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• Clinical Article •
The diagnostic value of three-dimensional real inversion recovery MR imaging in the inner ear lymphography in patients with meniere's disease
CHEN Zhongliang  DENG Hong  ZENG Weike  YI Zhilong  SU Yun  YANG Zehong  XIE Mingwei 

Cite this article as: Chen ZL, Deng H, Zeng WK, et al. The diagnostic value of three-dimensional real inversion recovery MR imaging in the inner ear lymphography in patients with meniere's disease. Chin J Magn Reson Imaging, 2019, 10(7): 509-513. DOI:10.12015/issn.1674-8034.2019.07.006.


[Abstract] Objective: To compare the diagnostic value of three-dimensional fluid-attenuated inversion recovery (3D FLAIR) and 3D real inversion recovery (3D real IR) sequence after intratympanic injection of Gadolinium-diethylene triamine pentaacetic acids (Gd-DTPA) in the visualization of endolymphatic hydrops (EH) in patients with meniere's disease (MD).Materials and Methods: Twenty-nine patients with MD were included in this study. There were 10 men and 19 women, aged from 22 to 71. Twelve patients had MD in bilateral ears and 17 patients had MD in unilateral ear. A total of 41 ears were involved. The EH in the vestibule and cochlea of 41 sick ears of 29 MD patients was retrospectively quantitatively and qualitatively analyzed. The bilateral ears of all the patient were intratympanic injected with diluted Gd-DTPA. After 24 hours, both 3D FLAIR and 3D real IR sequence were performed. The ratio (R) of the area of the endolymphatic space to the sum of the endolymphatic and perilymphatic space was measured in these two sequences (RV in the vestibule and RC in the cochlea). And the grading (G) of EH was assessed (GV in the vestibule, GC in the cochlea). Corresponding statistical methods were used to compare the RV, RC, GV and GC acquired from the two sets of sequence images.Results: Among 41 ears in 29 patients, the RV, RC, GC and GV from the two sequences were statistically different (PRV=0.000, PRC=0.000, PGV=0.000, PGC=0.001). The RV and RC of the 3D real IR sequence were larger than those of the 3D FLAIR sequence, and the number of sick ears which’s GV and GC ranged 1—2 (ie, found EH) was greater than that of the 3D FLAIR sequence.Conclusions: Compared with the 3D FLAIR sequence, the 3D real IR sequence is more sensitive for the detection of EH in MD patients and has a higher detection rate.
[Keywords] Meniere's disease；inner ear；lymphography；magnetic resonance imaging

CHEN Zhongliang Department of Radiology, Chaozhou People's Hospital of Guangdong Province, Chaozhou 521000, China

DENG Hong Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

ZENG Weike Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

YI Zhilong Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

SU Yun Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

YANG Zehong Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

XIE Mingwei* Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

*Correspondence to: Xie MW, E-mail: xie_class@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This work is supported by the Project Supported by Guangdong Natural Science Foundation No. 2017A030313777
Received  2019-03-12
Accepted  2019-05-11
DOI: 10.12015/issn.1674-8034.2019.07.006
Cite this article as: Chen ZL, Deng H, Zeng WK, et al. The diagnostic value of three-dimensional real inversion recovery MR imaging in the inner ear lymphography in patients with meniere's disease. Chin J Magn Reson Imaging, 2019, 10(7): 509-513. DOI:10.12015/issn.1674-8034.2019.07.006.

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