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• Clinical Article •
Assessment of myelination progression in subcortical white matter of infant with periventricular leukomalacia using T2-weighted imaging based visual scoring method
LIU Congcong  HUANG Tingting  WANG Miaomiao  ZHAO Huifang  LIU Heng  LI Xianjun  JIN Chao  SUN Qinli  YANG Jian 

Cite this article as: Liu CC, Huang TT, Wang MM, et al. Assessment of myelination progression in subcortical white matter of infant with periventricular leukomalacia using T2-weighted imaging based visual scoring method. Chin J Magn Reson Imaging, 2019, 10(7): 497-503. DOI:10.12015/issn.1674-8034.2019.07.004.


[Abstract] Objective: The purpose of this study was to assess the subcortical white matter (WM) myelination progress via T2-weighted imaging (T2WI) based visual scoring method in the infant of periventricular leukomalacia (PVL) during age of 6—20 months and validate the applicability of this scoring method in screening abnormal WM myelination progress in infant with PVL.Materials and Methods: We retrospectively recruited infant with diagnosis of PVL, and infant without abnormalities on MRI during age of 6-20 months from November 2010 to June 2017. Infant with PVL were divided into three groups: mild, moderate and severe. Subcortical WM myelination progress of infant in control group, PVL groups was assessed via the T2WI-based visual scoring method. Then myelination scores of regional and whole brain were compared between different PVL groups and control group using Mann-Whitney U test. Then linear regression and Spearman correlations were applied to assess the association between myelination score and age in the control and PVL groups.Results: In this study, the significant difference in subcortical WM myeliantion score of parietal lobe was found between mild PVL group and control group (P=0.033); and except temproal lobe, other brain lobes were observed differences in subcortical WM myeliantion score between moderate, severe PVL groups and control group. The positive linear correlations between age and the myeliantion score were found in both PVL groups and control group (P<0.05). And the correlation coefficients of control group were higher than PVL groups.Conclusions: The T2WI-based visual scoring method was useful and applicable in screening myelination progress of the moderate and severe PVL in infant aged 6—20 months in clinic.
[Keywords] infant；leukomalacia, periventricular；magnetic resonance imaging

LIU Congcong Department of Radiology, the First Affliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

HUANG Tingting Department of Radiology, the First Affliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China; Department of Radiology, the First Affliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China

WANG Miaomiao Department of Radiology, the First Affliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

ZHAO Huifang Department of Radiology, the First Affliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

LIU Heng Department of Radiology, the First Affliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

LI Xianjun Department of Radiology, the First Affliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

JIN Chao Department of Radiology, the First Affliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

SUN Qinli Department of Radiology, the First Affliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

YANG Jian* Department of Radiology, the First Affliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

*Correspondence to: Yang J, E-mail: cjr.yangjian@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work was part of National Key Research and Development Program of China No. 2016YFC0100300 National Natural Science Foundation of China No. 81471631, 81771810 and 51706178 2011 New Century Excellent Talent Support Plan of the Ministry of Education, China No. NCET-11-0438 Shaanxi Provincial Natural Science Foundation for Youths of China No. 2017JQ8005 Clinical Research Award of the First Affliated Hospital of Xi’an Jiaotong University No. XJTU1AF-CRF-2015-004
Received  2019-01-09
Accepted  2019-05-25
DOI: 10.12015/issn.1674-8034.2019.07.004
Cite this article as: Liu CC, Huang TT, Wang MM, et al. Assessment of myelination progression in subcortical white matter of infant with periventricular leukomalacia using T2-weighted imaging based visual scoring method. Chin J Magn Reson Imaging, 2019, 10(7): 497-503. DOI:10.12015/issn.1674-8034.2019.07.004.

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