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• Clinical Article •
Correlation of mammography, MRI features and molecular typing of breast cancer
WANG Tingting  ZHOU Juan  TIAN Ning  YIN Hui  ZHAO Jianxiu  SHENG Fugeng 

Cite this article as: Wang TT, Zhou J, Tian N, et al. Correlation of mammography, MRI features and molecular typing of breast cancer. Chin J Magn Reson Imaging, 2019, 10(6): 420-424. DOI:10.12015/issn.1674-8034.2019.06.005.


[Abstract] Objective: To analyze the mammography and MRI features of breast cancer, and to explore the relationship between them and molecular subtypes.Materials and Methods: We retrospectively analyzed the mammography and MRI findings of 175 patients with breast cancer. According to the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2) and Ki-67 determined the molecular subtypes of breast cancer and analyzed the relationship between imaging features and molecular subtypes.Results: Most of Luminal B and HER-2 positive breast cancer had lymph nodes metastasis, less Luminal A and triple negative breast cancer had node metastasis (P<0.05). Suspicious calcification was more common in HER-2 overexpression breast cancer than in other subtypes (P<0.05). Most of the triple negative breast cancer showed rim enhancement, while other subtypes showed heterogeneous enhancement (P<0.05).Conclusions: The phenotypes of mammography and MRI are diverse in different subtypes of breast cancer, and some features are related to the molecular subtypes. The combination of mammography and MRI can be used to distinguish the molecular subtypes of breast cancer and provide reference for clinical diagnosis and individualized treatment.
[Keywords] breast neoplasms；mammography；magnetic resonance imaging；molecular typing

WANG Tingting PLA 307 Clinical College, Anhui Medical University, Hefei 230032, China; The Fifth Medical Center of PLA General Hospital, Beijing 100071, China

ZHOU Juan The Fifth Medical Center of PLA General Hospital, Beijing 100071, China

TIAN Ning The Fifth Medical Center of PLA General Hospital, Beijing 100071, China

YIN Hui PLA 307 Clinical College, Anhui Medical University, Hefei 230032, China; The Fifth Medical Center of PLA General Hospital, Beijing 100071, China

ZHAO Jianxiu The Fifth Medical Center of PLA General Hospital, Beijing 100071, China

SHENG Fugeng* PLA 307 Clinical College, Anhui Medical University, Hefei 230032, China; The Fifth Medical Center of PLA General Hospital, Beijing 100071, China

*Correspondence to: Sheng FG, E-mail: fugeng_sheng@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No.21575161
Received  2019-01-13
Accepted  2019-04-30
DOI: 10.12015/issn.1674-8034.2019.06.005
Cite this article as: Wang TT, Zhou J, Tian N, et al. Correlation of mammography, MRI features and molecular typing of breast cancer. Chin J Magn Reson Imaging, 2019, 10(6): 420-424. DOI:10.12015/issn.1674-8034.2019.06.005.

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