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• Clinical Article •
Magnetic resonance imaging assessment of isocitrate dehydrogenase 1 mutation status in degenerative astrocytoma
KE Xiaoai  ZHANG Qiaoying  ZHOU Qing  HAN Lei  ZHANG Wenjuan  ZHOU Junlin 

Cite this article as: Ke XA, Zhang QY, Zhou Q, et al. Magnetic resonance imaging assessment of isocitrate dehydrogenase 1 mutation status in degenerative astrocytoma. Chin J Magn Reson Imaging, 2019, 10(7): 504-508. DOI:10.12015/issn.1674-8034.2019.07.005.


[Abstract] Objective: To analyze the MRI features of the isocitrate dehydrogenase 1 (IDH-1) mutant and the IDH-1 wild type of the anaplastic astrocytoma.Materials and Methods: Forty-five cases of anaplastic astrocytoma confirmed by surgery and pathology were selected, including 20 cases of IDH-1 mutation and 25 cases of IDH-1 wild type. All cases underwent conventional MRI sequence enhanced T1WI, T2WI, FLAIR, DWI and T1WI. The sex, age, location, number of lesions, tumor boundary, cystic degeneration and necrosis, hemorrhage, tumor maximum diameter, edema maximum diameter, enhancement degree, minimum apparent diffusion coefficient (mADC) value, ratio of mADC (rmADC) were statistically analyzed.Results: In the anaplastic astrocytoma, the IDH-1 mutant appeared in the right frontal lobe, and the IDH-1 wild type occurred in the left frontal lobe. There was a statistical difference between the two groups (P<0.05). The IDH-1 mutant had cystic necrosis accounted for 45%, and the wild type accounted for 75%. There was a statistically significant difference between the two groups (P<0.05). The degree of enhancement was non-enhanced, mildly enhanced, moderately enhanced, and severely enhanced. The IDH-1 mutants accounted for 25%, 50%, 20%, and 5%, respectively, and the IDH-1 wild type accounted for 8%, 12%, and 52%, respectively. 28%, there was a statistical difference between the two groups (P<0.05). The maximum diameter of the IDH-1 mutant tumor (50.01±19.11 mm) was smaller than that of the IDH-1 wild type (64.58±11.52 mm). The mean value of mADC in IDH-1 mutation group was (1.17±0.20)×10-3 mm2/s, the mean value of mADC in IDH-1 wild group was (0.84±0.14)×10-3 mm2/s; the mean value of rmADC in IDH-1 mutation group was (0.16±0.04)×10-3 mm2/s, the mean value of rmADC in IDH-1 wild group was (0.13±0.02)×10-3 mm2/s, and there was statistical difference between the two groups (P<0.05). There was no significant difference between the two groups in sex, age, number of lesions, tumor margin, presence or absence of hemorrhage or edema (P>0.05).Conclusions: The occurrence of anaplastic astrocytoma, the rate of cyst necrosis, the degree of enhancement, the maximum diameter of the tumor, the mADC value, and the rmADC value can be used to evaluate the IDH-1 mutation status of the anaplastic glioma before surgery, and then guide the clinical individualized treatment plan. And prognosis assessment.
[Keywords] astrocytoma；anaplasia；isocitrate dehydrogenase；magnetic resonance imaging

KE Xiaoai Radiology Imaging Center, Second Hospital of Lanzhou University, Lanzhou 730030, China

ZHANG Qiaoying Radiology Imaging Center, Second Hospital of Lanzhou University, Lanzhou 730030, China

ZHOU Qing Radiology Imaging Center, Second Hospital of Lanzhou University, Lanzhou 730030, China

HAN Lei Radiology Imaging Center, Second Hospital of Lanzhou University, Lanzhou 730030, China

ZHANG Wenjuan Radiology Imaging Center, Second Hospital of Lanzhou University, Lanzhou 730030, China

ZHOU Junlin* Radiology Imaging Center, Second Hospital of Lanzhou University, Lanzhou 730030, China

*Correspondence to: Zhou JL, E-mail: zjl601@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This paper is supported by the National Natural Science Foundation of China No. 81772006
Received  2018-10-04
Accepted  2019-03-20
DOI: 10.12015/issn.1674-8034.2019.07.005
Cite this article as: Ke XA, Zhang QY, Zhou Q, et al. Magnetic resonance imaging assessment of isocitrate dehydrogenase 1 mutation status in degenerative astrocytoma. Chin J Magn Reson Imaging, 2019, 10(7): 504-508. DOI:10.12015/issn.1674-8034.2019.07.005.

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