2018, 81(1): 350-355.
[11]
Roos A, Jones G, Howells FM, et al. Structural brain changes in prenatal methamphetamine-exposed children. Metabolic Brain Disease, 2014, 29(2): 341-349.
[12]
陈小莹，马靓，孙本良, 等. 冰毒成瘾对工作记忆的影响. 中国临床心理学杂志, 2018, 26(3): 427-431.

PREV The application of mono-exponential model, bi-exponential model and stretched-exponential model DWI for preoperative grading of gliomas
NEXT The correlation analysis between basilar artery bending angles and its plaque formation
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn