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• Clinical Article •
Intravoxel incoherent motion diffusion weighted imaging and T1 mapping for the evaluation of autoimmune pancreatitis: a clinical study
CANG Lizhuo  ZHANG Xianyi  CAI Xiaoli  WANG Min  JI Ruoyun  SHI Yu 

Cite this article as: Cang LZ, Zhang XY, Cai XL, et al. Intravoxel incoherent motion diffusion weighted imaging and T1 mapping for the evaluation of autoimmune pancreatitis: a clinical study. Chin J Magn Reson Imaging, 2019, 10(7): 519-524. DOI:10.12015/issn.1674-8034.2019.07.008.


[Abstract] Objective: To evaluate the diagnostic performance of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) and T1 mapping for the evaluation of autoimmune pancreatitis (AIP).Materials and Methods: A total of 26 patients with AIP confirmed by pathology and clinical evaluation, 18 healthy volunteers and 39 patients with pancreatic cancer (PC) confirmed histologically underwent IVIM-DWI and T1 mapping with 9 different b values (0, 25, 75, 100, 150, 200, 500, 800 and 1000 s/mm2). The difference of T1 value and IVIM-DWI imaging parameters [true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f)] were analyzed between normal pancreas, PC and AIP groups. Receiver operating characteristic curve (ROC) analysis was performed to evaluate the diagnostic performance of the D, D* and f for differentiation between AIP and PC, and AIP and normal pancreas.Results: The mean f value in normal pancreas, PC and AIP was (20.6±4.2)%, (12.0±3.7)% and (9.1±3.1)%, respectively, with statistical difference among groups (P<0.001). The diagnostic performance of f value [area under the ROC curve (AUC) of 0.970 and 0.747, respectively] in differentiating normal pancreas from AIP, and AIP from PC was better than that of T1 value (AUC=0.949, 0.685), D (AUC: 0.513 and 0.582) and D* (AUC: 0.825 and 0.493).Conclusions: Perfusion fraction f by IVIM-DWI is a promising method in differential diagnosis of AIP.
[Keywords] pancreatitis；autoimmunity；magnetic resonance imaging

CANG Lizhuo Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China

ZHANG Xianyi Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China

CAI Xiaoli Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China

WANG Min Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China

JI Ruoyun Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China

SHI Yu* Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110004, China

*Correspondence to: Shi Y, E-mail: 18940259980@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS  This article is supported by the National Natural Science Foundation of China NO. 81771802, 81771893, 81471718 Liaoning Province Innovative Talent Support Program NO. LR2016020 Outstanding Youth Foundation of China Medical University NO. YQ20160005
Received  2019-01-13
Accepted  2019-04-20
DOI: 10.12015/issn.1674-8034.2019.07.008
Cite this article as: Cang LZ, Zhang XY, Cai XL, et al. Intravoxel incoherent motion diffusion weighted imaging and T1 mapping for the evaluation of autoimmune pancreatitis: a clinical study. Chin J Magn Reson Imaging, 2019, 10(7): 519-524. DOI:10.12015/issn.1674-8034.2019.07.008.

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