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• Clinical Article •
Application value of diffusion kurtosis imaging in diagnosis of early Parkinson's disease
LI Yan  SI Haina  TIAN Yuling  WANG Xiaochun 

Cite this article as: Li Y, Si HN, Tian YL, et al. Application value of diffusion kurtosis imaging in diagnosis of early Parkinson's disease. Chin J Magn Reson Imaging, 2019, 10(7): 486-490. DOI:10.12015/issn.1674-8034.2019.07.002.


[Abstract] Objective: To investigate the value of magnetic resonance diffusion kurtosis imaging (DKI) in the diagnosis of early Parkinson's disease (PD).Materials and Methods: From September 2017 to September 2018, 21 patients with primary early PD diagnosed by PD Department of First Hospital of Shanxi Medical University (Hoeh-Yahr grade 1—2.5) were selected. In the same period, 20 healthy volunteers with matched age and gender were also enrolled as the healthy control (HC). All subjects underwent brain routine magnetic resonance imaging (MRI) and DKI. After the DKI raw data were processed, fractional anisotropy (FA), a mean diffusivity (MD), and a mean kurtosis (MK) maps were obtained. The DKI parameters of bilateral substantia nigra (SN), caudate nucleus (CN), globus pallidus (GP), putamen (PU), and thalamus (TH) were measured and the statistical differences between the two groups were compared. The correlation between the parameters of the early PD patients and the disease course and clinical scores were analyzed. The diagnostic efficiency of statistically significant parameter values for early PD patients was evaluated by receiver operating characteristic (ROC) curves.Results: Compared with 20 healthy volunteers, the FA values of the bilateral caudate nucleus, globus pallidus, putamens and thalamus were significantly lower in early PD patients (P<0.05); the MK values of bilateral substantia nigra were significantly increased (P<0.05). The MK value of the right substantia nigra in the PD group was negatively correlated with the Hoeh-Yahr grade (P<0.05, t=0.076).Conclusions: DKI has certain application value in detecting the pathological changes of gray matter nucleus in the brain of early PD patients, and the FA values of the bilateral putamen are more sensitive to the diagnosis of early PD patients, and the MK values of bilateral substantia nigra have more specificity.
[Keywords] parkinson disease；magnetic resonance imaging；diffusion kurtosis imaging

LI Yan Department of Medical Imaging, Shanxi Medical University, Taiyuan 030000, China

SI Haina The First Clinical Medical College of Shanxi Medical University, Taiyuan 030000, China

TIAN Yuling Department of Neurology, the First Hospital of Shanxi Medical University, Taiyuan 030000, China

WANG Xiaochun* Department of Radiology, the First Hospital of Shanxi Medical University, Taiyuan 030000, China

*Correspondence to: Wang XC, E-mail: 2010xiaochun@163.com

Conflicts of interest   None.

Received  2018-12-13
Accepted  2019-03-20
DOI: 10.12015/issn.1674-8034.2019.07.002
Cite this article as: Li Y, Si HN, Tian YL, et al. Application value of diffusion kurtosis imaging in diagnosis of early Parkinson's disease. Chin J Magn Reson Imaging, 2019, 10(7): 486-490. DOI:10.12015/issn.1674-8034.2019.07.002.

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