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Research progress of MRI neuroimaging in HIV-associated neurocognitive disorders
LI Ruili  LI Hongjun 

Cite this article as: Li RL, Li HJ. Research progress of MRI neuroimaging in HIV-associated neurocognitive disorders. Chin J Magn Reson Imaging, 2019, 10(6): 456-460. DOI:10.12015/issn.1674-8034.2019.06.013.


[Abstract] HIV can enter the central nervous system (CNS) soon after seroconversion (8 days) due to its neurotropic and cause persistent CNS damage. With ongoing injury to the brain, 50% of the infected individuals will progress to cognitive, behavioral and motor abnormalities, which are called HIV-associated neurocognitive disorders (HAND). While the more severe and progressive forms of HAND (HAD) are less prevalent due to cART, about 40% of HIV- infected patients continue to have two mild forms of HAND (ANI and MND). Cognitive impairment gradually worsens with the extension of the survival period. Diagnosis of HAND is mainly based upon an individual’s performance on multiple cognitive domains, which is time-consuming (3 hours). MRI is non-invasive and radiationless. Different neuroimaging sequences [diffusion tensor imaging (DTI), 3D T1WI, function MRI)] can be used to obtain the required information from different perspectives, to offer unique insight into early diagnosis and mechanisms underlying neuro HIV, to monitor disease progression, and to assist in evaluating the efficacy of particular cART regimens. We reviewed the progress of MRI neuroimaging in HAND.
[Keywords] acquired immunodeficiency syndrome；cognitive dysfunction；magnetic resonance imaging；brain structure；brain function

LI Ruili Department of Radiology, Beijing Youan Hospital, Capital Medical Universtiy, Beijing 100069, China

LI Hongjun* Department of Radiology, Beijing Youan Hospital, Capital Medical Universtiy, Beijing 100069, China

*Corresponding to: Li HJ, E-mail: lihongjun00113@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Natural Science Foundation of China No. 81771806 Capital Medical University Research and Incubation Funding No. PYZ2017124 Beijing Municipal Administration of Hospitals Incubating Program No. PX2016036
Received  2018-12-26
Accepted  2019-01-30
DOI: 10.12015/issn.1674-8034.2019.06.013
Cite this article as: Li RL, Li HJ. Research progress of MRI neuroimaging in HIV-associated neurocognitive disorders. Chin J Magn Reson Imaging, 2019, 10(6): 456-460. DOI:10.12015/issn.1674-8034.2019.06.013.

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